myocyte enhancer factor 2C

 jump to detail

Synonym

Myocyte-specific enhancer factor 2C, MEF2C

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST nodata
GeneChip cerebrum:7.87 cerebellum:5.99 brain stem:6.54 corpus callosum/glia:7.08 pineal gland:- peripheral nerve:7.05 spine:7.22 retina:- eye:- artery/aorta:7.75 vein:7.36 lymphnode:8.29 peripheral blood:- spleen:8.53 thymus:6.44 bone marrow:6.65 adipose:7.72 bone:- skin:6.84
CAGE cerebrum:5.17 cerebellum:- brain stem:4.30 corpus callosum/glia:4.61 pineal gland:5.14 peripheral nerve:- spine:4.72 retina:- eye:- artery/aorta:5.07 vein:5.11 lymphnode:5.05 peripheral blood:- spleen:5.40 thymus:3.46 bone marrow:- adipose:5.21 bone:- skin:-
RNA-seq cerebrum:4.77 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.61 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.53 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST nodata
GeneChip uterus:7.58 placenta:7.13 prostate:6.74 ovary:7.72 testis:6.03 heart:7.64 muscle:10.96 esophagus:7.15 stomach:6.98 intestine:7.33 colon:6.61 liver/hepato:6.03 lung:6.85 bladder:- kidney:5.85 pituitary:6.97 thyroid/parathyroid:7.03 adrenal gland:7.57 pancreas:5.34 breast:7.21 salivary:5.59
CAGE uterus:5.04 placenta:4.34 prostate:4.44 ovary:4.81 testis:3.83 heart:4.72 muscle:4.40 esophagus:4.28 stomach:- intestine:3.60 colon:4.02     liver/hepato:3.28    lung:4.70 bladder:4.85 kidney:3.74 pituitary:4.53 thyroid/parathyroid:3.91 adrenal gland:- pancreas:2.08 breast:4.47 salivary:3.71
RNA-seq uterus:- placenta:- prostate:1.23 ovary:1.10 testis:1.73 heart:1.38 muscle:1.04 esophagus:- stomach:- intestine:- colon:1.92     liver/hepato:0.47        lung:1.98    bladder:- kidney:0.47 pituitary:- thyroid/parathyroid:1.33 adrenal gland:2.69 pancreas:- breast:2.38 salivary:-

Gene Information

IDs

Refseq ID NM_002397
Gene ID 4208
Unigene ID -
Probe set ID 209199_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000081189
GTEx ID ENSG00000081189

Orthologous Gene

Mouse[20]  NM_001170537, NM_025282
Rat[20]  NM_001170537, NM_025282

Chromosomal Region

5q14.3  [88,013,975  -  88,199,922]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

7679508
8455629
8548800
8575763
8575784
8663403
8900141
8948587
9001254
9069290
9384584
9418854
9748305
9753748
9770491
9798649
9857019
9858528
10082551
10330143
10458488
10523670
10737771
10790371
10805738
11160896
11279209
11486037
11504882
11535832
11554755
11744164
11792813
11809751
12061776
12130539
12135755
12376544
12477932
12659851
12709441
12861002
15084602
15140898
15276183
15340086
15342556
15486975
15561718
15743821
15743823
15831463
15834131
15923648
15964851
16043483
16469744
16478538
16504037
16510869
17611778
17696759
17903302
18029348
18067759
18079734
18332106
18463162
18588859
18660489
18950845
19011954
19065516
19093215
19453261
19553684
19592390
19720801
19751190
19801982
19828686
19913121
20211142
20333642
20412115
20513142
20610535
20628086
20709755
20881960
20936779
21060863
21481790
21533022
21652706
21849497
21890473
21901155
21906983
21988832
22073279
22139419
22275376
22363514
22449245
22504420
22670137
22718505
22798246
22997707
23001426
23174904
23226416
23382706
23389741
23400010
23402836
23468913
23572186
23776548
24008018
24162737
24249740
24290359

Gene Ontology  (GO ID)

Biological Process

GO:0006915  apoptosis
GO:0001782  B cell homeostasis
GO:0042100  B cell proliferation
GO:0050853  B cell receptor signaling pathway
GO:0001568  blood vessel development
GO:0001974  blood vessel remodeling
GO:0014898  cardiac muscle hypertrophy in response to stress
GO:0003211  cardiac ventricle formation
GO:0060536  cartilage morphogenesis
GO:0071277  cellular response to calcium ion
GO:0071498  cellular response to fluid shear stress
GO:0071333  cellular response to glucose stimulus
GO:0071222  cellular response to lipopolysaccharide
GO:0071374  cellular response to parathyroid hormone stimulus
GO:0071300  cellular response to retinoic acid
GO:0002062  chondrocyte differentiation
GO:0021542  dentate gyrus development
GO:0048703  embryonic viscerocranium morphogenesis
GO:0001958  endochondral ossification
GO:0002467  germinal center formation
GO:0007507  heart development
GO:0001947  heart looping
GO:0006959  humoral immune response
GO:0045087  innate immune response
GO:0007611  learning or memory
GO:0000165  MAPKKK cascade
GO:0030318  melanocyte differentiation
GO:0030224  monocyte differentiation
GO:0042692  muscle cell differentiation
GO:0007521  muscle cell fate determination
GO:0007517  muscle organ development
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0014902  myotube differentiation
GO:0050680  negative regulation of epithelial cell proliferation
GO:0010629  negative regulation of gene expression
GO:0043524  negative regulation of neuron apoptosis
GO:0030279  negative regulation of ossification
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0048011  nerve growth factor receptor signaling pathway
GO:0007399  nervous system development
GO:0014033  neural crest cell differentiation
GO:0048666  neuron development
GO:0030182  neuron differentiation
GO:0001649  osteoblast differentiation
GO:0003151  outflow tract morphogenesis
GO:0060021  palate development
GO:0030220  platelet formation
GO:0010694  positive regulation of alkaline phosphatase activity
GO:0030890  positive regulation of B cell proliferation
GO:0030501  positive regulation of bone mineralization
GO:0060045  positive regulation of cardiac muscle cell proliferation
GO:0010628  positive regulation of gene expression
GO:0051149  positive regulation of muscle cell differentiation
GO:0045663  positive regulation of myoblast differentiation
GO:0045666  positive regulation of neuron differentiation
GO:0045669  positive regulation of osteoblast differentiation
GO:0090073  positive regulation of protein homodimerization activity
GO:0048643  positive regulation of skeletal muscle tissue development
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0003138  primary heart field specification
GO:0002634  regulation of germinal center formation
GO:0045652  regulation of megakaryocyte differentiation
GO:0060297  regulation of sarcomere organization
GO:0060025  regulation of synaptic activity
GO:0009615  response to virus
GO:0033197  response to vitamin E
GO:0003139  secondary heart field specification
GO:0003185  sinoatrial valve morphogenesis
GO:0007519  skeletal muscle tissue development
GO:0051145  smooth muscle cell differentiation
GO:0051403  stress-activated MAPK cascade
GO:0034166  toll-like receptor 10 signaling pathway
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0034146  toll-like receptor 5 signaling pathway
GO:0034162  toll-like receptor 9 signaling pathway
GO:0002224  toll-like receptor signaling pathway
GO:0055012  ventricular cardiac muscle cell differentiation

Cellular Component

GO:0005737  cytoplasm
GO:0043231  intracellular membrane-bounded organelle
GO:0016607  nuclear speck
GO:0005730  nucleolus
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0043234  protein complex

Molecular Function

GO:0003680  AT DNA binding
GO:0003682  chromatin binding
GO:0003677  DNA binding
GO:0044212  DNA regulatory region binding
GO:0042826  histone deacetylase binding
GO:0035198  miRNA binding
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0003705  RNA polymerase II transcription factor activity, enhancer binding
GO:0033613  transcription activator binding
GO:0003700  transcription factor activity