ubiquitin specific peptidase 22

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Synonym

ubiquitin specific protease 22, ubiquitin specific peptidase 3-like, Ubiquitin-specific-processing protease 22, USP22, KIAA1063, Deubiquitinating enzyme 22, ubiquitin specific peptidase 22, USP3L, Ubiquitin carboxyl-terminal hydrolase 22, Ubiquitin thioesterase 22

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:246.50 cerebellum:327.40 brain stem:- corpus callosum/glia:87.50 pineal gland:148.30 peripheral nerve:184 spine:336.90 retina:237.30 eye:123.40 artery/aorta:- vein:- lymphnode:131.40 peripheral blood:18.20 spleen:75.60 thymus:77.30 bone marrow:59 adipose:- bone:153.50 skin:177.60
GeneChip cerebrum:8.77 cerebellum:8.76 brain stem:8.67 corpus callosum/glia:8.43 pineal gland:- peripheral nerve:8.76 spine:8.56 retina:- eye:- artery/aorta:8.43 vein:7.71 lymphnode:8.30 peripheral blood:- spleen:8.62 thymus:8.53 bone marrow:7.68 adipose:8.04 bone:- skin:8.37
CAGE cerebrum:5.16 cerebellum:- brain stem:4.92 corpus callosum/glia:5.03 pineal gland:5.13 peripheral nerve:- spine:4.65 retina:- eye:- artery/aorta:4.80 vein:4.77 lymphnode:4.67 peripheral blood:- spleen:4.49 thymus:5.08 bone marrow:- adipose:4.62 bone:- skin:-
RNA-seq cerebrum:5.68 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.87 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.93 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:91.10 placenta:80.10 prostate:202.80 ovary:74.50 testis:90.90 heart:166 muscle:40.20 esophagus:- stomach:127.50 intestine:64.80 colon:33.90     liver/hepato:84.40        lung:92.90    bladder:- kidney:52 pituitary:116 thyroid/parathyroid:163.70 adrenal gland:152.40 pancreas:35.60 breast:139.40 salivary:-
GeneChip uterus:8.64 placenta:7.78 prostate:8.85 ovary:8.74 testis:8.34 heart:8.22 muscle:8.42 esophagus:8.19 stomach:8.27 intestine:7.98 colon:7.94 liver/hepato:8.30 lung:8.01 bladder:- kidney:8.44 pituitary:8.91 thyroid/parathyroid:8.92 adrenal gland:8.82 pancreas:6.98 breast:8.64 salivary:7.82
CAGE uterus:4.80 placenta:4.61 prostate:4.63 ovary:4.82 testis:4.64 heart:4.84 muscle:5.04 esophagus:4.28 stomach:- intestine:4.32 colon:4.61     liver/hepato:4.55    lung:4.66 bladder:4.33 kidney:4.56 pituitary:4.79 thyroid/parathyroid:4.55 adrenal gland:- pancreas:4.48 breast:4.70 salivary:4.49
RNA-seq uterus:- placenta:- prostate:4.69 ovary:5.63 testis:4.66 heart:4.67 muscle:5.82 esophagus:- stomach:- intestine:- colon:4.38     liver/hepato:4.10        lung:4.61    bladder:- kidney:4.93 pituitary:- thyroid/parathyroid:5.54 adrenal gland:4.82 pancreas:- breast:4.80 salivary:-

Gene Information

IDs

Refseq ID NM_015276
Gene ID 23326
Unigene ID Hs.462492
Probe set ID 200083_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000124422
GTEx ID ENSG00000124422

Orthologous Gene

Mouse[1]  NM_001004143
Rat[1]  NM_001004143

Chromosomal Region

17p11.2  [20,902,906  -  20,947,073]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

10470851
11707075
12477932
12838346
15931389
16169070
16378762
18206972
18206973
18469533
18838386
19615732
19843541
20824490
21039844
21139048
21337558
21691749
21735131
21746879
21773699
21779003
21890473
21900206
21906983
21928107
21963094
21987572
22053931
22067483
22118674
22447106
22505724
22542455
22880026
23000965
23217440
23300749
23361242
23382074
23412977
23664741
23720494
23979981
24197134
24250222
24561192
24654937

Gene Ontology  (GO ID)

Biological Process

GO:0007049  cell cycle
GO:0009790  embryonic development
GO:0016578  histone deubiquitination
GO:0043967  histone H4 acetylation
GO:0016574  histone ubiquitination
GO:0045931  positive regulation of mitotic cell cycle
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0016579  protein deubiquitination
GO:0006351  transcription, DNA-dependent
GO:0006511  ubiquitin-dependent protein catabolic process

Cellular Component

GO:0000124  SAGA complex
GO:0070461  SAGA-type complex

Molecular Function

GO:0010485  H4 histone acetyltransferase activity
GO:0030374  ligand-dependent nuclear receptor transcription coactivator activity
GO:0005515  protein binding
GO:0003713  transcription coactivator activity
GO:0004221  ubiquitin thiolesterase activity
GO:0004843  ubiquitin-specific protease activity
GO:0008270  zinc ion binding