hepatocyte nuclear factor 4, alpha

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Synonym

hepatocyte nuclear factor 4, alpha, TCF, Transcription factor 14, NR2A21, Transcription factor HNF-4, HNF4, NR2A1, HNF4a9, Hepatocyte nuclear factor 4-alpha, HNF4a7, TCF14, HNF-4-alpha, FLJ39654, HNF4a8, HNF4A, MODY, MODY1

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:6.11 cerebellum:6.61 brain stem:6.04 corpus callosum/glia:6.07 pineal gland:- peripheral nerve:5.83 spine:5.82 retina:- eye:- artery/aorta:6.06 vein:6.45 lymphnode:5.83 peripheral blood:- spleen:5.82 thymus:5.99 bone marrow:6.27 adipose:6 bone:- skin:6.05
CAGE cerebrum:0.05 cerebellum:- brain stem:0 corpus callosum/glia:0.07 pineal gland:0 peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0 vein:0 lymphnode:0 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.00 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.00 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:3.60 prostate:- ovary:111.80 testis:- heart:- muscle:- esophagus:- stomach:63.70 intestine:64.80 colon:262.90     liver/hepato:200.60        lung:-    bladder:- kidney:135.20 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:6.08 placenta:5.83 prostate:5.78 ovary:6.10 testis:5.81 heart:6.14 muscle:6.24 esophagus:6.10 stomach:5.91 intestine:6.19 colon:6.24 liver/hepato:6.31 lung:6.02 bladder:- kidney:6.34 pituitary:5.92 thyroid/parathyroid:5.84 adrenal gland:5.98 pancreas:6.72 breast:5.99 salivary:6.17
CAGE uterus:0 placenta:0 prostate:0 ovary:0.26 testis:0.31 heart:0.03 muscle:0 esophagus:0.09 stomach:- intestine:4.83 colon:4.66     liver/hepato:4.55    lung:0.17 bladder:0 kidney:4.07 pituitary:0 thyroid/parathyroid:0 adrenal gland:- pancreas:3.69 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0 ovary:0.16 testis:0.21 heart:0 muscle:0 esophagus:- stomach:- intestine:- colon:0.80     liver/hepato:4.17        lung:0.00    bladder:- kidney:3.05 pituitary:- thyroid/parathyroid:0.00 adrenal gland:0 pancreas:- breast:0 salivary:-

IDs

Refseq ID NM_000457
Gene ID 3172
Unigene ID Hs.116462
Probe set ID 216889_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000101076
GTEx ID ENSG00000101076

Orthologous Gene

Mouse[4]  NM_008261
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

1899928
7568236
7615825
7651430
7926813
8622695
8945471
8964514
9048927
9115274
9243109
9267996
9294105
9313765
9371825
9434765
9449683
9717844
9792714
9792724
9795230
9812974
10085149
10330009
10551874
10594021
10609119
10652338
10737800
10786636
10882110
10995777
11229886
11549316
11590126
11717395
11733490
11741883
11772903
11780052
11811951
11818510
11834723
11916906
11994285
12036449
12050210
12083813
12086970
12089346
12101254
12110948
12133007
12203996
12205093
12220494
12235114
12413008
12477932
12504020
12519792
12522137
12544512
12551987
12627330
12631740
12669197
12697672
12701690
12740371
12829997
12855700
12911579
12944908
14551916
14563941
14654354
14702039
14722127
14988562
15047632
15047633
15123688
15194767
15281001
15322103
15337761
15342556
15358161
15470081
15504983
15519277
15520459
15547294
15561969
15604093
15616580
15651981
15660729
15728204
15734869
15735891
15735892
15744310
15752752
15793260
15794920
15796896
15826954
15830177
15831710
15919766
15928245
15933212
15983230
16007190
16051671
16186411
16223942
16338932
16351573
16488887
16502298
16523192
16562587
16584384
16644680
16712791
16731855
16731861
16752173
16771709
16804065
16838170
16873704
16882880
16883527
16893891
16929032
16936201
16946562
16955255
16978381
16980607
17007050
17022998
17052457
17259399
17264800
17291450
17300672
17317687
17327436
17343826
17344191
17353931
17393984
17403900
17407387
17464991
17466274
17563455
17574576
17576804
17601994
17636037
17764444
17785436
17805472
17827402
17827783
17876342
17885207
17891372
17894829
17895379
17920062
17923767
17932483
17958743
17965524
17991764
17992261
18028455
18029348
18056193
18162503
18163890
18184923
18199540
18234786
18268044
18305369
18305375
18332101
18346225
18356407
18391435
18395097
18426912
18498634
18513187
18513302
18552123
18561282
18602983
18654034
18660489
18666237
18728231
18765665
18805788
18811724
18829458
18844932
18988528
19048623
19060906
19115260
19147806
19154258
19179483
19188435
19228875
19228884
19302415
19336534
19353766
19389810
19406499
19435525
19454287
19467232
19549071
19563409
19575803
19578796
19651776
19740748
19748811
19761587
19805548
19846556
19913121
19915572
19924231
19934400
19948975
19966299
20003313
20079163
20086032
20158877
20164212
20167659
20211142
20301549
20308432
20361036
20371703
20375098
20379614
20384434
20463007
20516075
20546279
20558840
20576917
20622021
20628086
20670916
20682687
20684663
20686565
20705777
20714348
20735474
20863361
20871093
20878384
20926756
20931292
20976847
21047794
21062274
21062980
21292004
21300955
21352552
21384409
21442235
21493011
21494118
21618351
21633728
21646355
21683639
21708125
21725089
21733563
21744425
21760481
21799848
21814221
21831733
21852396
21874001
21922456
21983932
21988832
22009745
22060211
22068426
22140441
22153071
22155889
22158537
22197810
22240483
22282358
22308320
22333269
22357705
22383578
22432108
22505616
22628013
22791717
22802087
22902540
22914433
22939635
22952853
22960426
23038264
23052196
23108025
23128233
23268925
23292115
23307400
23348805
23354620
23628799
23652628
23775631
23803251
23874642
23878349
24059685
24097068
24713057

Gene Ontology  (GO ID)

Biological Process

GO:0007596  blood coagulation
GO:0031018  endocrine pancreas development
GO:0010467  gene expression
GO:0042593  glucose homeostasis
GO:0055088  lipid homeostasis
GO:0006629  lipid metabolic process
GO:0030308  negative regulation of cell growth
GO:0008285  negative regulation of cell proliferation
GO:0006591  ornithine metabolic process
GO:0055091  phospholipid homeostasis
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0010470  regulation of gastrulation
GO:0060398  regulation of growth hormone receptor signaling pathway
GO:0050796  regulation of insulin secretion
GO:0019216  regulation of lipid metabolic process
GO:0006357  regulation of transcription from RNA polymerase II promoter
GO:0009749  response to glucose stimulus
GO:0007548  sex differentiation
GO:0060395  SMAD protein signal transduction
GO:0006367  transcription initiation from RNA polymerase II promoter
GO:0070328  triglyceride homeostasis
GO:0006805  xenobiotic metabolic process

Cellular Component

GO:0005737  cytoplasm
GO:0005654  nucleoplasm
GO:0005634  nucleus

Molecular Function

GO:0003677  DNA binding
GO:0044212  DNA regulatory region binding
GO:0005504  fatty acid binding
GO:0004879  ligand-dependent nuclear receptor activity
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0005102  receptor binding
GO:0003705  RNA polymerase II transcription factor activity, enhancer binding
GO:0043565  sequence-specific DNA binding
GO:0003707  steroid hormone receptor activity
GO:0003700  transcription factor activity
GO:0008270  zinc ion binding