fyn-related kinase

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Synonym

FRK, PTK5, Tyrosine-protein kinase FRK, GTK, RAK, Nuclear tyrosine protein kinase RAK, fyn-related kinase, PTK5 protein tyrosine kinase 5

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:118.60 eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:12.90 bone marrow:19.70 adipose:- bone:12.80 skin:4.80
GeneChip cerebrum:2.76 cerebellum:2.73 brain stem:2.82 corpus callosum/glia:2.83 pineal gland:- peripheral nerve:2.77 spine:2.83 retina:- eye:- artery/aorta:3.41 vein:3.14 lymphnode:2.85 peripheral blood:- spleen:2.63 thymus:2.80 bone marrow:2.79 adipose:2.75 bone:- skin:2.89
CAGE cerebrum:0.23 cerebellum:- brain stem:0.51 corpus callosum/glia:0.13 pineal gland:0.14 peripheral nerve:- spine:0.39 retina:- eye:- artery/aorta:3.28 vein:1.10 lymphnode:1.32 peripheral blood:- spleen:0.80 thymus:0.80 bone marrow:- adipose:1.01 bone:- skin:-
RNA-seq cerebrum:0.39 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.40 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.24 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:3.60 prostate:- ovary:- testis:43.30 heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:10.60        lung:4.90    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:17.80 breast:18.60 salivary:-
GeneChip uterus:2.92 placenta:2.69 prostate:3.12 ovary:2.97 testis:2.86 heart:2.89 muscle:2.88 esophagus:3.05 stomach:2.89 intestine:2.82 colon:2.76 liver/hepato:3.24 lung:2.65 bladder:- kidney:3.24 pituitary:2.85 thyroid/parathyroid:2.81 adrenal gland:2.73 pancreas:2.93 breast:2.84 salivary:3
CAGE uterus:1.78 placenta:1.32 prostate:1.78 ovary:1.25 testis:0.57 heart:1.22 muscle:1.00 esophagus:2.56 stomach:- intestine:3.89 colon:2.79     liver/hepato:3.05    lung:2.11 bladder:1.84 kidney:3.33 pituitary:1.72 thyroid/parathyroid:0.32 adrenal gland:- pancreas:1.87 breast:0.55 salivary:2.78
RNA-seq uterus:- placenta:- prostate:0.96 ovary:0.60 testis:2.16 heart:1.46 muscle:0.82 esophagus:- stomach:- intestine:- colon:0.38     liver/hepato:1.62        lung:0.75    bladder:- kidney:2.73 pituitary:- thyroid/parathyroid:0.29 adrenal gland:0.54 pancreas:- breast:0.67 salivary:-

Gene Information

IDs

Refseq ID NM_002031
Gene ID 2444
Unigene ID Hs.89426
Probe set ID 207178_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000111816
GTEx ID ENSG00000111816

Orthologous Gene

Mouse[6]  NM_001159544, NM_010237
Rat [0]  

Chromosomal Region

6q22.1  [116,262,693  -  116,381,921]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

7510261
7664264
7696183
8099900
10229084
12477932
12569567
12725532
12750000
15082191
15489334
15951569
19056867
19345329
20686565
20800603
21074287
21665990
22745667
22790444
22939624
23263486
23267173
23318459
23455922
24097068

Gene Ontology  (GO ID)

Biological Process

GO:0030154  cell differentiation
GO:0008285  negative regulation of cell proliferation
GO:0006468  protein amino acid phosphorylation

Cellular Component

GO:0005737  cytoplasm
GO:0005622  intracellular
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0004715  non-membrane spanning protein tyrosine kinase activity
GO:0005515  protein binding