integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

Synonym

LFA1A, LFA-1A, ITGAL, CD11a antigen, CD11A, Integrin alpha-L precursor, Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:7.10

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:30.70

spine:-

retina:237.30

eye:-

artery/aorta:-

vein:-

lymphnode:161.80

peripheral blood:200.40

spleen:321.40

thymus:463.80

bone marrow:275.50

adipose:-

bone:-

skin:33.60

GeneChip

cerebrum:4.98

cerebellum:4.93

brain stem:5.11

corpus callosum/glia:5.17

pineal gland:-

peripheral nerve:4.95

spine:5.05

retina:-

eye:-

artery/aorta:5.23

vein:5.35

lymphnode:8.11

peripheral blood:-

spleen:8.45

thymus:7.69

bone marrow:6.58

adipose:5.58

bone:-

skin:5.34

CAGE

cerebrum:0.74

cerebellum:-

brain stem:1.54

corpus callosum/glia:1.94

pineal gland:0.26

peripheral nerve:-

spine:1.80

retina:-

eye:-

artery/aorta:2.05

vein:4.06

lymphnode:4.23

peripheral blood:-

spleen:4.00

thymus:4.86

bone marrow:-

adipose:1.79

bone:-

skin:-

RNA-seq

cerebrum:0.24

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:3.50

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.54

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:45.60

placenta:10.90

prostate:11.30

ovary:-

testis:13

heart:-

muscle:40.20

esophagus:-

stomach:63.70

intestine:-

colon:-

liver/hepato:-

lung:29.30

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:18.60

salivary:-

GeneChip

uterus:5.14

placenta:4.96

prostate:4.81

ovary:5.27

testis:4.54

heart:5.20

muscle:4.98

esophagus:5.32

stomach:6.01

intestine:5.43

colon:5.66

liver/hepato:6.40

lung:6.85

bladder:-

kidney:4.98

pituitary:4.97

thyroid/parathyroid:5.20

adrenal gland:5.15

pancreas:5.39

breast:5.27

salivary:5.50

CAGE

uterus:1.48

placenta:1.45

prostate:1.51

ovary:1.37

testis:0.69

heart:1.07

muscle:0.40

esophagus:1.75

stomach:-

intestine:2.46

colon:2.32

liver/hepato:1.95

lung:3.35

bladder:1.35

kidney:0.92

pituitary:0.99

thyroid/parathyroid:0.79

adrenal gland:-

pancreas:1.21

breast:0.90

salivary:2.31

RNA-seq

uterus:-

placenta:-

prostate:0.00

ovary:0.98

testis:0.20

heart:0.08

muscle:0.14

esophagus:-

stomach:-

intestine:-

colon:0.33

liver/hepato:1.06

lung:2.89

bladder:-

kidney:0.23

pituitary:-

thyroid/parathyroid:0.40

adrenal gland:3.25

pancreas:-

breast:0.36

salivary:-

IDs

Refseq ID	NM_001114380
Gene ID	3683
Unigene ID	Hs.174103
Probe set ID	213475_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000005844
GTEx ID	ENSG00000005844

Orthologous Gene

Mouse[1]	NM_008400
Rat[1]	NM_001033998

Chromosomal Region

16p11.2 [30,483,983 - 30,534,505]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR013517	FG-GAP
IPR013519	Integrin alpha beta-propellor

Gene Ontology (GO ID)

Biological Process

GO:0050798	activated T cell proliferation
GO:0007596	blood coagulation
GO:0007155	cell adhesion
GO:0006928	cellular component movement
GO:0007157	heterophilic cell adhesion
GO:0006954	inflammatory response
GO:0007229	integrin-mediated signaling pathway
GO:0007159	leukocyte adhesion
GO:0050900	leukocyte migration
GO:0050850	positive regulation of calcium-mediated signaling
GO:0022409	positive regulation of cell-cell adhesion
GO:0042102	positive regulation of T cell proliferation
GO:0050776	regulation of immune response
GO:0007165	signal transduction
GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

Cellular Component

GO:0009897	external side of plasma membrane
GO:0001772	immunological synapse
GO:0008305	integrin complex
GO:0005886	plasma membrane

Molecular Function

GO:0050839	cell adhesion molecule binding
GO:0046872	metal ion binding

integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function