GLI family zinc finger 2

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Synonym

Zinc finger protein GLI2, THP2, THP, GLI2, Tax helper protein, GLI-Kruppel family member GLI2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:4.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:237.30 eye:5.90 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:121 bone:12.80 skin:28.80
GeneChip cerebrum:3.41 cerebellum:3.36 brain stem:3.37 corpus callosum/glia:3.33 pineal gland:- peripheral nerve:3.60 spine:3.47 retina:- eye:- artery/aorta:3.85 vein:4.43 lymphnode:3.43 peripheral blood:- spleen:3.36 thymus:3.46 bone marrow:3.34 adipose:3.69 bone:- skin:3.67
CAGE cerebrum:1.13 cerebellum:- brain stem:0.81 corpus callosum/glia:1.06 pineal gland:0 peripheral nerve:- spine:0.92 retina:- eye:- artery/aorta:1.65 vein:1.23 lymphnode:0.80 peripheral blood:- spleen:0.66 thymus:0.88 bone marrow:- adipose:0.14 bone:- skin:-
RNA-seq cerebrum:0.32 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.48 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.42 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:- prostate:45.10 ovary:- testis:34.60 heart:38.30 muscle:- esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:10.60        lung:44    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:18.60 salivary:-
GeneChip uterus:4.47 placenta:3.09 prostate:3.65 ovary:4.94 testis:3.85 heart:3.70 muscle:3.60 esophagus:3.65 stomach:3.94 intestine:3.64 colon:4 liver/hepato:3.26 lung:3.53 bladder:- kidney:3.36 pituitary:4.01 thyroid/parathyroid:3.47 adrenal gland:3.67 pancreas:3.30 breast:4.18 salivary:3.32
CAGE uterus:2.14 placenta:0.85 prostate:1.88 ovary:3.03 testis:1.63 heart:1.10 muscle:0.34 esophagus:1.48 stomach:- intestine:1.33 colon:1.26     liver/hepato:0.26    lung:1.15 bladder:1.58 kidney:0.67 pituitary:0.56 thyroid/parathyroid:0.53 adrenal gland:- pancreas:0 breast:0.55 salivary:0.36
RNA-seq uterus:- placenta:- prostate:0.99 ovary:2.63 testis:1.43 heart:0.05 muscle:0.21 esophagus:- stomach:- intestine:- colon:0.60     liver/hepato:0.02        lung:0.83    bladder:- kidney:0.31 pituitary:- thyroid/parathyroid:0.18 adrenal gland:0.62 pancreas:- breast:0.42 salivary:-

Gene Information

IDs

Refseq ID NM_005270
Gene ID 2736
Unigene ID Hs.111867
Probe set ID 207034_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000074047
GTEx ID ENSG00000074047

Orthologous Gene

Mouse[2]  NM_001081125
Rat[1]  NM_001107169

Chromosomal Region

2q14.2  [121,493,199  -  121,750,229]

Gene Family (Interpro ID)

IPR015880  Zinc finger, C2H2-like
IPR007087  Zinc finger, C2H2-type

Link to Pubmed  (Pubmed ID)

2832761
2850480
8150204
8350401
8378770
8812445
9557682
9731531
10074179
10564661
10806483
11160734
11238441
12165851
12435627
12477932
12917489
14581620
14691458
15175043
15994174
16192985
16327884
16434164
16553965
16651270
16953426
17569090
17638910
18006803
18264131
18319260
18794086
19015636
19432668
19453261
19584075
19593328
19937600
19996099
20081843
20099029
20146882
20201926
20301702
20379614
20420697
20487506
20488474
20634891
20660365
20685856
20712011
20932654
20939080
21095584
21204792
21454528
21695716
21801332
21862631
22040957
22395235
22496449
22535603
22747683
22859956
22967285
23178452
23208494
23304807
23326517
23356443
23408573
23493353
23762415
23792444
23890107
24418624

Gene Ontology  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0007411  axon guidance
GO:0048754  branching morphogenesis of a tube
GO:0008283  cell proliferation
GO:0071407  cellular response to organic cyclic substance
GO:0021696  cerebellar cortex morphogenesis
GO:0090103  cochlea morphogenesis
GO:0048589  developmental growth
GO:0042733  embryonic digit morphogenesis
GO:0048566  embryonic gut development
GO:0009913  epidermal cell differentiation
GO:0021508  floor plate formation
GO:0060322  head development
GO:0007507  heart development
GO:0030902  hindbrain development
GO:0007442  hindgut morphogenesis
GO:0001701  in utero embryonic development
GO:0001822  kidney development
GO:0030324  lung development
GO:0030879  mammary gland development
GO:0060603  mammary gland duct morphogenesis
GO:0032331  negative regulation of chondrocyte differentiation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0048666  neuron development
GO:0060032  notochord regression
GO:0042475  odontogenesis of dentine-containing tooth
GO:0002076  osteoblast development
GO:0001649  osteoblast differentiation
GO:0007389  pattern specification process
GO:0021983  pituitary gland development
GO:0045740  positive regulation of DNA replication
GO:0045666  positive regulation of neuron differentiation
GO:0033089  positive regulation of T cell differentiation in the thymus
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0060513  prostatic bud formation
GO:0009954  proximal/distal pattern formation
GO:0008589  regulation of smoothened signaling pathway
GO:0006355  regulation of transcription, DNA-dependent
GO:0009612  response to mechanical stimulus
GO:0001501  skeletal system development
GO:0007224  smoothened signaling pathway
GO:0060831  smoothened signaling pathway involved in dorsal/ventral neural tube patterning
GO:0021938  smoothened signaling pathway involved in regulation of granule cell precursor cell proliferation
GO:0021776  smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
GO:0021775  smoothened signaling pathway involved in ventral spinal cord interneuron specification
GO:0021513  spinal cord dorsal/ventral patterning
GO:0021965  spinal cord ventral commissure morphogenesis
GO:0006351  transcription, DNA-dependent
GO:0035295  tube development
GO:0007418  ventral midline development
GO:0021517  ventral spinal cord development

Cellular Component

GO:0005737  cytoplasm
GO:0016020  membrane
GO:0031512  motile primary cilium
GO:0016607  nuclear speck
GO:0005634  nucleus

Molecular Function

GO:0003682  chromatin binding
GO:0044212  DNA regulatory region binding
GO:0005515  protein binding
GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity
GO:0008270  zinc ion binding