recombination signal binding protein for immunoglobulin kappa J region

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Synonym

Recombining binding protein suppressor of hairless, RBP-JK, KBF2, CBF-1, NY-REN-30 antigen, J kappa-recombination signal-binding protein, RBP-J, IGKJRB1, IGKJRB, RBPJK, CBF1, RBPSUH, csl, MGC61669, RBP-J kappa

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:78.20 cerebellum:113.30 brain stem:- corpus callosum/glia:58.30 pineal gland:- peripheral nerve:61.30 spine:- retina:- eye:58.80 artery/aorta:- vein:- lymphnode:20.20 peripheral blood:54.70 spleen:37.80 thymus:116 bone marrow:98.40 adipose:40.30 bone:12.80 skin:91.20
GeneChip cerebrum:9.07 cerebellum:8.72 brain stem:9.06 corpus callosum/glia:9.80 pineal gland:- peripheral nerve:8.93 spine:9.13 retina:- eye:- artery/aorta:9.15 vein:9.09 lymphnode:8.97 peripheral blood:- spleen:8.81 thymus:8.64 bone marrow:8.79 adipose:9.24 bone:- skin:8.84
CAGE cerebrum:4.22 cerebellum:- brain stem:4.44 corpus callosum/glia:4.62 pineal gland:4.48 peripheral nerve:- spine:4.85 retina:- eye:- artery/aorta:4.04 vein:3.65 lymphnode:3.67 peripheral blood:- spleen:4.09 thymus:3.92 bone marrow:- adipose:4.54 bone:- skin:-
RNA-seq cerebrum:2.92 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:3.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.61 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:91.10 placenta:69.20 prostate:56.30 ovary:111.80 testis:60.60 heart:63.90 muscle:60.30 esophagus:- stomach:85 intestine:- colon:67.80     liver/hepato:137.20        lung:73.30    bladder:- kidney:62.40 pituitary:463.90 thyroid/parathyroid:- adrenal gland:50.80 pancreas:17.80 breast:18.60 salivary:-
GeneChip uterus:9.30 placenta:8.48 prostate:9.08 ovary:9.31 testis:9 heart:8.90 muscle:8.39 esophagus:8.80 stomach:9.19 intestine:8.73 colon:8.09 liver/hepato:8.09 lung:9.19 bladder:- kidney:8.22 pituitary:8.69 thyroid/parathyroid:9.10 adrenal gland:8.87 pancreas:8.35 breast:9.38 salivary:8.02
CAGE uterus:4.39 placenta:4.32 prostate:4.25 ovary:4.20 testis:4.12 heart:4.15 muscle:3.87 esophagus:4.12 stomach:- intestine:3.93 colon:3.88     liver/hepato:3.21    lung:4.16 bladder:4.58 kidney:3.79 pituitary:4.06 thyroid/parathyroid:3.86 adrenal gland:- pancreas:3.87 breast:3.90 salivary:2.97
RNA-seq uterus:- placenta:- prostate:3.03 ovary:3.75 testis:3.64 heart:2.09 muscle:1.21 esophagus:- stomach:- intestine:- colon:3.59     liver/hepato:1.40        lung:2.74    bladder:- kidney:2.20 pituitary:- thyroid/parathyroid:3.35 adrenal gland:3.87 pancreas:- breast:4.15 salivary:-

Gene Information

IDs

Refseq ID NM_203284
Gene ID 3516
Unigene ID Hs.479396
Probe set ID 211974_x_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000168214
GTEx ID ENSG00000168214

Orthologous Gene

Mouse[6]  NM_001080927, NM_001080928, NM_009035
Rat[1]  NM_001106631, NM_001080928, NM_009035

Chromosomal Region

4p15.2  [26,165,077  -  26,436,541]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

2556644
7625272
7651391
8406481
8676443
8749394
8889548
8895530
9032325
9111040
9290259
9694793
9874765
10508479
10637481
10644367
10708423
10713164
10747963
11390662
11404076
11509665
11518718
11748221
11997524
12374742
12477932
12644465
12832621
14570916
14611647
14645224
14701863
14702039
14999091
15187023
15194757
15489334
15546612
15710417
15987768
16287852
16354684
16378632
16399505
16439682
16510869
16530044
16763620
16873269
17055026
17070841
17245125
17284587
17434929
17513037
17513780
17526737
17636029
18155729
18239137
18332109
18663143
19147558
19237563
19240061
19247952
19322201
19487031
19503073
19776126
19800882
19838210
19939918
19969318
20006367
20028974
20231316
20346360
20379614
20453842
20511547
21150319
21440926
21507979
21518914
21558417
21737748
21820430
21832049
21880753
21900206
21988832
21991380
22100894
22143792
22253595
22279058
22279105
22302987
22325781
22366521
22379092
22792167
22883147
22915591
23022380
23103515
23365452
23696732
23775085
24449572

Gene Ontology  (GO ID)

Biological Process

GO:0001525  angiogenesis
GO:0060844  arterial endothelial cell fate commitment
GO:0009912  auditory receptor cell fate commitment
GO:0030183  B cell differentiation
GO:0001974  blood vessel remodeling
GO:0003214  cardiac left ventricle morphogenesis
GO:0042742  defense response to bacterium
GO:0006310  DNA recombination
GO:0003160  endocardium morphogenesis
GO:0009957  epidermal cell fate specification
GO:0001837  epithelial to mesenchymal transition
GO:0003198  epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0010467  gene expression
GO:0048820  hair follicle maturation
GO:0006959  humoral immune response
GO:0002437  inflammatory response to antigenic stimulus
GO:0030216  keratinocyte differentiation
GO:0060716  labyrinthine layer blood vessel development
GO:0008285  negative regulation of cell proliferation
GO:0030279  negative regulation of ossification
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0007219  Notch signaling pathway
GO:0003151  outflow tract morphogenesis
GO:0021983  pituitary gland development
GO:0030513  positive regulation of BMP signaling pathway
GO:0060045  positive regulation of cardiac muscle cell proliferation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0007221  positive regulation of transcription of Notch receptor target
GO:0048505  regulation of timing of cell differentiation
GO:0003256  regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0048733  sebaceous gland development
GO:0035019  somatic stem cell maintenance
GO:0006367  transcription initiation from RNA polymerase II promoter
GO:0003222  ventricular trabecular myocardium morphogenesis

Cellular Component

GO:0005737  cytoplasm
GO:0005730  nucleolus
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0005667  transcription factor complex

Molecular Function

GO:0003682  chromatin binding
GO:0003677  DNA binding
GO:0005515  protein binding
GO:0047485  protein N-terminus binding
GO:0000150  recombinase activity
GO:0003700  transcription factor activity