insulin-like growth factor 1 receptor

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Synonym

insulin-like growth factor 1 receptor, CD221 antigen, IGFIR, IGF1R, MGC142170, IGF-I receptor, JTK13, MGC142172, Insulin-like growth factor 1 receptor precursor, Insulin-like growth factor I receptor, CD221

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:23.50 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:7.21 cerebellum:7.08 brain stem:7.06 corpus callosum/glia:7.33 pineal gland:- peripheral nerve:7.04 spine:7.21 retina:- eye:- artery/aorta:7.72 vein:7.05 lymphnode:6.53 peripheral blood:- spleen:7.17 thymus:6.83 bone marrow:6.89 adipose:6.41 bone:- skin:7.06
CAGE cerebrum:3.12 cerebellum:- brain stem:3.02 corpus callosum/glia:3.19 pineal gland:3.77 peripheral nerve:- spine:3.07 retina:- eye:- artery/aorta:3.90 vein:2.54 lymphnode:2.61 peripheral blood:- spleen:2.60 thymus:2.86 bone marrow:- adipose:2.79 bone:- skin:-
RNA-seq cerebrum:2.53 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.76 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:3.02 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:10.90 prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:10.60        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:7.64 placenta:7.74 prostate:9.13 ovary:8.67 testis:6.98 heart:7.28 muscle:5.83 esophagus:6.98 stomach:7.47 intestine:6.81 colon:7.30 liver/hepato:4.90 lung:7.73 bladder:- kidney:8.59 pituitary:7.30 thyroid/parathyroid:8.19 adrenal gland:7.96 pancreas:7.75 breast:8.11 salivary:7.41
CAGE uterus:3.45 placenta:3.45 prostate:3.42 ovary:3.06 testis:3.33 heart:3.01 muscle:2.69 esophagus:2.98 stomach:- intestine:2.64 colon:3.09     liver/hepato:0.84    lung:3.08 bladder:3.10 kidney:3.01 pituitary:3.17 thyroid/parathyroid:3.31 adrenal gland:- pancreas:3.40 breast:2.74 salivary:2.93
RNA-seq uterus:- placenta:- prostate:3.35 ovary:3.31 testis:3.09 heart:2.42 muscle:2.07 esophagus:- stomach:- intestine:- colon:3.02     liver/hepato:0.61        lung:3.35    bladder:- kidney:3.15 pituitary:- thyroid/parathyroid:4.21 adrenal gland:2.49 pancreas:- breast:2.80 salivary:-

IDs

Refseq ID NM_000875
Gene ID 3480
Unigene ID Hs.643120
Probe set ID 203628_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000140443
GTEx ID ENSG00000140443

Orthologous Gene

Mouse[1]  NM_010513
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

1316909
1711844
1846292
1850606
1851182
1852007
2877871
2948220
3003744
3107886
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20154720
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24039995
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24065146
24127040
24130778
24135282
24219294
24222252
24285539
24307738

Gene Ontology  (GO ID)

Biological Process

GO:0007409  axonogenesis
GO:0007420  brain development
GO:0030010  establishment of cell polarity
GO:0031017  exocrine pancreas development
GO:0006955  immune response
GO:0051389  inactivation of MAPKK activity
GO:0008286  insulin receptor signaling pathway
GO:0048009  insulin-like growth factor receptor signaling pathway
GO:0030238  male sex determination
GO:0030879  mammary gland development
GO:0043066  negative regulation of apoptosis
GO:0051898  negative regulation of protein kinase B signaling cascade
GO:0014065  phosphoinositide 3-kinase cascade
GO:0048015  phosphoinositide-mediated signaling
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0032467  positive regulation of cytokinesis
GO:0045740  positive regulation of DNA replication
GO:0043410  positive regulation of MAPKKK cascade
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0090031  positive regulation of steroid hormone biosynthetic process
GO:0060740  prostate gland epithelium morphogenesis
GO:0046777  protein amino acid autophosphorylation
GO:0051291  protein heterooligomerization
GO:0051262  protein tetramerization
GO:0046328  regulation of JNK cascade
GO:0033197  response to vitamin E
GO:0007165  signal transduction

Cellular Component

GO:0005901  caveola
GO:0005887  integral to plasma membrane
GO:0043231  intracellular membrane-bounded organelle
GO:0016020  membrane
GO:0043005  neuron projection
GO:0005886  plasma membrane

Molecular Function

GO:0005524  ATP binding
GO:0001965  G-protein alpha-subunit binding
GO:0042802  identical protein binding
GO:0043559  insulin binding
GO:0005158  insulin receptor binding
GO:0043560  insulin receptor substrate binding
GO:0005520  insulin-like growth factor binding
GO:0031994  insulin-like growth factor I binding
GO:0005010  insulin-like growth factor receptor activity
GO:0043548  phosphoinositide 3-kinase binding
GO:0005515  protein binding
GO:0004713  protein tyrosine kinase activity