lipopolysaccharide binding protein

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Synonym

lipopolysaccharide binding protein, Lipopolysaccharide-binding protein precursor, lipopolysaccharide-binding protein, MGC22233, LBP

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:12.80 skin:-
GeneChip cerebrum:3.81 cerebellum:3.75 brain stem:3.77 corpus callosum/glia:3.65 pineal gland:- peripheral nerve:3.80 spine:3.81 retina:- eye:- artery/aorta:4.01 vein:3.98 lymphnode:3.95 peripheral blood:- spleen:3.81 thymus:3.87 bone marrow:4.54 adipose:4.09 bone:- skin:4.03
CAGE cerebrum:0.12 cerebellum:- brain stem:0 corpus callosum/glia:0.07 pineal gland:0 peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0.95 vein:0.34 lymphnode:0.94 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:1.93 bone:- skin:-
RNA-seq cerebrum:0.06 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.95 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.63 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:11.30 ovary:- testis:- heart:25.50 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:369.40        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:3.79 placenta:3.61 prostate:3.80 ovary:3.70 testis:3.64 heart:4.38 muscle:5.25 esophagus:3.74 stomach:3.70 intestine:3.73 colon:4.12 liver/hepato:9.17 lung:3.73 bladder:- kidney:4.12 pituitary:3.79 thyroid/parathyroid:3.68 adrenal gland:3.88 pancreas:3.90 breast:4.12 salivary:3.87
CAGE uterus:0.19 placenta:1.22 prostate:0.33 ovary:0.86 testis:0 heart:1.45 muscle:2.01 esophagus:0 stomach:- intestine:0.07 colon:0.67     liver/hepato:8.00    lung:0.05 bladder:1.12 kidney:3.22 pituitary:0 thyroid/parathyroid:2.39 adrenal gland:- pancreas:0.58 breast:0.55 salivary:0
RNA-seq uterus:- placenta:- prostate:0.28 ovary:0.09 testis:0.66 heart:0.33 muscle:1.37 esophagus:- stomach:- intestine:- colon:1.96     liver/hepato:9.90        lung:0.03    bladder:- kidney:3.93 pituitary:- thyroid/parathyroid:3.08 adrenal gland:3.45 pancreas:- breast:1.56 salivary:-

Gene Information

IDs

Refseq ID NM_004139
Gene ID 3929
Unigene ID Hs.154078
Probe set ID 214461_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000129988
GTEx ID ENSG00000129988

Orthologous Gene

Mouse[1]  NM_008489
Rat [0]  

Chromosomal Region

20q11.23  [36,974,759  -  37,005,665]

Gene Family (Interpro ID)

IPR017943  Bactericidal permeability-increasing protein, alpha/beta domain
IPR001124  Lipid-binding serum glycoprotein, C-terminal
IPR017942  Lipid-binding serum glycoprotein, N-terminal

Link to Pubmed  (Pubmed ID)

2402637
2477488
7517398
7583357
8409400
8432532
8663389
8985160
9179291
9240454
9338787
9441745
9568897
9665271
10079194
10453023
10768924
10811873
10919979
11373419
11528597
11544322
11598069
11739189
11773072
11780052
11976738
11991204
12117913
12417309
12477932
12521224
12538700
12594207
12615620
12754215
12831460
12932360
14718574
15127192
15618154
15932345
16303759
16493079
16512634
16907704
16928689
18029348
18056482
18056918
18288274
18397383
18559343
18783308
18987746
19010986
19056867
19200604
19423540
19522765
19560454
19707138
19718443
19913121
20346360
20379614
20381257
20406964
20438785
20530747
20628086
20800603
20865702
21353369
21633598
21702700
21722015
21740312
21901123
21988832
22476641
22552880
22736337
22960476
23349936
23382691
23430250
23463341
24024966
24120359
24276451

Gene Ontology  (GO ID)

Biological Process

GO:0006953  acute-phase response
GO:0006968  cellular defense response
GO:0071222  cellular response to lipopolysaccharide
GO:0071223  cellular response to lipoteichoic acid
GO:0050829  defense response to Gram-negative bacterium
GO:0050830  defense response to Gram-positive bacterium
GO:0032490  detection of molecule of bacterial origin
GO:0045087  innate immune response
GO:0002232  leukocyte chemotaxis during inflammatory response
GO:0015920  lipopolysaccharide transport
GO:0031663  lipopolysaccharide-mediated signaling pathway
GO:0002281  macrophage activation during immune response
GO:0044130  negative regulation of growth of symbiont in host
GO:0032720  negative regulation of tumor necrosis factor production
GO:0008228  opsonization
GO:0032722  positive regulation of chemokine production
GO:0032755  positive regulation of interleukin-6 production
GO:0032757  positive regulation of interleukin-8 production
GO:0043032  positive regulation of macrophage activation
GO:0090023  positive regulation of neutrophil chemotaxis
GO:0060265  positive regulation of respiratory burst during acute inflammatory response
GO:0034145  positive regulation of toll-like receptor 4 signaling pathway
GO:0042535  positive regulation of tumor necrosis factor biosynthetic process
GO:0032760  positive regulation of tumor necrosis factor production
GO:0032496  response to lipopolysaccharide
GO:0034142  toll-like receptor 4 signaling pathway
GO:0002224  toll-like receptor signaling pathway

Cellular Component

GO:0009986  cell surface
GO:0005576  extracellular region
GO:0005615  extracellular space

Molecular Function

GO:0001530  lipopolysaccharide binding
GO:0070891  lipoteichoic acid binding
GO:0005515  protein binding
GO:0005102  receptor binding