glucokinase (hexokinase 4)

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Synonym

Hexokinase type IV, Hexokinase-4, GCK, Hexokinase-D, HXKP, Glucokinase, GLK, HHF3, MODY2, HK4, HKIV, HK IV

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:6.03 cerebellum:6.08 brain stem:6.25 corpus callosum/glia:5.90 pineal gland:- peripheral nerve:5.60 spine:5.82 retina:- eye:- artery/aorta:5.72 vein:5.84 lymphnode:5.57 peripheral blood:- spleen:5.53 thymus:5.58 bone marrow:5.62 adipose:5.61 bone:- skin:5.71
CAGE cerebrum:0.24 cerebellum:- brain stem:0 corpus callosum/glia:0.29 pineal gland:0.21 peripheral nerve:- spine:0.30 retina:- eye:- artery/aorta:0 vein:0 lymphnode:0 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.78 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.38 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.16 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:11.30 ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:33.90     liver/hepato:-        lung:-    bladder:- kidney:561.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:5.62 placenta:5.45 prostate:5.32 ovary:5.65 testis:5.46 heart:5.92 muscle:5.71 esophagus:5.58 stomach:5.65 intestine:5.71 colon:5.88 liver/hepato:6.15 lung:5.42 bladder:- kidney:5.62 pituitary:7.21 thyroid/parathyroid:5.38 adrenal gland:5.56 pancreas:6.39 breast:5.55 salivary:5.64
CAGE uterus:0 placenta:0 prostate:0 ovary:0 testis:0 heart:0 muscle:0 esophagus:0 stomach:- intestine:0 colon:0.21     liver/hepato:0.26    lung:0 bladder:0 kidney:0 pituitary:3.09 thyroid/parathyroid:0 adrenal gland:- pancreas:0.58 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0.48 ovary:0.73 testis:0.24 heart:0.23 muscle:0.14 esophagus:- stomach:- intestine:- colon:0.14     liver/hepato:0.40        lung:0.14    bladder:- kidney:0.15 pituitary:- thyroid/parathyroid:0.00 adrenal gland:0.32 pancreas:- breast:0.08 salivary:-

IDs

Refseq ID NM_033507
Gene ID 2645
Unigene ID Hs.127011
Probe set ID 211167_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000106633
GTEx ID ENSG00000106633

Orthologous Gene

Mouse[2]  NM_010292
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

1303265
1349989
1354840
1360036
1397713
1464666
1502186
1511800
1545870
1570017
1612194
1740341
1740342
1871135
8094163
8094164
8132752
8168652
8194664
8325892
8376578
8433729
8446612
8454109
8495817
8549853
8626423
8878425
9000692
9049484
9270716
9435328
9469993
9570959
9662401
10588527
10601273
10694920
11106831
11112984
11237213
11372010
11440371
11473043
11522786
11756407
11772903
11914755
12050210
12101177
12442280
12477932
12515438
12627330
12690205
12941786
14517946
14578306
14617577
14627435
14702039
14747279
15009676
15173029
15277402
15305805
15489334
15677479
15677518
15841481
15918042
15928245
15987895
16173921
16186409
16331569
16344560
16378108
16444761
16632067
16752173
16936201
16963153
17070428
17082186
17186219
17186458
17216282
17260972
17327436
17389332
17561510
17573900
17584736
17937063
17976205
17994217
18008060
18039179
18159847
18184897
18187620
18196929
18208578
18248649
18271687
18298419
18322640
18325809
18332101
18370929
18382660
18397317
18399931
18411240
18450771
18483479
18498634
18556336
18571549
18588509
18651836
18672310
18805788
18809676
18811724
18828733
19002431
19018513
19060907
19073768
19096518
19125755
19146401
19150152
19169489
19187021
19228875
19241058
19282865
19336674
19358091
19368707
19410318
19411616
19459610
19473033
19515026
19533084
19551638
19564454
19578796
19617908
19643913
19651812
19741163
19741166
19790256
19884385
19913121
19934346
19937311
19948975
20015564
20081858
20132997
20144192
20164212
20185807
20227404
20301549
20301620
20337973
20458967
20490451
20536962
20587714
20628086
20628598
20668700
20682687
20682688
20828143
20845477
20849852
20858683
20878480
20889853
20979768
21036910
21104275
21348868
21420961
21437567
21454584
21518409
21544516
21604084
21720051
21909109
21978167
22038520
22043488
22060211
22096510
22177951
22291974
22298776
22332836
22335469
22341299
22399527
22432108
22493702
22517333
22540858
22581228
22611063
22653590
22761713
22820548
23009393
23029263
23085272
23139355
23155715
23271955
23433541
23441155
23575436
23586928
23733961
23840762
23878349
23957911
24244560
24430320
24447338
24568320

Gene Ontology  (GO ID)

Biological Process

GO:0070509  calcium ion import
GO:0005975  carbohydrate metabolic process
GO:0001678  cellular glucose homeostasis
GO:0042149  cellular response to glucose starvation
GO:0032869  cellular response to insulin stimulus
GO:0051594  detection of glucose
GO:0007204  elevation of cytosolic calcium ion concentration
GO:0031018  endocrine pancreas development
GO:0006003  fructose 2,6-bisphosphate metabolic process
GO:0042593  glucose homeostasis
GO:0015758  glucose transport
GO:0005978  glycogen biosynthetic process
GO:0006096  glycolysis
GO:0008645  hexose transport
GO:0006739  NADP metabolic process
GO:0032811  negative regulation of epinephrine secretion
GO:0045721  negative regulation of gluconeogenesis
GO:0045725  positive regulation of glycogen biosynthetic process
GO:0045821  positive regulation of glycolysis
GO:0032024  positive regulation of insulin secretion
GO:0042327  positive regulation of phosphorylation
GO:0010827  regulation of glucose transport
GO:0006110  regulation of glycolysis
GO:0050796  regulation of insulin secretion
GO:0043266  regulation of potassium ion transport
GO:0019932  second-messenger-mediated signaling
GO:0055085  transmembrane transport

Cellular Component

GO:0005938  cell cortex
GO:0005829  cytosol
GO:0005739  mitochondrion
GO:0005654  nucleoplasm
GO:0030141  secretory granule

Molecular Function

GO:0043531  ADP binding
GO:0005524  ATP binding
GO:0008865  fructokinase activity
GO:0004340  glucokinase activity
GO:0005536  glucose binding
GO:0000287  magnesium ion binding
GO:0019158  mannokinase activity
GO:0005515  protein binding
GO:0019903  protein phosphatase binding