insulin-degrading enzyme

Synonym

Insulysin, Insulin protease, IDE, Insulinase, insulin-degrading enzyme, insulin-degrading enzyme (IDE), FLJ35968, Insulin-degrading enzyme, INSULYSIN

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:20.10

cerebellum:-

brain stem:-

corpus callosum/glia:87.50

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:76.40

artery/aorta:60

vein:-

lymphnode:111.20

peripheral blood:36.40

spleen:-

thymus:25.80

bone marrow:19.70

adipose:-

bone:25.60

skin:100.80

GeneChip

cerebrum:5.74

cerebellum:5.76

brain stem:5.75

corpus callosum/glia:5.78

pineal gland:-

peripheral nerve:5.97

spine:5.91

retina:-

eye:-

artery/aorta:6.52

vein:6.52

lymphnode:6.49

peripheral blood:-

spleen:6.19

thymus:6.99

bone marrow:6.06

adipose:6.43

bone:-

skin:7.83

CAGE

cerebrum:3.04

cerebellum:-

brain stem:3.24

corpus callosum/glia:3.01

pineal gland:4.28

peripheral nerve:-

spine:3.34

retina:-

eye:-

artery/aorta:3.19

vein:3.26

lymphnode:3.34

peripheral blood:-

spleen:3.35

thymus:3.48

bone marrow:-

adipose:3.41

bone:-

skin:-

RNA-seq

cerebrum:1.92

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:2.08

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.73

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:173.20

placenta:36.40

prostate:45.10

ovary:74.50

testis:173.10

heart:89.40

muscle:40.20

esophagus:-

stomach:-

intestine:-

colon:59.40

liver/hepato:31.70

lung:78.20

bladder:-

kidney:72.80

pituitary:116

thyroid/parathyroid:-

adrenal gland:50.80

pancreas:26.70

breast:46.50

salivary:-

GeneChip

uterus:6.55

placenta:5.74

prostate:7.14

ovary:6.42

testis:7.33

heart:6.98

muscle:7.98

esophagus:6.86

stomach:6.70

intestine:6.65

colon:6.02

liver/hepato:6.57

lung:6.35

bladder:-

kidney:6.14

pituitary:5.75

thyroid/parathyroid:6.76

adrenal gland:7.01

pancreas:6.86

breast:7.05

salivary:6.33

CAGE

uterus:3.42

placenta:3.23

prostate:3.40

ovary:3.16

testis:4.15

heart:3.74

muscle:4.20

esophagus:3.63

stomach:-

intestine:3.41

colon:3.28

liver/hepato:3.91

lung:3.27

bladder:3.52

kidney:3.58

pituitary:3.39

thyroid/parathyroid:3.41

adrenal gland:-

pancreas:3.65

breast:4.05

salivary:2.93

RNA-seq

uterus:-

placenta:-

prostate:2.75

ovary:2.76

testis:2.76

heart:3.43

muscle:4.56

esophagus:-

stomach:-

intestine:-

colon:2.38

liver/hepato:2.52

lung:1.92

bladder:-

kidney:2.61

pituitary:-

thyroid/parathyroid:3.46

adrenal gland:2.46

pancreas:-

breast:2.76

salivary:-

IDs

Refseq ID	NM_004969
Gene ID	3416
Unigene ID	Hs.500546
Probe set ID	203327_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000119912
GTEx ID	ENSG00000119912

Orthologous Gene

Mouse[4]	NM_031156
Rat [0]

Chromosomal Region

10q23.33 [94,211,441 - 94,333,833]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0050435	beta-amyloid metabolic process
GO:0010815	bradykinin catabolic process
GO:0008340	determination of adult lifespan
GO:0042447	hormone catabolic process
GO:0008286	insulin receptor signaling pathway
GO:0045861	negative regulation of proteolysis
GO:0032461	positive regulation of protein oligomerization
GO:0051291	protein heterooligomerization
GO:0051260	protein homooligomerization
GO:0051289	protein homotetramerization
GO:0006508	proteolysis
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:0010992	ubiquitin homeostasis
GO:0019048	virus-host interaction

Cellular Component

GO:0009986	cell surface
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0031597	cytosolic proteasome complex
GO:0005615	extracellular space
GO:0005739	mitochondrion
GO:0005634	nucleus
GO:0005782	peroxisomal matrix
GO:0005777	peroxisome
GO:0005886	plasma membrane

Molecular Function

GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0001540	beta-amyloid binding
GO:0031626	beta-endorphin binding
GO:0001948	glycoprotein binding
GO:0043559	insulin binding
GO:0004222	metalloendopeptidase activity
GO:0042277	peptide binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0005102	receptor binding
GO:0043130	ubiquitin binding
GO:0008270	zinc ion binding

insulin-degrading enzyme

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function