Janus kinase 3

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Synonym

JAKL, Leukocyte janus kinase, JAK3, LJAK, L-JAK, JAK-3, Janus kinase 3, Tyrosine-protein kinase JAK3, JAK3_HUMAN

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:1.20

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:30

vein:-

lymphnode:40.40

peripheral blood:54.70

spleen:37.80

thymus:25.80

bone marrow:19.70

adipose:40.30

bone:12.80

skin:4.80

GeneChip

cerebrum:5.95

cerebellum:6.11

brain stem:5.93

corpus callosum/glia:5.93

pineal gland:-

peripheral nerve:5.75

spine:5.86

retina:-

eye:-

artery/aorta:5.85

vein:6.06

lymphnode:6.04

peripheral blood:-

spleen:5.79

thymus:5.60

bone marrow:6.02

adipose:6.02

bone:-

skin:5.80

CAGE

cerebrum:1.67

cerebellum:-

brain stem:2.19

corpus callosum/glia:1.46

pineal gland:1.55

peripheral nerve:-

spine:3.21

retina:-

eye:-

artery/aorta:2.28

vein:3.97

lymphnode:4.68

peripheral blood:-

spleen:4.22

thymus:3.78

bone marrow:-

adipose:2.96

bone:-

skin:-

RNA-seq

cerebrum:1.18

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:4.84

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.34

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:18.20

placenta:3.60

prostate:-

ovary:37.30

testis:-

heart:38.30

muscle:-

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:-

lung:9.80

bladder:-

kidney:-

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

GeneChip

uterus:5.78

placenta:5.72

prostate:5.39

ovary:5.92

testis:5.57

heart:6.01

muscle:5.97

esophagus:5.79

stomach:5.89

intestine:5.92

colon:6.09

liver/hepato:5.99

lung:5.83

bladder:-

kidney:6.02

pituitary:6.18

thyroid/parathyroid:5.74

adrenal gland:5.87

pancreas:6.12

breast:5.73

salivary:5.88

CAGE

uterus:1.44

placenta:2.20

prostate:2.06

ovary:2.51

testis:1.25

heart:2.29

muscle:0.86

esophagus:2.09

stomach:-

intestine:2.31

colon:2.49

liver/hepato:1.71

lung:2.94

bladder:2.16

kidney:1.80

pituitary:1.38

thyroid/parathyroid:1.91

adrenal gland:-

pancreas:1.59

breast:1.36

salivary:2.01

RNA-seq

uterus:-

placenta:-

prostate:1.39

ovary:2.76

testis:1.67

heart:0.52

muscle:0.24

esophagus:-

stomach:-

intestine:-

colon:0.79

liver/hepato:0.45

lung:2.77

bladder:-

kidney:0.79

pituitary:-

thyroid/parathyroid:0.63

adrenal gland:4.68

pancreas:-

breast:0.88

salivary:-

IDs

Refseq ID	NM_000215
Gene ID	3718
Unigene ID	Hs.515247
Probe set ID	207187_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000105639
GTEx ID	ENSG00000105639

Orthologous Gene

Mouse[3]	NM_001190830, NM_010589
Rat [0]

Chromosomal Region

19p13.11 [17,935,589 - 17,958,880]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

LRG_77 [4,960 - 28,210]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0030183	B cell differentiation
GO:0007167	enzyme linked receptor protein signaling pathway
GO:0045087	innate immune response
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0002731	negative regulation of dendritic cell cytokine production
GO:0045221	negative regulation of FasL biosynthetic process
GO:0032693	negative regulation of interleukin-10 production
GO:0032695	negative regulation of interleukin-12 production
GO:0050868	negative regulation of T cell activation
GO:0045626	negative regulation of T-helper 1 cell differentiation
GO:0070244	negative regulation of thymocyte apoptosis
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0006468	protein amino acid phosphorylation
GO:0007243	protein kinase cascade
GO:0070232	regulation of T cell apoptosis
GO:0070672	response to interleukin-15
GO:0070669	response to interleukin-2
GO:0070670	response to interleukin-4
GO:0071104	response to interleukin-9
GO:0007262	STAT protein nuclear translocation
GO:0043029	T cell homeostasis
GO:0007260	tyrosine phosphorylation of STAT protein

Cellular Component

GO:0005856	cytoskeleton
GO:0005829	cytosol
GO:0012505	endomembrane system
GO:0016020	membrane

Molecular Function

GO:0005524	ATP binding
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0019903	protein phosphatase binding
GO:0004713	protein tyrosine kinase activity

IPR019749	Band 4.1 domain
IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR020685	Tyrosine-protein kinase
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020933	Tyrosine-protein kinase, fibroblast growth factor receptor, conserved region
IPR016251	Tyrosine-protein kinase, non-receptor Jak/Tyk2
IPR020775	Tyrosine-protein kinase, non-receptor Jak3
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Janus kinase 3

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function