ubiquitin protein ligase E3 component n-recognin 2

 jump to detail

Synonym

bA49A4.1, Ubiquitin-protein ligase E3 component N-recognin-2, UBR2, Ubiquitin-protein ligase E3-alpha-2, RP3-392M17.3, DKFZp686C08114, MGC71112, ubiquitin protein ligase E3 component n-recognin 2, dJ242G1.1, C6orf133, chromosome 6 open reading frame 133, dJ392M17.3, Ubiquitin-protein ligase E3-alpha-II, KIAA0349

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:37.90 cerebellum:50.40 brain stem:- corpus callosum/glia:29.20 pineal gland:148.30 peripheral nerve:30.70 spine:112.30 retina:237.30 eye:64.60 artery/aorta:- vein:- lymphnode:70.80 peripheral blood:36.40 spleen:94.50 thymus:51.50 bone marrow:19.70 adipose:- bone:25.60 skin:72
GeneChip cerebrum:5.61 cerebellum:5.64 brain stem:5.72 corpus callosum/glia:6.11 pineal gland:- peripheral nerve:6.01 spine:5.64 retina:- eye:- artery/aorta:6.27 vein:6.29 lymphnode:6.51 peripheral blood:- spleen:6.55 thymus:6.57 bone marrow:6.76 adipose:6.35 bone:- skin:6.33
CAGE cerebrum:3.58 cerebellum:- brain stem:3.67 corpus callosum/glia:3.72 pineal gland:4.01 peripheral nerve:- spine:3.57 retina:- eye:- artery/aorta:3.71 vein:3.50 lymphnode:3.68 peripheral blood:- spleen:3.68 thymus:3.86 bone marrow:- adipose:3.81 bone:- skin:-
RNA-seq cerebrum:2.33 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.86 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:100.20 placenta:43.70 prostate:45.10 ovary:- testis:30.30 heart:25.50 muscle:40.20 esophagus:- stomach:127.50 intestine:- colon:67.80     liver/hepato:52.80        lung:92.90    bladder:- kidney:104 pituitary:232 thyroid/parathyroid:- adrenal gland:- pancreas:17.80 breast:9.30 salivary:-
GeneChip uterus:6.40 placenta:6.03 prostate:6.50 ovary:6.31 testis:5.81 heart:6.21 muscle:6.37 esophagus:6.42 stomach:6.29 intestine:6.32 colon:5.93 liver/hepato:6.29 lung:6.61 bladder:- kidney:5.80 pituitary:5.74 thyroid/parathyroid:6.26 adrenal gland:6.25 pancreas:6.23 breast:6.60 salivary:6.21
CAGE uterus:4.00 placenta:3.37 prostate:3.67 ovary:3.49 testis:3.31 heart:3.61 muscle:3.93 esophagus:3.61 stomach:- intestine:3.96 colon:3.71     liver/hepato:3.49    lung:3.88 bladder:3.70 kidney:3.49 pituitary:3.96 thyroid/parathyroid:3.56 adrenal gland:- pancreas:3.47 breast:3.43 salivary:3.85
RNA-seq uterus:- placenta:- prostate:3.33 ovary:3.06 testis:2.87 heart:3.06 muscle:3.61 esophagus:- stomach:- intestine:- colon:2.74     liver/hepato:2.32        lung:2.83    bladder:- kidney:3.28 pituitary:- thyroid/parathyroid:3.54 adrenal gland:2.97 pancreas:- breast:3.16 salivary:-

Gene Information

IDs

Refseq ID NM_015255
Gene ID 23304
Unigene ID Hs.529925
Probe set ID 212756_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000024048
GTEx ID ENSG00000024048

Orthologous Gene

Mouse[1]  NM_001177374, NM_146078
Rat [0]  

Chromosomal Region

6p21.1  [42,531,800  -  42,661,242]

Gene Family (Interpro ID)

IPR003126  Zinc finger, N-recognin
IPR013993  Zinc finger, N-recognin, metazoa

Link to Pubmed  (Pubmed ID)

9205841
12477932
14574404
14585983
14702039
15317757
15489334
15548684
16196087
16311597
17314511
17360488
17643375
17855541
18029348
18775313
19940298
20080676
20298436
20379614
21139048
21573678
21816346
21890473
21903422
21906983
21963094
21987572
22053931
22190034
22190037
22505724
22616001
23000965
23251661

Gene Ontology  (GO ID)

Biological Process

GO:0071233  cellular response to leucine
GO:0006342  chromatin silencing
GO:0033522  histone H2A ubiquitination
GO:0007141  male meiosis I
GO:0032007  negative regulation of TOR signaling pathway
GO:0007283  spermatogenesis
GO:0006511  ubiquitin-dependent protein catabolic process

Cellular Component

GO:0000785  chromatin
GO:0005730  nucleolus
GO:0005634  nucleus
GO:0005886  plasma membrane
GO:0000151  ubiquitin ligase complex

Molecular Function

GO:0070728  leucine binding
GO:0005515  protein binding
GO:0004842  ubiquitin-protein ligase activity
GO:0008270  zinc ion binding