high-mobility group box 2

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Synonym

high-mobility group box 2, High mobility group protein B2, High mobility group protein 2, HMG-2, HMG2, HMGB2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:10.70 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:112.30 retina:118.60 eye:111.70 artery/aorta:60 vein:133.30 lymphnode:242.60 peripheral blood:72.90 spleen:56.70 thymus:206.10 bone marrow:98.40 adipose:- bone:89.60 skin:52.80
GeneChip cerebrum:6.17 cerebellum:5.18 brain stem:6.62 corpus callosum/glia:7.05 pineal gland:- peripheral nerve:7.38 spine:7.18 retina:- eye:- artery/aorta:7.83 vein:7.52 lymphnode:8.84 peripheral blood:- spleen:8.60 thymus:11.59 bone marrow:11.09 adipose:8.02 bone:- skin:8.42
CAGE cerebrum:3.48 cerebellum:- brain stem:3.60 corpus callosum/glia:3.54 pineal gland:4.08 peripheral nerve:- spine:4.05 retina:- eye:- artery/aorta:4.32 vein:5.11 lymphnode:4.84 peripheral blood:- spleen:4.67 thymus:6.46 bone marrow:- adipose:4.30 bone:- skin:-
RNA-seq cerebrum:3.75 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.74 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:5.02 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:72.90 placenta:29.10 prostate:11.30 ovary:223.60 testis:30.30 heart:178.80 muscle:- esophagus:- stomach:85 intestine:129.60 colon:33.90     liver/hepato:306.10        lung:88    bladder:- kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:26.70 breast:83.60 salivary:-
GeneChip uterus:8.57 placenta:7.60 prostate:8.20 ovary:8.74 testis:9.64 heart:7.88 muscle:7.16 esophagus:8.24 stomach:7.90 intestine:8.37 colon:8.81 liver/hepato:6.41 lung:8.08 bladder:- kidney:7.14 pituitary:6.22 thyroid/parathyroid:8.35 adrenal gland:6.46 pancreas:7.06 breast:7.97 salivary:6.69
CAGE uterus:4.34 placenta:4.11 prostate:4.38 ovary:4.59 testis:4.65 heart:4.36 muscle:4.87 esophagus:4.75 stomach:- intestine:4.34 colon:4.46     liver/hepato:2.90    lung:4.27 bladder:4.67 kidney:3.94 pituitary:3.21 thyroid/parathyroid:4.23 adrenal gland:- pancreas:3.06 breast:4.36 salivary:3.45
RNA-seq uterus:- placenta:- prostate:5.01 ovary:4.45 testis:5.51 heart:2.59 muscle:3.35 esophagus:- stomach:- intestine:- colon:5.03     liver/hepato:0.23        lung:4.73    bladder:- kidney:3.80 pituitary:- thyroid/parathyroid:4.65 adrenal gland:3.95 pancreas:- breast:3.13 salivary:-

Gene Information

IDs

Refseq ID NM_002129
Gene ID 3148
Unigene ID Hs.434953
Probe set ID 208808_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000164104
GTEx ID ENSG00000164104

Orthologous Gene

Mouse[6]  NM_008252
Rat[6]  NM_008252

Chromosomal Region

4q34.1  [174,252,846  -  174,256,276]

Gene Family (Interpro ID)

IPR000910  High mobility group, HMG1/HMG2
IPR000135  High mobility group, HMG1/HMG2, subgroup
IPR009071  High mobility group, superfamily

Link to Pubmed  (Pubmed ID)

978439
1475204
1551873
1754403
3697355
7720710
7797075
8226934
8339930
8824816
8889548
9600082
9636147
9671457
9722660
10490593
11099378
11748232
11909973
12062430
12477932
12517784
12524539
12555809
12925773
14729942
14739282
15005629
15489334
15504738
15833996
16341674
16344560
17008916
17406091
17964600
18029348
18239742
18850631
19139395
19223331
19236006
19322201
19369647
19505873
19738201
19811285
19965638
20036050
20851854
21139048
21209461
21319273
21832049
21890473
21890638
21906983
22242598
22345443
22505724
22644337
22863883
22939629
23000965
23143110
23255232
23455922
23828241
24457600
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0006288  base-excision repair, DNA ligation
GO:0060326  cell chemotaxis
GO:0006921  cell structure disassembly during apoptosis
GO:0071222  cellular response to lipopolysaccharide
GO:0006325  chromatin organization
GO:0006309  DNA fragmentation involved in apoptosis
GO:0051103  DNA ligation during DNA repair
GO:0006265  DNA topological change
GO:0008584  male gonad development
GO:0043066  negative regulation of apoptosis
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0006334  nucleosome assembly
GO:0048015  phosphoinositide-mediated signaling
GO:0050918  positive chemotaxis
GO:0043388  positive regulation of DNA binding
GO:0001938  positive regulation of endothelial cell proliferation
GO:0045648  positive regulation of erythrocyte differentiation
GO:0045654  positive regulation of megakaryocyte differentiation
GO:0032075  positive regulation of nuclease activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0006357  regulation of transcription from RNA polymerase II promoter
GO:0048545  response to steroid hormone stimulus
GO:0007289  spermatid nucleus differentiation
GO:0033151  V(D)J recombination

Cellular Component

GO:0000793  condensed chromosome
GO:0005737  cytoplasm
GO:0005615  extracellular space
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0043234  protein complex

Molecular Function

GO:0042056  chemoattractant activity
GO:0003684  damaged DNA binding
GO:0008301  DNA bending activity
GO:0003677  DNA binding
GO:0044212  DNA regulatory region binding
GO:0003690  double-stranded DNA binding
GO:0005515  protein binding
GO:0019904  protein domain specific binding
GO:0050786  RAGE receptor binding
GO:0003697  single-stranded DNA binding
GO:0003700  transcription factor activity