H2.0-like homeobox

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Synonym

H2.0-like homeo box 1 (Drosophila), HLX1, H2.0-like homeobox 1 (Drosophila), H2.0 (Drosophila)-like homeo box 1, HB24, Homeobox protein HLX1, Homeobox protein HB24

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:2.40 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:11.80 artery/aorta:30 vein:- lymphnode:- peripheral blood:- spleen:37.80 thymus:12.90 bone marrow:19.70 adipose:- bone:38.40 skin:4.80
GeneChip cerebrum:4.42 cerebellum:4.41 brain stem:4.47 corpus callosum/glia:4.51 pineal gland:- peripheral nerve:5.02 spine:4.51 retina:- eye:- artery/aorta:5.89 vein:5.52 lymphnode:5.38 peripheral blood:- spleen:5.62 thymus:4.62 bone marrow:7.36 adipose:5.94 bone:- skin:5.21
CAGE cerebrum:1.24 cerebellum:- brain stem:1.59 corpus callosum/glia:1.41 pineal gland:0.71 peripheral nerve:- spine:2.44 retina:- eye:- artery/aorta:2.32 vein:2.90 lymphnode:2.27 peripheral blood:- spleen:2.71 thymus:1.08 bone marrow:- adipose:3.66 bone:- skin:-
RNA-seq cerebrum:0.45 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.78 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.71 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:9.10 placenta:25.50 prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:64.80 colon:8.50     liver/hepato:10.60        lung:24.40    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:5.32 placenta:5.77 prostate:4.74 ovary:5.49 testis:4.29 heart:5.61 muscle:5.05 esophagus:5.03 stomach:5.13 intestine:5.47 colon:6.75 liver/hepato:6.28 lung:6.41 bladder:- kidney:4.76 pituitary:4.69 thyroid/parathyroid:5.18 adrenal gland:5.16 pancreas:5.04 breast:5.35 salivary:4.60
CAGE uterus:2.35 placenta:2.89 prostate:2.40 ovary:2.02 testis:1.51 heart:2.86 muscle:2.15 esophagus:2.55 stomach:- intestine:2.14 colon:3.06     liver/hepato:2.58    lung:3.13 bladder:2.77 kidney:1.51 pituitary:0.92 thyroid/parathyroid:1.81 adrenal gland:- pancreas:1.87 breast:3.24 salivary:1.15
RNA-seq uterus:- placenta:- prostate:2.15 ovary:1.60 testis:1.99 heart:0.96 muscle:2.04 esophagus:- stomach:- intestine:- colon:3.72     liver/hepato:1.30        lung:3.19    bladder:- kidney:0.85 pituitary:- thyroid/parathyroid:1.43 adrenal gland:2.59 pancreas:- breast:2.28 salivary:-

Gene Information

IDs

Refseq ID NM_021958
Gene ID 3142
Unigene ID Hs.74870
Probe set ID 214438_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000136630
GTEx ID ENSG00000136630

Orthologous Gene

Mouse[1]  NM_008250
Rat[1]  NM_001077674

Chromosomal Region

1q41  [221,051,699  -  221,059,124]

Gene Family (Interpro ID)

IPR001356  Homeobox
IPR009057  Homeodomain-like
IPR012287  Homeodomain-related

Link to Pubmed  (Pubmed ID)

1283323
1349016
1375114
1672660
1676597
1712647
7680402
7806220
8094082
8095486
9073066
9665637
12477932
14702039
16344560
16436665
16902145
17110450
17532041
18029348
18402755
19038437
19295429
19362357
19459883
20008130
20554918
21224470
21890473
22014209
22303482
22897850
22989111
23243425
23251661
23888188

Gene Ontology  (GO ID)

Biological Process

GO:0030154  cell differentiation
GO:0048557  embryonic digestive tract morphogenesis
GO:0048484  enteric nervous system development
GO:0001889  liver development
GO:0007275  multicellular organismal development
GO:0045629  negative regulation of T-helper 2 cell differentiation
GO:0008284  positive regulation of cell proliferation
GO:0046622  positive regulation of organ growth
GO:0045627  positive regulation of T-helper 1 cell differentiation
GO:0007519  skeletal muscle tissue development
GO:0006351  transcription, DNA-dependent

Cellular Component

GO:0005634  nucleus

Molecular Function

GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity