v-Ha-ras Harvey rat sarcoma viral oncogene homolog

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Synonym

c-bas/has, GTPase HRas precursor, H-Ras-1, N-ras, p21ras, c-H-ras, RASH1, Transforming protein p21, K-ras, HRAS, v-Ha-ras Harvey rat sarcoma viral oncogene homolog, HRAS1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:7.19 cerebellum:6.94 brain stem:7.33 corpus callosum/glia:6.71 pineal gland:- peripheral nerve:7.06 spine:6.86 retina:- eye:- artery/aorta:6.60 vein:6.40 lymphnode:6.57 peripheral blood:- spleen:6.28 thymus:6.05 bone marrow:5.71 adipose:6.57 bone:- skin:7.45
CAGE cerebrum:3.38 cerebellum:- brain stem:3.18 corpus callosum/glia:2.93 pineal gland:2.72 peripheral nerve:- spine:3.11 retina:- eye:- artery/aorta:2.79 vein:2.83 lymphnode:2.88 peripheral blood:- spleen:2.52 thymus:2.47 bone marrow:- adipose:2.66 bone:- skin:-
RNA-seq cerebrum:0.34 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.06 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.04 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:6.01 placenta:6.24 prostate:6.45 ovary:6.05 testis:6.06 heart:6.49 muscle:6.87 esophagus:7.79 stomach:6.09 intestine:6.33 colon:6.08 liver/hepato:5.96 lung:6.40 bladder:- kidney:6.33 pituitary:6.59 thyroid/parathyroid:6.14 adrenal gland:6.23 pancreas:5.96 breast:6.97 salivary:6.20
CAGE uterus:2.76 placenta:2.90 prostate:3.03 ovary:2.46 testis:2.69 heart:3.50 muscle:3.50 esophagus:3.56 stomach:- intestine:2.35 colon:2.63     liver/hepato:2.08    lung:2.90 bladder:3.11 kidney:2.84 pituitary:2.49 thyroid/parathyroid:2.77 adrenal gland:- pancreas:2.81 breast:3.54 salivary:2.93
RNA-seq uterus:- placenta:- prostate:0.00 ovary:0.38 testis:0.39 heart:0.26 muscle:0.00 esophagus:- stomach:- intestine:- colon:0.12     liver/hepato:0.39        lung:0.00    bladder:- kidney:0.00 pituitary:- thyroid/parathyroid:0.19 adrenal gland:0.16 pancreas:- breast:1.05 salivary:-

Gene Information

IDs

Refseq ID NM_001130442
Gene ID 3265
Unigene ID -
Probe set ID 212983_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000174775
GTEx ID ENSG00000174775

Orthologous Gene

Mouse[6]  NM_001130443, NM_001130444, NM_008284
Rat[4]  NM_001098241, NM_001130441, NM_008284

Chromosomal Region

11p15.5  [532,242  -  537,287]

Gene Family (Interpro ID)

IPR013753  Ras
IPR001806  Ras GTPase
IPR020849  Ras small GTPase
IPR003579  Ras small GTPase, Rab type
IPR005225  Small GTP-binding protein
IPR020851  Small GTPase
IPR003578  Small GTPase, Rho type

Link to Pubmed  (Pubmed ID)

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Gene Ontology  (GO ID)

Biological Process

GO:0030036  actin cytoskeleton organization
GO:0000186  activation of MAPKK activity
GO:0007411  axon guidance
GO:0007596  blood coagulation
GO:0007050  cell cycle arrest
GO:0008283  cell proliferation
GO:0007166  cell surface receptor linked signal transduction
GO:0006935  chemotaxis
GO:0006897  endocytosis
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0006917  induction of apoptosis
GO:0045087  innate immune response
GO:0008286  insulin receptor signaling pathway
GO:0050900  leukocyte migration
GO:0000165  MAPKKK cascade
GO:0007093  mitotic cell cycle checkpoint
GO:0008285  negative regulation of cell proliferation
GO:0010629  negative regulation of gene expression
GO:0043524  negative regulation of neuron apoptosis
GO:0034259  negative regulation of Rho GTPase activity
GO:0048011  nerve growth factor receptor signaling pathway
GO:0009887  organ morphogenesis
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0045740  positive regulation of DNA replication
GO:0050679  positive regulation of epithelial cell proliferation
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0046330  positive regulation of JNK cascade
GO:0043406  positive regulation of MAP kinase activity
GO:0043410  positive regulation of MAPKKK cascade
GO:0001934  positive regulation of protein amino acid phosphorylation
GO:0032855  positive regulation of Rac GTPase activity
GO:0035022  positive regulation of Rac protein signal transduction
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0051291  protein heterooligomerization
GO:0007265  Ras protein signal transduction
GO:0048169  regulation of long-term neuronal synaptic plasticity
GO:0032228  regulation of synaptic transmission, GABAergic
GO:0007165  signal transduction
GO:0007264  small GTPase mediated signal transduction
GO:0035176  social behavior
GO:0051146  striated muscle cell differentiation
GO:0007268  synaptic transmission
GO:0008542  visual learning

Cellular Component

GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0005794  Golgi apparatus
GO:0000139  Golgi membrane
GO:0005634  nucleus
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane

Molecular Function

GO:0005525  GTP binding
GO:0003924  GTPase activity
GO:0005515  protein binding
GO:0008022  protein C-terminus binding