protein kinase D2

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Synonym

PKD2, DKFZP586E0820, Serine/threonine-protein kinase D2, HSPC187, protein kinase D2, PRKD2, nPKC-D2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:28.40 cerebellum:88.20 brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:122.70 spine:- retina:- eye:47 artery/aorta:119.90 vein:66.60 lymphnode:101.10 peripheral blood:72.90 spleen:453.80 thymus:592.70 bone marrow:- adipose:40.30 bone:102.40 skin:76.80
GeneChip cerebrum:6.07 cerebellum:5.68 brain stem:5.98 corpus callosum/glia:6.28 pineal gland:- peripheral nerve:6.72 spine:6.23 retina:- eye:- artery/aorta:7.36 vein:6.86 lymphnode:9.01 peripheral blood:- spleen:9.25 thymus:8.47 bone marrow:7.87 adipose:7.81 bone:- skin:7.92
CAGE cerebrum:2.11 cerebellum:- brain stem:2.43 corpus callosum/glia:2.66 pineal gland:2.83 peripheral nerve:- spine:2.74 retina:- eye:- artery/aorta:3.58 vein:4.44 lymphnode:4.12 peripheral blood:- spleen:4.17 thymus:4.33 bone marrow:- adipose:3.60 bone:- skin:-
RNA-seq cerebrum:0.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.96 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:100.20 placenta:65.60 prostate:135.20 ovary:37.30 testis:64.90 heart:25.50 muscle:- esophagus:- stomach:42.50 intestine:97.20 colon:42.40     liver/hepato:10.60        lung:102.60    bladder:125.60 kidney:31.20 pituitary:- thyroid/parathyroid:327.50 adrenal gland:- pancreas:26.70 breast:195.20 salivary:-
GeneChip uterus:7.32 placenta:7.73 prostate:7.23 ovary:7.47 testis:6.70 heart:6.70 muscle:5.93 esophagus:8 stomach:7.81 intestine:7.11 colon:7.67 liver/hepato:6.83 lung:8.34 bladder:- kidney:7.05 pituitary:7.44 thyroid/parathyroid:7.95 adrenal gland:7.08 pancreas:6.35 breast:8.27 salivary:7.41
CAGE uterus:3.67 placenta:3.70 prostate:3.47 ovary:3.61 testis:2.71 heart:3.28 muscle:2.63 esophagus:3.94 stomach:- intestine:3.69 colon:3.53     liver/hepato:2.83    lung:3.86 bladder:3.66 kidney:3.17 pituitary:3.28 thyroid/parathyroid:3.57 adrenal gland:- pancreas:2.66 breast:3.69 salivary:3.27
RNA-seq uterus:- placenta:- prostate:0.00 ovary:0.00 testis:0.25 heart:0.00 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.42     liver/hepato:0.46        lung:0.99    bladder:- kidney:0.68 pituitary:- thyroid/parathyroid:0.46 adrenal gland:0.55 pancreas:- breast:0.80 salivary:-

Gene Information

IDs

Refseq ID NM_001079881
Gene ID 25865
Unigene ID Hs.466987
Probe set ID 38269_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000105287
GTEx ID ENSG00000105287

Orthologous Gene

Mouse[3]  NM_178900
Rat[1]  NM_001013895

Chromosomal Region

19q13.32  [47,177,574  -  47,220,384]

Gene Family (Interpro ID)

IPR001849  Pleckstrin homology
IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

11042152
11062248
12058027
12477932
12646243
14702039
14743217
15231748
15604256
15623513
15975900
16083285
16344560
16899224
16928771
17077180
17081983
17121608
17192257
17570131
17951978
17962809
18059339
18262756
18440775
18758461
19001381
19192391
19430480
19520973
19581308
19615732
19913121
20332261
20553269
20628086
20731705
20732914
20855867
21081666
21139048
21173164
21736870
21865166
21890473
21900206
22217708
22734003
22939624
23251465
23393329
23515950
23562655

Gene Ontology  (GO ID)

Biological Process

GO:0001525  angiogenesis
GO:0007155  cell adhesion
GO:0008219  cell death
GO:0018105  peptidyl-serine phosphorylation
GO:0045766  positive regulation of angiogenesis
GO:0043536  positive regulation of blood vessel endothelial cell migration
GO:0045785  positive regulation of cell adhesion
GO:0032793  positive regulation of CREB transcription factor activity
GO:0010595  positive regulation of endothelial cell migration
GO:0001938  positive regulation of endothelial cell proliferation
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0045743  positive regulation of fibroblast growth factor receptor signaling pathway
GO:0032743  positive regulation of interleukin-2 production
GO:0032757  positive regulation of interleukin-8 production
GO:0051092  positive regulation of NF-kappaB transcription factor activity
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0010740  positive regulation of protein kinase cascade
GO:0050862  positive regulation of T cell receptor signaling pathway
GO:0051091  positive regulation of transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0030949  positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0046777  protein amino acid autophosphorylation
GO:0006468  protein amino acid phosphorylation
GO:0007243  protein kinase cascade
GO:0050852  T cell receptor signaling pathway
GO:0048010  vascular endothelial growth factor receptor signaling pathway

Cellular Component

GO:0005737  cytoplasm
GO:0005794  Golgi apparatus
GO:0005622  intracellular
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0046872  metal ion binding
GO:0005543  phospholipid binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004697  protein kinase C activity
GO:0004674  protein serine/threonine kinase activity