5-hydroxytryptamine (serotonin) receptor 2B

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Synonym

5-hydroxytryptamine (serotonin) receptor 2B, 5-HT-2B, 5-HT2B, 5-HT(2B), Serotonin receptor 2B, 5-hydroxytryptamine 2B receptor, HTR2B

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:2.40 cerebellum:- brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:60 vein:- lymphnode:- peripheral blood:18.20 spleen:- thymus:- bone marrow:- adipose:- bone:12.80 skin:19.20
GeneChip cerebrum:2.97 cerebellum:2.82 brain stem:3.11 corpus callosum/glia:2.90 pineal gland:- peripheral nerve:2.94 spine:2.90 retina:- eye:- artery/aorta:3.40 vein:4.38 lymphnode:3.53 peripheral blood:- spleen:2.95 thymus:2.89 bone marrow:3.05 adipose:3.43 bone:- skin:3.20
CAGE cerebrum:0.09 cerebellum:- brain stem:0.37 corpus callosum/glia:0.13 pineal gland:0.36 peripheral nerve:- spine:0.13 retina:- eye:- artery/aorta:1.10 vein:0.70 lymphnode:0.09 peripheral blood:- spleen:0.32 thymus:0.86 bone marrow:- adipose:1.12 bone:- skin:-
RNA-seq cerebrum:0.25 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.11 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.25 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:36.50 placenta:- prostate:11.30 ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:32.40 colon:-     liver/hepato:-        lung:-    bladder:- kidney:41.60 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:5.95 placenta:3.67 prostate:3.04 ovary:3.70 testis:2.84 heart:3.54 muscle:3.11 esophagus:3.15 stomach:3.61 intestine:3.84 colon:3.36 liver/hepato:3.35 lung:3.10 bladder:- kidney:3.40 pituitary:3.02 thyroid/parathyroid:3.58 adrenal gland:5.75 pancreas:3.02 breast:3.36 salivary:2.87
CAGE uterus:2.60 placenta:2.99 prostate:1.09 ovary:1.54 testis:1.27 heart:1.46 muscle:0.09 esophagus:1.81 stomach:- intestine:2.03 colon:1.31     liver/hepato:0.90    lung:0.83 bladder:1.68 kidney:1.73 pituitary:0 thyroid/parathyroid:1.89 adrenal gland:- pancreas:0 breast:2.02 salivary:0
RNA-seq uterus:- placenta:- prostate:1.16 ovary:1.18 testis:1.10 heart:0.76 muscle:0.11 esophagus:- stomach:- intestine:- colon:2.34     liver/hepato:0.86        lung:0.29    bladder:- kidney:1.36 pituitary:- thyroid/parathyroid:0.93 adrenal gland:1.90 pancreas:- breast:1.28 salivary:-

Gene Information

IDs

Refseq ID NM_000867
Gene ID 3357
Unigene ID Hs.421649
Probe set ID 206638_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000135914
GTEx ID ENSG00000135914

Orthologous Gene

Mouse[1]  NM_008311
Rat [0]  

Chromosomal Region

2q37.1  [231,972,944  -  231,989,832]

Gene Family (Interpro ID)

IPR000482  5-Hydroxytryptamine 2B receptor
IPR002231  5-Hydroxytryptamine receptor
IPR000276  7TM GPCR, rhodopsin-like
IPR017452  GPCR, rhodopsin-like superfamily

Link to Pubmed  (Pubmed ID)

7582481
7599919
7926008
8078486
8143856
8621713
8786115
8882600
9186750
10722792
10734074
11150294
11859080
11877320
11916537
12477932
12761501
12767050
12970106
15123239
15489334
15608559
15625277
15815621
15862800
15925089
16517693
16754659
17609583
18079067
18240029
18566482
18703043
19023134
19057895
19086053
19095219
19156168
19307114
19308295
19455600
19874574
19913121
20346360
20564397
20628086
20846463
21179162
21836641
22493371
22889411
22917605
23355731
23400010
23519215
24089568
24174497

Gene Ontology  (GO ID)

Biological Process

GO:0007205  activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway
GO:0070588  calcium ion transmembrane transport
GO:0019722  calcium-mediated signaling
GO:0003300  cardiac muscle hypertrophy
GO:0071277  cellular response to calcium ion
GO:0071502  cellular response to temperature stimulus
GO:0006182  cGMP biosynthetic process
GO:0048598  embryonic morphogenesis
GO:0070371  ERK1 and ERK2 cascade
GO:0002031  G-protein coupled receptor internalization
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0003007  heart morphogenesis
GO:0014827  intestine smooth muscle contraction
GO:0043066  negative regulation of apoptosis
GO:0010507  negative regulation of autophagy
GO:0060548  negative regulation of cell death
GO:0014033  neural crest cell differentiation
GO:0001755  neural crest cell migration
GO:0006661  phosphatidylinositol biosynthetic process
GO:0014065  phosphoinositide 3-kinase cascade
GO:0016310  phosphorylation
GO:0051781  positive regulation of cell division
GO:0008284  positive regulation of cell proliferation
GO:0001819  positive regulation of cytokine production
GO:0050715  positive regulation of cytokine secretion
GO:0001938  positive regulation of endothelial cell proliferation
GO:0043123  positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0043406  positive regulation of MAP kinase activity
GO:0051000  positive regulation of nitric-oxide synthase activity
GO:0070528  protein kinase C signaling cascade
GO:0050795  regulation of behavior
GO:0051209  release of sequestered calcium ion into cytosol
GO:0042493  response to drug
GO:0007210  serotonin receptor signaling pathway
GO:0042310  vasoconstriction

Cellular Component

GO:0005737  cytoplasm
GO:0005887  integral to plasma membrane
GO:0005886  plasma membrane

Molecular Function

GO:0005262  calcium channel activity
GO:0008144  drug binding
GO:0001965  G-protein alpha-subunit binding
GO:0004435  phosphoinositide phospholipase C activity
GO:0005099  Ras GTPase activator activity
GO:0051378  serotonin binding
GO:0004993  serotonin receptor activity