disrupted in schizophrenia 1

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Synonym

disrupted in schizophrenia 1, KIAA0457, DISC1, Disrupted in schizophrenia 1 protein

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:29.60

cerebellum:37.80

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:30.70

spine:-

retina:-

eye:11.80

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:18.20

spleen:18.90

thymus:25.80

bone marrow:-

adipose:40.30

bone:25.60

skin:33.60

GeneChip

cerebrum:5.70

cerebellum:5.06

brain stem:5.74

corpus callosum/glia:5.97

pineal gland:-

peripheral nerve:6.79

spine:5.95

retina:-

eye:-

artery/aorta:5.27

vein:5.25

lymphnode:5.59

peripheral blood:-

spleen:5.61

thymus:4.89

bone marrow:5.59

adipose:5.40

bone:-

skin:5.13

CAGE

cerebrum:1.89

cerebellum:-

brain stem:2.36

corpus callosum/glia:2.73

pineal gland:3.57

peripheral nerve:-

spine:2.30

retina:-

eye:-

artery/aorta:1.88

vein:1.98

lymphnode:2.25

peripheral blood:-

spleen:2.00

thymus:1.73

bone marrow:-

adipose:1.69

bone:-

skin:-

RNA-seq

cerebrum:0.21

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.41

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.55

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:18.20

placenta:25.50

prostate:349.20

ovary:-

testis:47.60

heart:12.80

muscle:-

esophagus:-

stomach:-

intestine:64.80

colon:25.40

liver/hepato:10.60

lung:29.30

bladder:-

kidney:10.40

pituitary:-

thyroid/parathyroid:-

adrenal gland:50.80

pancreas:17.80

breast:65.10

salivary:-

GeneChip

uterus:5.36

placenta:6.36

prostate:5.01

ovary:5.75

testis:4.66

heart:5.55

muscle:5.33

esophagus:4.94

stomach:5.41

intestine:5.56

colon:5.67

liver/hepato:5.25

lung:5.32

bladder:-

kidney:5.36

pituitary:5.10

thyroid/parathyroid:5.12

adrenal gland:5.53

pancreas:4.98

breast:5.32

salivary:5.75

CAGE

uterus:1.78

placenta:1.99

prostate:1.82

ovary:1.92

testis:0.84

heart:1.58

muscle:0.79

esophagus:1.44

stomach:-

intestine:0.96

colon:1.63

liver/hepato:1.37

lung:1.73

bladder:1.02

kidney:1.09

pituitary:1.29

thyroid/parathyroid:1.13

adrenal gland:-

pancreas:0.94

breast:2.47

salivary:1.49

RNA-seq

uterus:-

placenta:-

prostate:0.36

ovary:1.36

testis:0.00

heart:0.12

muscle:0.18

esophagus:-

stomach:-

intestine:-

colon:0.00

liver/hepato:0.00

lung:0.00

bladder:-

kidney:0.33

pituitary:-

thyroid/parathyroid:0.14

adrenal gland:0.72

pancreas:-

breast:0.25

salivary:-

IDs

Refseq ID	NM_001012957
Gene ID	27185
Unigene ID	Hs.133183
Probe set ID	206090_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000162946
GTEx ID	ENSG00000162946

Orthologous Gene

Mouse[2]	NM_174853, NM_174854
Rat[1]	NM_175596, NM_174854

Chromosomal Region

1q42.2 [231,762,561 - 232,177,018]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0021846	cell proliferation in forebrain
GO:0021799	cerebral cortex radially oriented cell migration
GO:0000226	microtubule cytoskeleton organization
GO:0051560	mitochondrial calcium ion homeostasis
GO:0001764	neuron migration
GO:0002052	positive regulation of neuroblast proliferation
GO:0030177	positive regulation of Wnt receptor signaling pathway
GO:0008104	protein localization
GO:0010975	regulation of neuron projection development
GO:0090128	regulation of synapse maturation
GO:0031929	TOR signaling pathway
GO:0060070	Wnt receptor signaling pathway through beta-catenin

Cellular Component

GO:0030054	cell junction
GO:0005813	centrosome
GO:0005874	microtubule
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0045211	postsynaptic membrane

Molecular Function

GO:0005515

protein binding

disrupted in schizophrenia 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function