dicer 1, ribonuclease type III

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Synonym

Helicase with RNase motif, DICER, Endoribonuclease Dicer, DICER1, Helicase-MOI, HERNA, KIAA0928, Dicer, K12H4.8-LIKE, Dicer1, Dcr-1 homolog (Drosophila)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:94.80 cerebellum:37.80 brain stem:- corpus callosum/glia:29.20 pineal gland:296.70 peripheral nerve:30.70 spine:112.30 retina:118.60 eye:141 artery/aorta:- vein:133.30 lymphnode:121.30 peripheral blood:36.40 spleen:- thymus:90.20 bone marrow:39.40 adipose:- bone:38.40 skin:67.20
GeneChip cerebrum:6.96 cerebellum:6.91 brain stem:7.11 corpus callosum/glia:8.24 pineal gland:- peripheral nerve:6.99 spine:7.59 retina:- eye:- artery/aorta:5.98 vein:5.91 lymphnode:6.68 peripheral blood:- spleen:7.10 thymus:7.61 bone marrow:6.49 adipose:6.46 bone:- skin:6.31
CAGE cerebrum:3.85 cerebellum:- brain stem:4.13 corpus callosum/glia:4.31 pineal gland:3.86 peripheral nerve:- spine:4.17 retina:- eye:- artery/aorta:3.42 vein:3.32 lymphnode:3.56 peripheral blood:- spleen:3.86 thymus:3.51 bone marrow:- adipose:3.94 bone:- skin:-
RNA-seq cerebrum:2.58 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.21 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.23 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:54.70 placenta:61.90 prostate:56.30 ovary:149.10 testis:30.30 heart:102.20 muscle:40.20 esophagus:- stomach:- intestine:32.40 colon:42.40     liver/hepato:-        lung:73.30    bladder:251.20 kidney:52 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:151.10 breast:176.60 salivary:-
GeneChip uterus:7.22 placenta:8.01 prostate:7.38 ovary:7.34 testis:5.83 heart:6.66 muscle:7.17 esophagus:7.15 stomach:6.76 intestine:6.65 colon:6.33 liver/hepato:6.57 lung:6.93 bladder:- kidney:6.52 pituitary:6.45 thyroid/parathyroid:7.09 adrenal gland:6 pancreas:6.15 breast:6.95 salivary:6.06
CAGE uterus:3.92 placenta:4.14 prostate:3.71 ovary:3.66 testis:3.31 heart:3.48 muscle:3.75 esophagus:3.61 stomach:- intestine:3.71 colon:3.59     liver/hepato:3.62    lung:3.80 bladder:3.75 kidney:3.61 pituitary:4.07 thyroid/parathyroid:3.57 adrenal gland:- pancreas:3.16 breast:3.66 salivary:3.17
RNA-seq uterus:- placenta:- prostate:2.48 ovary:2.81 testis:3.04 heart:2.43 muscle:1.45 esophagus:- stomach:- intestine:- colon:2.45     liver/hepato:2.11        lung:2.42    bladder:- kidney:2.55 pituitary:- thyroid/parathyroid:2.49 adrenal gland:2.70 pancreas:- breast:2.76 salivary:-

IDs

Refseq ID NM_030621
Gene ID 23405
Unigene ID Hs.87889
Probe set ID 206061_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000100697
GTEx ID ENSG00000100697

Orthologous Gene

Mouse[2]  NM_148948
Rat[2]  NM_148948

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

8619474
9110174
10051563
10231032
10727850
10786632
12110183
12168954
12411504
12411505
12477932
12526743
12527779
12906857
14576312
14702039
14749716
15174051
15242644
15247924
15342556
15592455
15811921
15973356
15987463
16095561
16142218
16357216
16380083
16424907
16582496
17071602
17181864
17303335
17317629
17332367
17360756
17379831
17452327
17482383
17531811
17663774
18023283
18029348
18167183
18178619
18239938
18289125
18325616
18413723
18508075
18637735
18644891
18700235
18927112
18978195
19017633
19022417
19047128
19082437
19092150
19118902
19127773
19138993
19155329
19219043
19393748
19422693
19460752
19520829
19556464
19615732
19646895
19672267
19678941
19716330
19782670
19806572
19836333
19851984
19914350
20201926
20210522
20211803
20232482
20237275
20301471
20339536
20405249
20463238
20530258
20550935
20584909
20615407
20721975
20730047
20732906
20805302
20819778
20869963
20932845
20962848
20974746
21029372
21036787
21044367
21048142
21139048
21145461
21160068
21205968
21266384
21297615
21297638
21306637
21345667
21346072
21425145
21501861
21559780
21698147
21753850
21761362
21769619
21827717
21858095
21878538
21882293
21889945
21890473
21898071
21903422
21937200
21953080
21988832
22055188
22133720
22163034
22179432
22180160
22187960
22252463
22310293
22320315
22350415
22371183
22381205
22394132
22407237
22426548
22446887
22479364
22541070
22546613
22586326
22615744
22647351
22678362
22689055
22718634
22727743
22737231
22745131
22766726
22808238
22821364
22867905
22922797
22972926
22984192
22999255
23047949
23064648
23068969
23071822
23141545
23143396
23192594
23251602
23266047
23307239
23311378
23349018
23392577
23402259
23418872
23426981
23438482
23441612
23455922
23468895
23472152
23519840
23547758
23550157
23620094
23624860
23625684
23663110
23752268
23763383
23849790
23868280
23868705
23882114
24025624
24035498
24136150
24163352
24220032
24287487
24324261
24486018
24602972
24761742
24778252
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0001525  angiogenesis
GO:0006915  apoptosis
GO:0048754  branching morphogenesis of a tube
GO:0055013  cardiac muscle cell development
GO:0021987  cerebral cortex development
GO:0051607  defense response to virus
GO:0035116  embryonic hindlimb morphogenesis
GO:0010467  gene expression
GO:0071335  hair follicle cell proliferation
GO:0031069  hair follicle morphogenesis
GO:0060119  inner ear receptor cell development
GO:0060576  intestinal epithelial cell development
GO:0030324  lung development
GO:0035264  multicellular organism growth
GO:0032290  myelin formation in the peripheral nervous system
GO:0043066  negative regulation of apoptosis
GO:0010626  negative regulation of Schwann cell proliferation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0021675  nerve development
GO:0048812  neuron projection morphogenesis
GO:0021889  olfactory bulb interneuron differentiation
GO:0031643  positive regulation of myelination
GO:0014040  positive regulation of Schwann cell differentiation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0009791  post-embryonic development
GO:0031054  pre-microRNA processing
GO:0035196  production of miRNAs involved in gene silencing by miRNA
GO:0030422  production of siRNA involved in RNA interference
GO:0051726  regulation of cell cycle
GO:0070173  regulation of enamel mineralization
GO:0045664  regulation of neuron differentiation
GO:0048713  regulation of oligodendrocyte differentiation
GO:0045069  regulation of viral genome replication
GO:0021522  spinal cord motor neuron differentiation
GO:0051225  spindle assembly
GO:0048536  spleen development
GO:0019827  stem cell maintenance
GO:0030423  targeting of mRNA for destruction involved in RNA interference
GO:0010070  zygote asymmetric cell division

Cellular Component

GO:0005829  cytosol
GO:0016442  RNA-induced silencing complex

Molecular Function

GO:0005524  ATP binding
GO:0008026  ATP-dependent helicase activity
GO:0003725  double-stranded RNA binding
GO:0046872  metal ion binding
GO:0035198  miRNA binding
GO:0005515  protein binding
GO:0004525  ribonuclease III activity