glucokinase (hexokinase 4)

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Synonym

Hexokinase type IV, Hexokinase-4, GCK, Hexokinase-D, HXKP, Glucokinase, GLK, HHF3, MODY2, HK4, HKIV, HK IV

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:-

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:-

bone:-

skin:-

GeneChip

cerebrum:6.03

cerebellum:6.08

brain stem:6.25

corpus callosum/glia:5.90

pineal gland:-

peripheral nerve:5.60

spine:5.82

retina:-

eye:-

artery/aorta:5.72

vein:5.84

lymphnode:5.57

peripheral blood:-

spleen:5.53

thymus:5.58

bone marrow:5.62

adipose:5.61

bone:-

skin:5.71

CAGE

cerebrum:0.24

cerebellum:-

brain stem:0

corpus callosum/glia:0.29

pineal gland:0.21

peripheral nerve:-

spine:0.30

retina:-

eye:-

artery/aorta:0

vein:0

lymphnode:0

peripheral blood:-

spleen:0

thymus:0

bone marrow:-

adipose:0

bone:-

skin:-

RNA-seq

cerebrum:0.00

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.00

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.00

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:-

prostate:11.30

ovary:-

testis:-

heart:-

muscle:-

esophagus:-

stomach:-

intestine:-

colon:33.90

liver/hepato:-

lung:-

bladder:-

kidney:561.40

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

GeneChip

uterus:5.62

placenta:5.45

prostate:5.32

ovary:5.65

testis:5.46

heart:5.92

muscle:5.71

esophagus:5.58

stomach:5.65

intestine:5.71

colon:5.88

liver/hepato:6.15

lung:5.42

bladder:-

kidney:5.62

pituitary:7.21

thyroid/parathyroid:5.38

adrenal gland:5.56

pancreas:6.39

breast:5.55

salivary:5.64

CAGE

uterus:0

placenta:0

prostate:0

ovary:0

testis:0

heart:0

muscle:0

esophagus:0

stomach:-

intestine:0

colon:0.21

liver/hepato:0.26

lung:0

bladder:0

kidney:0

pituitary:3.09

thyroid/parathyroid:0

adrenal gland:-

pancreas:0.58

breast:0

salivary:0

RNA-seq

uterus:-

placenta:-

prostate:0.00

ovary:0.00

testis:0.00

heart:0.00

muscle:0.00

esophagus:-

stomach:-

intestine:-

colon:0.00

liver/hepato:0.00

lung:0.00

bladder:-

kidney:0.00

pituitary:-

thyroid/parathyroid:0.21

adrenal gland:0.00

pancreas:-

breast:0.00

salivary:-

IDs

Refseq ID	NM_000162
Gene ID	2645
Unigene ID	Hs.127011
Probe set ID	211167_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000106633
GTEx ID	ENSG00000106633

Orthologous Gene

Mouse[2]	NM_010292
Rat [0]

Chromosomal Region

7p13 [44,183,872 - 44,237,769]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0070509	calcium ion import
GO:0005975	carbohydrate metabolic process
GO:0001678	cellular glucose homeostasis
GO:0042149	cellular response to glucose starvation
GO:0032869	cellular response to insulin stimulus
GO:0051594	detection of glucose
GO:0007204	elevation of cytosolic calcium ion concentration
GO:0031018	endocrine pancreas development
GO:0006003	fructose 2,6-bisphosphate metabolic process
GO:0042593	glucose homeostasis
GO:0015758	glucose transport
GO:0005978	glycogen biosynthetic process
GO:0006096	glycolysis
GO:0008645	hexose transport
GO:0006739	NADP metabolic process
GO:0032811	negative regulation of epinephrine secretion
GO:0045721	negative regulation of gluconeogenesis
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0045821	positive regulation of glycolysis
GO:0032024	positive regulation of insulin secretion
GO:0042327	positive regulation of phosphorylation
GO:0010827	regulation of glucose transport
GO:0006110	regulation of glycolysis
GO:0050796	regulation of insulin secretion
GO:0043266	regulation of potassium ion transport
GO:0019932	second-messenger-mediated signaling
GO:0055085	transmembrane transport

Cellular Component

GO:0005938	cell cortex
GO:0005829	cytosol
GO:0005739	mitochondrion
GO:0005654	nucleoplasm
GO:0030141	secretory granule

Molecular Function

GO:0043531	ADP binding
GO:0005524	ATP binding
GO:0008865	fructokinase activity
GO:0004340	glucokinase activity
GO:0005536	glucose binding
GO:0000287	magnesium ion binding
GO:0019158	mannokinase activity
GO:0005515	protein binding
GO:0019903	protein phosphatase binding

glucokinase (hexokinase 4)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function