glycosylphosphatidylinositol specific phospholipase D1

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Synonym

Glycoprotein phospholipase D, GPLD1, GPIPLDM, PIGPLD, GPIPLD, MGC22590, PI-G PLD, PIGPLD1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:40.30 cerebellum:100.80 brain stem:- corpus callosum/glia:58.30 pineal gland:296.70 peripheral nerve:61.30 spine:112.30 retina:237.30 eye:58.80 artery/aorta:119.90 vein:- lymphnode:101.10 peripheral blood:18.20 spleen:18.90 thymus:- bone marrow:- adipose:80.70 bone:- skin:24
GeneChip cerebrum:3.68 cerebellum:4.87 brain stem:3.67 corpus callosum/glia:3.33 pineal gland:- peripheral nerve:3.32 spine:3.54 retina:- eye:- artery/aorta:3.57 vein:3.18 lymphnode:3.15 peripheral blood:- spleen:3.22 thymus:5.49 bone marrow:3.68 adipose:3.61 bone:- skin:3.83
CAGE cerebrum:1.99 cerebellum:- brain stem:1.49 corpus callosum/glia:1.19 pineal gland:2.93 peripheral nerve:- spine:1.30 retina:- eye:- artery/aorta:1.68 vein:1.10 lymphnode:0.58 peripheral blood:- spleen:0.45 thymus:2.29 bone marrow:- adipose:1.16 bone:- skin:-
RNA-seq cerebrum:0.25 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.03 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.00 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:63.80 placenta:51 prostate:11.30 ovary:- testis:8.70 heart:76.60 muscle:120.50 esophagus:- stomach:21.20 intestine:32.40 colon:59.40     liver/hepato:10.60        lung:48.90    bladder:251.20 kidney:93.60 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:71.10 breast:- salivary:-
GeneChip uterus:3.31 placenta:2.97 prostate:3.61 ovary:3.11 testis:3.50 heart:3.08 muscle:3.42 esophagus:2.91 stomach:3.37 intestine:3.21 colon:3.38 liver/hepato:6.93 lung:2.99 bladder:- kidney:3.08 pituitary:3.76 thyroid/parathyroid:3.49 adrenal gland:2.87 pancreas:3.04 breast:3.99 salivary:3
CAGE uterus:1.02 placenta:0.16 prostate:1.14 ovary:0.42 testis:1.38 heart:0.73 muscle:0.24 esophagus:0.26 stomach:- intestine:0.33 colon:0.53     liver/hepato:3.76    lung:0.45 bladder:1.09 kidney:0.27 pituitary:1.54 thyroid/parathyroid:0.85 adrenal gland:- pancreas:1.21 breast:1.53 salivary:0
RNA-seq uterus:- placenta:- prostate:0.17 ovary:0.03 testis:0.02 heart:0.00 muscle:0 esophagus:- stomach:- intestine:- colon:0.00     liver/hepato:0.38        lung:0.08    bladder:- kidney:0 pituitary:- thyroid/parathyroid:0.43 adrenal gland:0.00 pancreas:- breast:0.15 salivary:-

Gene Information

IDs

Refseq ID NM_177483
Gene ID 2822
Unigene ID Hs.533291
Probe set ID 215554_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000112293
GTEx ID ENSG00000112293

Orthologous Gene

Mouse[1]  NM_008156
Rat[1]  NM_001100512

Chromosomal Region

6p22.3  [24,424,793  -  24,495,433]

Gene Family (Interpro ID)

IPR013517  FG-GAP
IPR013519  Integrin alpha beta-propellor

Link to Pubmed  (Pubmed ID)

1606959
1833386
2017684
2760042
7512501
10752311
11072085
11254757
11938765
11939716
11939719
11989719
12090469
12367767
12477932
12536633
14574404
14767861
15489334
15500911
15500962
15814706
15907827
16335952
16831865
17368745
17467053
17720976
17761367
17897319
17949898
18298948
18328347
18940312
19135435
19460752
20137110
20139978
20648472
20858461
21131602
22001757
22260953
22481092

Gene Ontology  (GO ID)

Biological Process

GO:0002042  cell migration involved in sprouting angiogenesis
GO:0071277  cellular response to calcium ion
GO:0071397  cellular response to cholesterol
GO:0032869  cellular response to insulin stimulus
GO:0071467  cellular response to pH
GO:0071401  cellular response to triglyceride
GO:0002062  chondrocyte differentiation
GO:0002430  complement receptor mediated signaling pathway
GO:0006507  GPI anchor release
GO:0008286  insulin receptor signaling pathway
GO:0008285  negative regulation of cell proliferation
GO:0010897  negative regulation of triglyceride catabolic process
GO:0001503  ossification
GO:0046470  phosphatidylcholine metabolic process
GO:0010694  positive regulation of alkaline phosphatase activity
GO:0043065  positive regulation of apoptosis
GO:0045919  positive regulation of cytolysis
GO:0010595  positive regulation of endothelial cell migration
GO:0010907  positive regulation of glucose metabolic process
GO:0010983  positive regulation of high-density lipoprotein particle clearance
GO:0051044  positive regulation of membrane protein ectodomain proteolysis
GO:0051047  positive regulation of secretion
GO:0010867  positive regulation of triglyceride biosynthetic process
GO:0009749  response to glucose stimulus
GO:0070633  transepithelial transport

Cellular Component

GO:0005737  cytoplasm
GO:0044444  cytoplasmic part
GO:0005615  extracellular space
GO:0005622  intracellular
GO:0043231  intracellular membrane-bounded organelle
GO:0005578  proteinaceous extracellular matrix

Molecular Function

GO:0004621  glycosylphosphatidylinositol phospholipase D activity
GO:0004630  phospholipase D activity
GO:0017080  sodium channel regulator activity