homeodomain interacting protein kinase 2

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Synonym

PRO0593, hHIPk2, homeodomain-interacting protein kinase 2, Homeodomain-interacting protein kinase 2, HIPK2, homeodomain interacting protein kinase 2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:221.60 cerebellum:37.80 brain stem:- corpus callosum/glia:175 pineal gland:296.70 peripheral nerve:122.70 spine:- retina:355.90 eye:164.60 artery/aorta:89.90 vein:- lymphnode:20.20 peripheral blood:- spleen:37.80 thymus:38.70 bone marrow:216.50 adipose:40.30 bone:51.20 skin:105.60
GeneChip cerebrum:8.03 cerebellum:6.88 brain stem:7.76 corpus callosum/glia:9.57 pineal gland:- peripheral nerve:6.04 spine:8.35 retina:- eye:- artery/aorta:6.41 vein:5.87 lymphnode:6.12 peripheral blood:- spleen:6.62 thymus:5.03 bone marrow:5.77 adipose:6.64 bone:- skin:5.71
CAGE cerebrum:5.28 cerebellum:- brain stem:5.71 corpus callosum/glia:6.52 pineal gland:5.00 peripheral nerve:- spine:5.52 retina:- eye:- artery/aorta:4.19 vein:4.04 lymphnode:4.12 peripheral blood:- spleen:4.51 thymus:3.31 bone marrow:- adipose:4.93 bone:- skin:-
RNA-seq cerebrum:2.04 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.87 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.88 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:45.60 placenta:51 prostate:123.90 ovary:37.30 testis:26 heart:114.90 muscle:60.30 esophagus:- stomach:63.70 intestine:- colon:84.80     liver/hepato:52.80        lung:73.30    bladder:125.60 kidney:83.20 pituitary:232 thyroid/parathyroid:163.70 adrenal gland:253.90 pancreas:222.30 breast:158 salivary:-
GeneChip uterus:5.50 placenta:5.71 prostate:6.32 ovary:6.02 testis:5.14 heart:7.33 muscle:6.34 esophagus:6.84 stomach:7.36 intestine:6.28 colon:6.34 liver/hepato:7.53 lung:6.69 bladder:- kidney:7.95 pituitary:6.42 thyroid/parathyroid:6.48 adrenal gland:7.10 pancreas:6.77 breast:6.36 salivary:6.98
CAGE uterus:3.65 placenta:3.28 prostate:3.98 ovary:3.73 testis:3.26 heart:4.79 muscle:4.96 esophagus:3.81 stomach:- intestine:3.98 colon:3.83     liver/hepato:5.23    lung:4.48 bladder:3.84 kidney:5.05 pituitary:4.44 thyroid/parathyroid:4.08 adrenal gland:- pancreas:3.82 breast:5.09 salivary:3.93
RNA-seq uterus:- placenta:- prostate:1.22 ovary:0.74 testis:1.48 heart:3.48 muscle:2.00 esophagus:- stomach:- intestine:- colon:2.05     liver/hepato:2.80        lung:3.03    bladder:- kidney:2.75 pituitary:- thyroid/parathyroid:3.03 adrenal gland:0.52 pancreas:- breast:3.38 salivary:-

Gene Information

IDs

Refseq ID NM_022740
Gene ID 28996
Unigene ID Hs.397465
Probe set ID 219028_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000064393
GTEx ID ENSG00000064393

Orthologous Gene

Mouse[18]  NM_001136065, NM_010433
Rat[1]  NM_001108622, NM_010433

Chromosomal Region

7q34  [139,246,316  -  139,477,577]

Gene Family (Interpro ID)

IPR000719  Protein kinase, catalytic domain
IPR011009  Protein kinase-like domain
IPR002290  Serine/threonine-protein kinase domain
IPR017442  Serine/threonine-protein kinase-like domain
IPR001245  Tyrosine-protein kinase, catalytic domain
IPR020635  Tyrosine-protein kinase, subgroup, catalytic domain

Link to Pubmed  (Pubmed ID)

8619474
9110174
9748262
9847074
10535925
10559189
11032752
11120354
11267674
11438542
11532197
11593421
11740489
11780126
11798164
11875057
11925430
12220523
12477932
12690205
12851404
12853948
12874272
12907596
14609633
14626429
14647468
14667819
14678985
14990717
15082531
15122315
15146197
15708980
15766567
15896780
15958389
16055500
16212962
16253240
16343438
16407227
16467083
16601678
16730941
16738336
16917507
17018294
17245128
17332358
17349959
17533375
17627287
17960875
18029348
18093972
18395248
18408760
18483253
18536714
18644116
18695000
18765672
18809579
18974774
18996371
19015637
19043406
19046997
19128456
19250734
19438900
19448668
19465479
19567674
19642869
19668373
19714248
19794125
19820693
19828042
19950553
20188669
20379614
20418953
20573984
20624637
20849851
20936779
20940704
20980392
21057547
21145359
21173028
21192925
21248071
21248371
21285352
21514416
21569099
21602882
21715331
21906983
21963094
21988832
22110707
22236966
22395153
22406746
22503103
22658722
22689412
23144866
23503458
23536002
23540226
23565059
23703384
23722549
23826318
23871434
24107646
24145406
24211575

Gene Ontology  (GO ID)

Biological Process

GO:0007628  adult walking behavior
GO:0009952  anterior/posterior pattern formation
GO:0071456  cellular response to hypoxia
GO:0042771  DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
GO:0006978  DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0048596  embryonic camera-type eye morphogenesis
GO:0060059  embryonic retina morphogenesis in camera-type eye
GO:0030218  erythrocyte differentiation
GO:0001654  eye development
GO:0060235  lens induction in camera-type eye
GO:0030514  negative regulation of BMP signaling pathway
GO:0043524  negative regulation of neuron apoptosis
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0030182  neuron differentiation
GO:0018105  peptidyl-serine phosphorylation
GO:0018107  peptidyl-threonine phosphorylation
GO:0030578  PML body organization
GO:0045766  positive regulation of angiogenesis
GO:0008284  positive regulation of cell proliferation
GO:0043388  positive regulation of DNA binding
GO:0046330  positive regulation of JNK cascade
GO:0032092  positive regulation of protein binding
GO:0051091  positive regulation of transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0030511  positive regulation of transforming growth factor beta receptor signaling pathway
GO:0006468  protein amino acid phosphorylation
GO:0051726  regulation of cell cycle
GO:0010842  retina layer formation
GO:0060395  SMAD protein signal transduction
GO:0007224  smoothened signaling pathway
GO:0007179  transforming growth factor beta receptor signaling pathway
GO:0019048  virus-host interaction
GO:0050882  voluntary musculoskeletal movement

Cellular Component

GO:0005813  centrosome
GO:0005737  cytoplasm
GO:0016604  nuclear body
GO:0031965  nuclear membrane
GO:0005634  nucleus
GO:0016605  PML body

Molecular Function

GO:0005524  ATP binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0046332  SMAD binding
GO:0003714  transcription corepressor activity
GO:0046790  virion binding