eukaryotic translation initiation factor 2C, 2

Synonym

Slicer protein, eukaryotic translation initiation factor 2C, 2, Eukaryotic translation initiation factor 2C 2, eIF2C 2, MGC3183, PAZ Piwi domain protein, eIF-2C 2, EIF2C2, Argonaute-2, AGO2, Q10

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:20.10

cerebellum:12.60

brain stem:-

corpus callosum/glia:29.20

pineal gland:148.30

peripheral nerve:184

spine:112.30

retina:-

eye:94

artery/aorta:60

vein:66.60

lymphnode:141.50

peripheral blood:36.40

spleen:18.90

thymus:64.40

bone marrow:78.70

adipose:40.30

bone:12.80

skin:91.20

GeneChip

nodata

CAGE

cerebrum:3.21

cerebellum:-

brain stem:3.30

corpus callosum/glia:3.55

pineal gland:3.28

peripheral nerve:-

spine:3.57

retina:-

eye:-

artery/aorta:4.08

vein:3.22

lymphnode:3.32

peripheral blood:-

spleen:2.94

thymus:3.33

bone marrow:-

adipose:3.08

bone:-

skin:-

RNA-seq

cerebrum:1.47

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.38

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.32

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:27.30

placenta:83.80

prostate:67.60

ovary:149.10

testis:8.70

heart:63.90

muscle:-

esophagus:-

stomach:42.50

intestine:-

colon:135.70

liver/hepato:105.60

lung:53.80

bladder:-

kidney:20.80

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:17.80

breast:92.90

salivary:-

GeneChip

nodata

CAGE

uterus:3.02

placenta:3.23

prostate:3.03

ovary:3.32

testis:2.61

heart:3.61

muscle:3.55

esophagus:3.06

stomach:-

intestine:2.88

colon:3.43

liver/hepato:2.52

lung:3.56

bladder:3.44

kidney:2.30

pituitary:3.23

thyroid/parathyroid:2.66

adrenal gland:-

pancreas:3.06

breast:4.29

salivary:2.69

RNA-seq

uterus:-

placenta:-

prostate:1.60

ovary:1.41

testis:1.57

heart:1.75

muscle:4.10

esophagus:-

stomach:-

intestine:-

colon:1.78

liver/hepato:0.84

lung:2.54

bladder:-

kidney:0.77

pituitary:-

thyroid/parathyroid:2.48

adrenal gland:1.51

pancreas:-

breast:1.11

salivary:-

IDs

Refseq ID	NM_012154
Gene ID	27161
Unigene ID	Hs.449415
Probe set ID	-
Ensembl ID	ENSG00000123908
GTEx ID	ENSG00000123908

Orthologous Gene

Mouse[1]	NM_153178
Rat[1]	NM_021597

Chromosomal Region

8q24.3 [141,541,264 - 141,645,718]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR012337	Polynucleotidyl transferase, ribonuclease H fold
IPR003165	Stem cell self-renewal protein Piwi

Gene Ontology (GO ID)

Biological Process

GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0010467	gene expression
GO:0031047	gene silencing by RNA
GO:0045087	innate immune response
GO:0035279	mRNA cleavage involved in gene silencing by miRNA
GO:0035278	negative regulation of translation involved in gene silencing by miRNA
GO:0045947	negative regulation of translational initiation
GO:0048011	nerve growth factor receptor signaling pathway
GO:0007219	Notch signaling pathway
GO:0048015	phosphoinositide-mediated signaling
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0009791	post-embryonic development
GO:0031054	pre-microRNA processing
GO:0006355	regulation of transcription, DNA-dependent
GO:0006351	transcription, DNA-dependent
GO:0006412	translation
GO:0006413	translational initiation

Cellular Component

GO:0005737	cytoplasm
GO:0000932	cytoplasmic mRNA processing body
GO:0005829	cytosol
GO:0035068	micro-ribonucleoprotein complex
GO:0005845	mRNA cap binding complex
GO:0005634	nucleus
GO:0005844	polysome
GO:0030529	ribonucleoprotein complex
GO:0016442	RNA-induced silencing complex

Molecular Function

GO:0004521	endoribonuclease activity
GO:0070551	endoribonuclease activity, cleaving siRNA-paired mRNA
GO:0046872	metal ion binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0000340	RNA 7-methylguanosine cap binding
GO:0035197	siRNA binding
GO:0003743	translation initiation factor activity

eukaryotic translation initiation factor 2C, 2

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function