hairy and enhancer of split 1, (Drosophila)

 jump to detail

Synonym

HRY, HES-1, Hairy and enhancer of split 1, Hes1, hairy homolog (Drosophila), Transcription factor HES-1, Hairy homolog, hairy and enhancer of split 1, (Drosophila), HHL, Hairy-like, FLJ20408, HES1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:20.10 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:61.30 spine:224.60 retina:237.30 eye:223.30 artery/aorta:30 vein:133.30 lymphnode:10.10 peripheral blood:36.40 spleen:18.90 thymus:12.90 bone marrow:- adipose:- bone:12.80 skin:19.20
GeneChip cerebrum:6.64 cerebellum:6.36 brain stem:6.44 corpus callosum/glia:7.31 pineal gland:- peripheral nerve:8.33 spine:7.80 retina:- eye:- artery/aorta:8.74 vein:9.44 lymphnode:8.27 peripheral blood:- spleen:8.68 thymus:7 bone marrow:6.58 adipose:8.46 bone:- skin:9.49
CAGE cerebrum:3.34 cerebellum:- brain stem:3.03 corpus callosum/glia:3.99 pineal gland:2.62 peripheral nerve:- spine:3.75 retina:- eye:- artery/aorta:4.90 vein:3.57 lymphnode:3.80 peripheral blood:- spleen:3.68 thymus:2.19 bone marrow:- adipose:4.77 bone:- skin:-
RNA-seq cerebrum:2.26 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.71 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.61 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:69.20 prostate:112.60 ovary:- testis:17.30 heart:25.50 muscle:20.10 esophagus:- stomach:21.20 intestine:- colon:-     liver/hepato:1615        lung:48.90    bladder:- kidney:52 pituitary:232 thyroid/parathyroid:- adrenal gland:- pancreas:97.80 breast:27.90 salivary:-
GeneChip uterus:8.32 placenta:9.10 prostate:9.85 ovary:8.16 testis:7.19 heart:8.63 muscle:7.49 esophagus:10.04 stomach:9.01 intestine:8.65 colon:9.42 liver/hepato:8.48 lung:9.57 bladder:- kidney:10.42 pituitary:7.93 thyroid/parathyroid:10.29 adrenal gland:9.16 pancreas:8.02 breast:10.13 salivary:8.90
CAGE uterus:4.60 placenta:4.38 prostate:4.92 ovary:4.07 testis:3.89 heart:3.49 muscle:4.70 esophagus:5.16 stomach:- intestine:3.83 colon:4.19     liver/hepato:4.44    lung:4.65 bladder:4.50 kidney:4.27 pituitary:3.26 thyroid/parathyroid:4.81 adrenal gland:- pancreas:4.23 breast:4.30 salivary:4.77
RNA-seq uterus:- placenta:- prostate:6.48 ovary:4.75 testis:3.95 heart:2.16 muscle:3.25 esophagus:- stomach:- intestine:- colon:3.70     liver/hepato:3.77        lung:5.61    bladder:- kidney:4.88 pituitary:- thyroid/parathyroid:4.79 adrenal gland:4.51 pancreas:- breast:4.29 salivary:-

Gene Information

IDs

Refseq ID NM_005524
Gene ID 3280
Unigene ID Hs.250666
Probe set ID 203394_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000114315
GTEx ID ENSG00000114315

Orthologous Gene

Mouse[1]  NM_008235
Rat[1]  NM_008235

Chromosomal Region

3q29  [193,853,934  -  193,856,521]

Gene Family (Interpro ID)

IPR003650  Orange
IPR018352  Orange subgroup

Link to Pubmed  (Pubmed ID)

7906273
8020957
8687460
9389649
9745030
9874198
10851137
11238932
11486045
11748221
11756408
12032823
12065598
12406868
12477932
12535671
12972610
14702039
14722248
15156153
15467735
15492808
15536134
15546612
15563463
16160079
16195230
16214363
16253247
16322473
16365048
16894395
17072841
17301032
17388915
17611704
17681138
17822320
18274550
18491256
18524252
18550849
18599525
18611861
18719287
18821565
18976975
19039095
19058789
19116245
19118200
19321451
19322201
19322650
19453261
19603167
19682396
19724860
19808903
19861684
19880519
19891787
19935883
20022559
20091184
20515776
20668890
20816878
20832754
21103979
21106062
21125297
21139048
21169257
21224467
21238798
21495212
21866461
21890473
21900206
21984123
21988832
22036964
22333607
22411914
22705236
22846929
22871495
23037857
23235341
23379739
23423517
23900217
24342613
24346283
24486648

Gene Ontology  (GO ID)

Biological Process

GO:0021984  adenohypophysis development
GO:0048844  artery morphogenesis
GO:0042668  auditory receptor cell fate determination
GO:0007155  cell adhesion
GO:0048469  cell maturation
GO:0016477  cell migration
GO:0048667  cell morphogenesis involved in neuron differentiation
GO:0090102  cochlea development
GO:0003143  embryonic heart tube morphogenesis
GO:0031018  endocrine pancreas development
GO:0021575  hindbrain morphogenesis
GO:0060716  labyrinthine layer blood vessel development
GO:0046331  lateral inhibition
GO:0001889  liver development
GO:0030324  lung development
GO:0030901  midbrain development
GO:0021555  midbrain-hindbrain boundary morphogenesis
GO:0045608  negative regulation of auditory receptor cell differentiation
GO:0060253  negative regulation of glial cell proliferation
GO:0048715  negative regulation of oligodendrocyte differentiation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0007399  nervous system development
GO:0007219  Notch signaling pathway
GO:0021557  oculomotor nerve development
GO:0003151  outflow tract morphogenesis
GO:0060037  pharyngeal system development
GO:0048711  positive regulation of astrocyte differentiation
GO:0030513  positive regulation of BMP signaling pathway
GO:0008284  positive regulation of cell proliferation
GO:0043388  positive regulation of DNA binding
GO:0046427  positive regulation of JAK-STAT cascade
GO:0045977  positive regulation of mitotic cell cycle, embryonic
GO:0045747  positive regulation of Notch signaling pathway
GO:0042102  positive regulation of T cell proliferation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0042517  positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0006461  protein complex assembly
GO:0021861  radial glial cell differentiation in the forebrain
GO:0045598  regulation of fat cell differentiation
GO:0003266  regulation of second heart field cardioblast proliferation
GO:0060164  regulation of timing of neuron differentiation
GO:0007224  smoothened signaling pathway
GO:0035019  somatic stem cell maintenance
GO:0007262  STAT protein nuclear translocation
GO:0021537  telencephalon development
GO:0048538  thymus development
GO:0021558  trochlear nerve development
GO:0060675  ureteric bud morphogenesis
GO:0003281  ventricular septum development
GO:0060412  ventricular septum morphogenesis

Cellular Component

GO:0005737  cytoplasm
GO:0005654  nucleoplasm
GO:0005634  nucleus

Molecular Function

GO:0003677  DNA binding
GO:0042826  histone deacetylase binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding