growth arrest-specific 6

 jump to detail

Synonym

growth arrest-specific 6, Growth-arrest-specific protein 6 precursor, GAS6, AXSF, DKFZp666G247, AXLLG, GAS-6

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:8.52 cerebellum:8.56 brain stem:8.64 corpus callosum/glia:8.41 pineal gland:- peripheral nerve:9.21 spine:8.50 retina:- eye:- artery/aorta:10.23 vein:9.83 lymphnode:8.95 peripheral blood:- spleen:8.28 thymus:8.55 bone marrow:8.33 adipose:9.30 bone:- skin:8.97
CAGE cerebrum:3.72 cerebellum:- brain stem:3.96 corpus callosum/glia:3.52 pineal gland:2.95 peripheral nerve:- spine:3.90 retina:- eye:- artery/aorta:6.26 vein:4.54 lymphnode:3.67 peripheral blood:- spleen:3.04 thymus:3.54 bone marrow:- adipose:4.15 bone:- skin:-
RNA-seq cerebrum:0.94 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.92 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.11 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:9.67 placenta:8.52 prostate:8.55 ovary:9.86 testis:9.26 heart:9.57 muscle:8.62 esophagus:8.93 stomach:9.12 intestine:9.06 colon:9.23 liver/hepato:8.27 lung:9.59 bladder:- kidney:9.17 pituitary:9.18 thyroid/parathyroid:9.52 adrenal gland:8.95 pancreas:8.94 breast:9.58 salivary:8.95
CAGE uterus:5.26 placenta:3.73 prostate:4.95 ovary:4.75 testis:4.79 heart:5.14 muscle:4.48 esophagus:4.63 stomach:- intestine:4.04 colon:4.43     liver/hepato:3.89    lung:4.63 bladder:4.88 kidney:4.07 pituitary:3.79 thyroid/parathyroid:4.65 adrenal gland:- pancreas:3.90 breast:4.97 salivary:4.23
RNA-seq uterus:- placenta:- prostate:2.89 ovary:1.71 testis:1.60 heart:0.78 muscle:0.31 esophagus:- stomach:- intestine:- colon:1.38     liver/hepato:1.47        lung:1.24    bladder:- kidney:0.77 pituitary:- thyroid/parathyroid:1.99 adrenal gland:2.23 pancreas:- breast:1.96 salivary:-

Gene Information

IDs

Refseq ID NM_001143945
Gene ID 2621
Unigene ID Hs.646346
Probe set ID 1598_g_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000183087
GTEx ID ENSG00000183087

Orthologous Gene

Mouse[1]  NM_019521
Rat [0]  

Chromosomal Region

13q34  [114,523,524  -  114,567,046]

Gene Family (Interpro ID)

IPR008985  Concanavalin A-like lectin/glucanase
IPR013320  Concanavalin A-like lectin/glucanase, subgroup
IPR001881  EGF-like calcium-binding
IPR000742  EGF-like, type 3
IPR000294  Gamma-carboxyglutamic acid-rich (GLA) domain
IPR001791  Laminin G

Link to Pubmed  (Pubmed ID)

7634325
7854420
7867073
8336730
8595896
8604045
8621659
8637702
8939948
9259426
9326368
9326369
9367994
10954847
11175853
12029073
12218057
12477932
12490074
12764109
12768229
14702039
14750094
15108283
15130893
15184064
15452374
15489334
15507525
15605394
15958209
16344560
16359517
16362042
16556867
16564713
16723520
16999853
17721624
17897008
18172262
18174285
18395422
18570189
18680538
18760998
18840707
19132213
19369636
19567592
19657094
19696043
19744001
19888345
19922767
19965679
20048160
20088931
20103767
20126470
20417630
20504897
20546121
20664904
20922806
21067537
21139048
21278074
21343401
21501828
21638224
21959217
22072012
22363695
22516347
22763415
22833165
22907951
22914895
23209669
23318455
23318499
23341490
23419144
23430954
23567973
23570341
23684620
23684948
23781120
23826128
23878800
24233839
24567414

Gene Ontology  (GO ID)

Biological Process

GO:0032148  activation of protein kinase B activity
GO:0043277  apoptotic cell clearance
GO:0007596  blood coagulation
GO:0070588  calcium ion transmembrane transport
GO:0007155  cell adhesion
GO:0007050  cell cycle arrest
GO:0016477  cell migration
GO:0008283  cell proliferation
GO:0031589  cell-substrate adhesion
GO:0044267  cellular protein metabolic process
GO:0071333  cellular response to glucose stimulus
GO:0071363  cellular response to growth factor stimulus
GO:0009267  cellular response to starvation
GO:0071307  cellular response to vitamin K
GO:0046718  entry of virus into host cell
GO:0007167  enzyme linked receptor protein signaling pathway
GO:0050900  leukocyte migration
GO:0010934  macrophage cytokine production
GO:0043066  negative regulation of apoptosis
GO:0070168  negative regulation of biomineral formation
GO:0043154  negative regulation of caspase activity
GO:0032689  negative regulation of interferon-gamma production
GO:0050711  negative regulation of interleukin-1 secretion
GO:0032715  negative regulation of interleukin-6 production
GO:0033159  negative regulation of protein import into nucleus, translocation
GO:0043433  negative regulation of transcription factor activity
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0032720  negative regulation of tumor necrosis factor production
GO:0010804  negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0001764  neuron migration
GO:0031100  organ regeneration
GO:0017187  peptidyl-glutamic acid carboxylation
GO:0018105  peptidyl-serine phosphorylation
GO:0006909  phagocytosis
GO:0030168  platelet activation
GO:0070527  platelet aggregation
GO:0002576  platelet degranulation
GO:0001961  positive regulation of cytokine-mediated signaling pathway
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0048146  positive regulation of fibroblast proliferation
GO:0010628  positive regulation of gene expression
GO:0003104  positive regulation of glomerular filtration
GO:0032825  positive regulation of natural killer cell differentiation
GO:0033138  positive regulation of peptidyl-serine phosphorylation
GO:0050766  positive regulation of phagocytosis
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0046827  positive regulation of protein export from nucleus
GO:0045860  positive regulation of protein kinase activity
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0032008  positive regulation of TOR signaling pathway
GO:0043687  post-translational protein modification
GO:0006468  protein amino acid phosphorylation
GO:0043491  protein kinase B signaling cascade
GO:0006508  proteolysis
GO:0040008  regulation of growth
GO:0007165  signal transduction
GO:0019064  viral envelope fusion with host membrane
GO:0019079  viral genome replication
GO:0046813  virion attachment, binding of host cell surface receptor

Cellular Component

GO:0005737  cytoplasm
GO:0005788  endoplasmic reticulum lumen
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0005796  Golgi lumen
GO:0031093  platelet alpha granule lumen

Molecular Function

GO:0005509  calcium ion binding
GO:0043027  caspase inhibitor activity
GO:0060090  molecular adaptor activity
GO:0001786  phosphatidylserine binding
GO:0005515  protein binding
GO:0030296  protein tyrosine kinase activator activity
GO:0048018  receptor agonist activity
GO:0005102  receptor binding
GO:0030971  receptor tyrosine kinase binding
GO:0005245  voltage-gated calcium channel activity