mitogen-activated protein kinase kinase kinase 1

Synonym

MAPK/ERK kinase kinase 1, MEKK, mitogen-activated protein kinase kinase kinase 1, MAPKKK1, MEK kinase 1, MAP3K1, Mitogen-activated protein kinase kinase kinase 1, MEKK1, MEKK 1

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

nodata

GeneChip

cerebrum:3.13

cerebellum:3.37

brain stem:3.19

corpus callosum/glia:3.28

pineal gland:-

peripheral nerve:3.16

spine:3.08

retina:-

eye:-

artery/aorta:2.92

vein:3.51

lymphnode:3.70

peripheral blood:-

spleen:4.24

thymus:3.34

bone marrow:3.84

adipose:3.34

bone:-

skin:3.43

CAGE

cerebrum:1.76

cerebellum:-

brain stem:2.17

corpus callosum/glia:2.25

pineal gland:2.12

peripheral nerve:-

spine:1.88

retina:-

eye:-

artery/aorta:2.17

vein:3.25

lymphnode:3.32

peripheral blood:-

spleen:3.40

thymus:2.70

bone marrow:-

adipose:2.31

bone:-

skin:-

RNA-seq

cerebrum:1.05

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:3.65

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.09

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

nodata

GeneChip

uterus:3.55

placenta:3.30

prostate:3.12

ovary:3.78

testis:3.10

heart:3.39

muscle:3.18

esophagus:3.55

stomach:3.42

intestine:3.58

colon:3.50

liver/hepato:3.31

lung:3.45

bladder:-

kidney:3.55

pituitary:3.04

thyroid/parathyroid:3.47

adrenal gland:3.22

pancreas:3.88

breast:3.72

salivary:3.67

CAGE

uterus:2.53

placenta:2.44

prostate:2.62

ovary:2.58

testis:2.82

heart:2.18

muscle:1.67

esophagus:2.82

stomach:-

intestine:2.59

colon:2.48

liver/hepato:1.88

lung:2.84

bladder:2.25

kidney:2.66

pituitary:1.97

thyroid/parathyroid:3.24

adrenal gland:-

pancreas:2.26

breast:2.79

salivary:3.05

RNA-seq

uterus:-

placenta:-

prostate:2.40

ovary:3.14

testis:3.16

heart:1.14

muscle:1.13

esophagus:-

stomach:-

intestine:-

colon:1.52

liver/hepato:1.12

lung:2.60

bladder:-

kidney:2.80

pituitary:-

thyroid/parathyroid:3.55

adrenal gland:3.61

pancreas:-

breast:2.77

salivary:-

IDs

Refseq ID	NM_005921
Gene ID	4214
Unigene ID	-
Probe set ID	214786_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000095015
GTEx ID	ENSG00000095015

Orthologous Gene

Mouse[1]	NM_011945
Rat[2]	NM_053887

Chromosomal Region

5q11.2 [56,111,401 - 56,191,979]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain
IPR007527	Zinc finger, SWIM-type

Gene Ontology (GO ID)

Biological Process

GO:0000186	activation of MAPKK activity
GO:0008637	apoptotic mitochondrial changes
GO:0043010	camera-type eye development
GO:0071260	cellular response to mechanical stimulus
GO:0045087	innate immune response
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0030838	positive regulation of actin filament polymerization
GO:0006468	protein amino acid phosphorylation
GO:0030334	regulation of cell migration
GO:0034166	toll-like receptor 10 signaling pathway
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0002224	toll-like receptor signaling pathway
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0042060	wound healing

Cellular Component

GO:0005829

cytosol

Molecular Function

GO:0005524	ATP binding
GO:0008545	JUN kinase kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0005515	protein binding
GO:0004672	protein kinase activity
GO:0019901	protein kinase binding
GO:0008270	zinc ion binding

mitogen-activated protein kinase kinase kinase 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function