hairy/enhancer-of-split related with YRPW motif 1

 jump to detail

Synonym

HES-related repressor protein 2, MGC1274, Hairy/enhancer-of-split related with YRPW motif 1, CHF-2, HRT-1, CHF2, HERP2, Cardiovascular helix-loop-helix factor 2, hairy/enhancer-of-split related with YRPW motif 1, Hairy and enhancer of split-related protein 1, HEY1, HESR1, OAF1, HESR-1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:109 cerebellum:113.30 brain stem:- corpus callosum/glia:175 pineal gland:296.70 peripheral nerve:214.70 spine:224.60 retina:- eye:23.50 artery/aorta:89.90 vein:- lymphnode:- peripheral blood:- spleen:37.80 thymus:- bone marrow:- adipose:121 bone:12.80 skin:4.80
GeneChip cerebrum:8.62 cerebellum:8.57 brain stem:8.33 corpus callosum/glia:7.99 pineal gland:- peripheral nerve:9.42 spine:8.65 retina:- eye:- artery/aorta:7.27 vein:7.42 lymphnode:6.79 peripheral blood:- spleen:6.34 thymus:6.88 bone marrow:6 adipose:7.58 bone:- skin:7.08
CAGE cerebrum:3.01 cerebellum:- brain stem:2.98 corpus callosum/glia:3.13 pineal gland:2.91 peripheral nerve:- spine:3.19 retina:- eye:- artery/aorta:2.05 vein:2.11 lymphnode:1.00 peripheral blood:- spleen:1.29 thymus:1.41 bone marrow:- adipose:2.91 bone:- skin:-
RNA-seq cerebrum:3.90 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.93 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.93 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:36.50 placenta:43.70 prostate:11.30 ovary:- testis:4.30 heart:25.50 muscle:40.20 esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:39.10    bladder:125.60 kidney:31.20 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:8.90 breast:- salivary:-
GeneChip uterus:6.74 placenta:8.32 prostate:6.53 ovary:5.99 testis:6.78 heart:8.09 muscle:7.75 esophagus:6.41 stomach:6.87 intestine:7.14 colon:7.11 liver/hepato:6 lung:7.90 bladder:- kidney:6.56 pituitary:8.74 thyroid/parathyroid:7.01 adrenal gland:5.89 pancreas:6.02 breast:7.51 salivary:5.87
CAGE uterus:1.94 placenta:3.07 prostate:2.46 ovary:0.86 testis:1.72 heart:2.62 muscle:3.08 esophagus:2.38 stomach:- intestine:1.20 colon:1.63     liver/hepato:1.66    lung:2.96 bladder:2.49 kidney:1.28 pituitary:2.70 thyroid/parathyroid:1.61 adrenal gland:- pancreas:0.58 breast:2.34 salivary:1.15
RNA-seq uterus:- placenta:- prostate:2.90 ovary:1.16 testis:3.42 heart:3.13 muscle:3.09 esophagus:- stomach:- intestine:- colon:2.99     liver/hepato:0.53        lung:3.09    bladder:- kidney:2.01 pituitary:- thyroid/parathyroid:1.83 adrenal gland:2.49 pancreas:- breast:3.04 salivary:-

Gene Information

IDs

Refseq ID NM_012258
Gene ID 23462
Unigene ID Hs.234434
Probe set ID 44783_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000164683
GTEx ID ENSG00000164683

Orthologous Gene

Mouse[1]  NM_010423
Rat [0]  

Chromosomal Region

8q21.13  [80,676,245  -  80,680,098]

Gene Family (Interpro ID)

IPR003650  Orange
IPR018352  Orange subgroup

Link to Pubmed  (Pubmed ID)

8125298
10403790
10415358
10692439
10860664
10964718
11095750
11279181
11486044
11486045
11585921
11866539
12453432
12477932
12548545
14702039
15231748
15314183
15342556
15485867
15489334
15680351
15684393
15749835
16043483
16165016
16344560
17028039
17259303
17496152
17611704
18239137
18363832
18986983
19322201
19369342
19453261
19802006
19857617
19917614
21290414
22034177
22036964
23226563
23252872
23379739
23900217
24124145
24366871

Gene Ontology  (GO ID)

Biological Process

GO:0001525  angiogenesis
GO:0009948  anterior/posterior axis specification
GO:0060842  arterial endothelial cell differentiation
GO:0003190  atrioventricular valve formation
GO:0060317  cardiac epithelial to mesenchymal transition
GO:0060411  cardiac septum morphogenesis
GO:0003208  cardiac ventricle morphogenesis
GO:0003203  endocardial cushion morphogenesis
GO:0003199  endocardial cushion to mesenchymal transition involved in valve formation
GO:0003198  epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0060347  heart trabecula formation
GO:0060716  labyrinthine layer blood vessel development
GO:0045746  negative regulation of Notch signaling pathway
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0007219  Notch signaling pathway
GO:0002076  osteoblast development
GO:0045669  positive regulation of osteoblast differentiation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0003184  pulmonary valve morphogenesis
GO:0001570  vasculogenesis
GO:0060412  ventricular septum morphogenesis
GO:0003222  ventricular trabecular myocardium morphogenesis

Cellular Component

GO:0005737  cytoplasm
GO:0005654  nucleoplasm
GO:0005634  nucleus

Molecular Function

GO:0005515  protein binding
GO:0046983  protein dimerization activity
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding