Janus kinase 3

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Synonym

JAKL, Leukocyte janus kinase, JAK3, LJAK, L-JAK, JAK-3, Janus kinase 3, Tyrosine-protein kinase JAK3, JAK3_HUMAN

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:30 vein:- lymphnode:40.40 peripheral blood:54.70 spleen:37.80 thymus:25.80 bone marrow:19.70 adipose:40.30 bone:12.80 skin:4.80
GeneChip cerebrum:3.15 cerebellum:3.17 brain stem:3.19 corpus callosum/glia:3.12 pineal gland:- peripheral nerve:3.08 spine:3.04 retina:- eye:- artery/aorta:3.12 vein:3.43 lymphnode:3.18 peripheral blood:- spleen:3.09 thymus:3.25 bone marrow:3.39 adipose:3.24 bone:- skin:3.31
CAGE cerebrum:1.67 cerebellum:- brain stem:2.19 corpus callosum/glia:1.46 pineal gland:1.55 peripheral nerve:- spine:3.21 retina:- eye:- artery/aorta:2.28 vein:3.97 lymphnode:4.68 peripheral blood:- spleen:4.22 thymus:3.78 bone marrow:- adipose:2.96 bone:- skin:-
RNA-seq cerebrum:1.18 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.84 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.34 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:18.20 placenta:3.60 prostate:- ovary:37.30 testis:- heart:38.30 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:9.80    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:3.04 placenta:3.18 prostate:2.96 ovary:3.16 testis:3.02 heart:3.16 muscle:3.43 esophagus:3.24 stomach:3.06 intestine:3.37 colon:3.25 liver/hepato:3.06 lung:3.15 bladder:- kidney:3.19 pituitary:3.06 thyroid/parathyroid:3.03 adrenal gland:2.99 pancreas:3.15 breast:3.08 salivary:3.19
CAGE uterus:1.44 placenta:2.20 prostate:2.06 ovary:2.51 testis:1.25 heart:2.29 muscle:0.86 esophagus:2.09 stomach:- intestine:2.31 colon:2.49     liver/hepato:1.71    lung:2.94 bladder:2.16 kidney:1.80 pituitary:1.38 thyroid/parathyroid:1.91 adrenal gland:- pancreas:1.59 breast:1.36 salivary:2.01
RNA-seq uterus:- placenta:- prostate:1.39 ovary:2.76 testis:1.67 heart:0.52 muscle:0.24 esophagus:- stomach:- intestine:- colon:0.79     liver/hepato:0.45        lung:2.77    bladder:- kidney:0.79 pituitary:- thyroid/parathyroid:0.63 adrenal gland:4.68 pancreas:- breast:0.88 salivary:-

IDs

Refseq ID NM_000215
Gene ID 3718
Unigene ID Hs.515247
Probe set ID 211108_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000105639
GTEx ID ENSG00000105639

Orthologous Gene

Mouse[3]  NM_001190830, NM_010589
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

Gene Ontology  (GO ID)

Biological Process

GO:0030183  B cell differentiation
GO:0007167  enzyme linked receptor protein signaling pathway
GO:0045087  innate immune response
GO:0060397  JAK-STAT cascade involved in growth hormone signaling pathway
GO:0002731  negative regulation of dendritic cell cytokine production
GO:0045221  negative regulation of FasL biosynthetic process
GO:0032693  negative regulation of interleukin-10 production
GO:0032695  negative regulation of interleukin-12 production
GO:0050868  negative regulation of T cell activation
GO:0045626  negative regulation of T-helper 1 cell differentiation
GO:0070244  negative regulation of thymocyte apoptosis
GO:0018108  peptidyl-tyrosine phosphorylation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0006468  protein amino acid phosphorylation
GO:0007243  protein kinase cascade
GO:0070232  regulation of T cell apoptosis
GO:0070672  response to interleukin-15
GO:0070669  response to interleukin-2
GO:0070670  response to interleukin-4
GO:0071104  response to interleukin-9
GO:0007262  STAT protein nuclear translocation
GO:0043029  T cell homeostasis
GO:0007260  tyrosine phosphorylation of STAT protein

Cellular Component

GO:0005856  cytoskeleton
GO:0005829  cytosol
GO:0012505  endomembrane system
GO:0016020  membrane

Molecular Function

GO:0005524  ATP binding
GO:0004715  non-membrane spanning protein tyrosine kinase activity
GO:0005515  protein binding
GO:0019903  protein phosphatase binding
GO:0004713  protein tyrosine kinase activity