3-ketodihydrosphingosine reductase

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Synonym

KDS reductase, FVT1, FVT-1, 3-dehydrosphinganine reductase, follicular lymphoma variant translocation 1, Follicular variant translocation protein 1, 3-ketodihydrosphingosine reductase precursor

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:107.80 cerebellum:163.70 brain stem:- corpus callosum/glia:145.80 pineal gland:- peripheral nerve:61.30 spine:- retina:- eye:41.10 artery/aorta:149.90 vein:- lymphnode:111.20 peripheral blood:164 spleen:18.90 thymus:116 bone marrow:19.70 adipose:40.30 bone:204.70 skin:81.60
GeneChip cerebrum:8.13 cerebellum:7.61 brain stem:8.29 corpus callosum/glia:8.76 pineal gland:- peripheral nerve:8.53 spine:8.83 retina:- eye:- artery/aorta:8.36 vein:8.12 lymphnode:7.77 peripheral blood:- spleen:7.67 thymus:7.34 bone marrow:6.32 adipose:8.16 bone:- skin:8.29
CAGE cerebrum:3.82 cerebellum:- brain stem:4.31 corpus callosum/glia:4.39 pineal gland:3.60 peripheral nerve:- spine:4.45 retina:- eye:- artery/aorta:4.42 vein:3.59 lymphnode:3.58 peripheral blood:- spleen:3.32 thymus:3.23 bone marrow:- adipose:4.25 bone:- skin:-
RNA-seq cerebrum:3.81 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.97 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.38 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:173.20 placenta:98.40 prostate:90.10 ovary:37.30 testis:51.90 heart:76.60 muscle:- esophagus:- stomach:382.40 intestine:259.20 colon:101.80     liver/hepato:52.80        lung:53.80    bladder:125.60 kidney:83.20 pituitary:116 thyroid/parathyroid:- adrenal gland:- pancreas:17.80 breast:130.10 salivary:328.40
GeneChip uterus:8.10 placenta:8.10 prostate:8.23 ovary:8.22 testis:7 heart:8.06 muscle:7.18 esophagus:8.20 stomach:7.79 intestine:7.53 colon:7.62 liver/hepato:8.81 lung:8.02 bladder:- kidney:8.16 pituitary:7.63 thyroid/parathyroid:8.43 adrenal gland:8.30 pancreas:6.85 breast:8.62 salivary:7.65
CAGE uterus:4.05 placenta:4.30 prostate:4.17 ovary:4.11 testis:3.62 heart:3.95 muscle:3.30 esophagus:3.95 stomach:- intestine:3.75 colon:3.85     liver/hepato:4.98    lung:4.01 bladder:4.18 kidney:3.84 pituitary:3.51 thyroid/parathyroid:4.17 adrenal gland:- pancreas:3.59 breast:4.62 salivary:3.21
RNA-seq uterus:- placenta:- prostate:4.50 ovary:4.12 testis:3.67 heart:2.80 muscle:2.70 esophagus:- stomach:- intestine:- colon:4.43     liver/hepato:4.00        lung:3.91    bladder:- kidney:3.96 pituitary:- thyroid/parathyroid:4.08 adrenal gland:3.50 pancreas:- breast:4.06 salivary:-

Gene Information

IDs

Refseq ID NM_002035
Gene ID 2531
Unigene ID Hs.74050
Probe set ID 202419_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000119537
GTEx ID ENSG00000119537

Orthologous Gene

Mouse[1]  NM_027534
Rat[1]  NM_001108342

Chromosomal Region

18q21.33  [60,994,971  -  61,034,743]

Gene Family (Interpro ID)

IPR003560  2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
IPR002347  Glucose/ribitol dehydrogenase
IPR002198  Short-chain dehydrogenase/reductase SDR

Link to Pubmed  (Pubmed ID)

7949096
8417785
12477932
12960700
14702039
15328338
15364918
15489334
16711541
17420465
18395445
19019774
19027726
19322201
19773279
19946888
20855565
21988832
23000965

Gene Ontology  (GO ID)

Biological Process

GO:0006666  3-keto-sphinganine metabolic process
GO:0030148  sphingolipid biosynthetic process
GO:0006665  sphingolipid metabolic process

Cellular Component

GO:0005783  endoplasmic reticulum
GO:0005789  endoplasmic reticulum membrane
GO:0005615  extracellular space
GO:0016021  integral to membrane

Molecular Function

GO:0047560  3-dehydrosphinganine reductase activity