msh homeobox 2

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Synonym

msh homeobox homolog 2 (Drosophila), FPP, CRS2, parietal foramina 1, msh (Drosophila) homeo box homolog 2, Homeobox protein MSX-2, Hox-8, MSH, HOX8, PFM, msh homeo box homolog 2 (Drosophila), MSX2

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:12.60 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:11.80 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:19.70 adipose:- bone:- skin:9.60
GeneChip cerebrum:2.86 cerebellum:3.11 brain stem:2.97 corpus callosum/glia:3.09 pineal gland:- peripheral nerve:2.86 spine:3.69 retina:- eye:- artery/aorta:2.87 vein:3.04 lymphnode:2.77 peripheral blood:- spleen:2.78 thymus:2.69 bone marrow:2.82 adipose:2.79 bone:- skin:3.37
CAGE cerebrum:0.83 cerebellum:- brain stem:1.07 corpus callosum/glia:1.19 pineal gland:0.26 peripheral nerve:- spine:2.41 retina:- eye:- artery/aorta:0.59 vein:0.47 lymphnode:0.22 peripheral blood:- spleen:0.92 thymus:0 bone marrow:- adipose:0.55 bone:- skin:-
RNA-seq cerebrum:0.55 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.34 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.34 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:69.20 prostate:- ovary:- testis:4.30 heart:25.50 muscle:- esophagus:- stomach:42.50 intestine:- colon:17     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:9.30 salivary:-
GeneChip uterus:3.92 placenta:5.36 prostate:3.07 ovary:2.70 testis:3.82 heart:2.88 muscle:2.76 esophagus:2.77 stomach:3.04 intestine:2.84 colon:2.89 liver/hepato:2.88 lung:2.78 bladder:- kidney:2.67 pituitary:2.73 thyroid/parathyroid:2.88 adrenal gland:2.87 pancreas:2.76 breast:4.05 salivary:2.69
CAGE uterus:1.35 placenta:3.87 prostate:2.14 ovary:0.42 testis:2.07 heart:0.88 muscle:1.19 esophagus:0.77 stomach:- intestine:0.53 colon:0.61     liver/hepato:0    lung:0.40 bladder:2.69 kidney:0.33 pituitary:0.26 thyroid/parathyroid:0.73 adrenal gland:- pancreas:0 breast:2.02 salivary:0
RNA-seq uterus:- placenta:- prostate:2.40 ovary:0.23 testis:2.04 heart:0.55 muscle:0.88 esophagus:- stomach:- intestine:- colon:0.30     liver/hepato:0.01        lung:0.28    bladder:- kidney:0.40 pituitary:- thyroid/parathyroid:0.65 adrenal gland:0.36 pancreas:- breast:0.72 salivary:-

Gene Information

IDs

Refseq ID NM_002449
Gene ID 4488
Unigene ID Hs.89404
Probe set ID 210319_x_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000120149
GTEx ID ENSG00000120149

Orthologous Gene

Mouse[1]  NM_013601
Rat [0]  

Chromosomal Region

5q35.2  [174,151,536  -  174,158,144]

Gene Family (Interpro ID)

IPR001356  Homeobox
IPR009057  Homeodomain-like
IPR012287  Homeodomain-related

Link to Pubmed  (Pubmed ID)

7687426
7726844
7897272
8101453
8106171
8668339
8786091
8968743
9073066
9111364
9256341
9265625
9373945
9522127
10451362
10742103
10767351
10831122
11084035
11683913
11763998
11959851
12145306
12145307
12145310
12407713
12477932
12750290
12925529
14571277
14679154
15060165
15214020
15489334
16327884
16425399
16467978
16540516
16642368
17693062
17955513
18000908
18029348
18056036
18187185
18299954
18349132
18786927
19147956
19240061
19407244
19453261
19590514
19835636
20004646
20107842
20211142
20301307
20506112
20538960
20572854
20620318
20634891
20672350
20682066
21362336
21465479
21471203
21498730
21499300
21512281
21730974
21906983
22332551
22633971
22717651
22730815
23275563
23949913

Gene Ontology  (GO ID)

Biological Process

GO:0042640  anagen
GO:0009952  anterior/posterior pattern formation
GO:0060346  bone trabecula formation
GO:0060444  branching involved in mammary gland duct morphogenesis
GO:0071392  cellular response to estradiol stimulus
GO:0071363  cellular response to growth factor stimulus
GO:0002063  chondrocyte development
GO:0060363  cranial suture morphogenesis
GO:0035115  embryonic forelimb morphogenesis
GO:0035116  embryonic hindlimb morphogenesis
GO:0070166  enamel mineralization
GO:0003416  endochondral bone growth
GO:0003198  epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0060364  frontal suture morphogenesis
GO:0043066  negative regulation of apoptosis
GO:0008285  negative regulation of cell proliferation
GO:0032792  negative regulation of CREB transcription factor activity
GO:0045599  negative regulation of fat cell differentiation
GO:0045617  negative regulation of keratinocyte differentiation
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0002076  osteoblast development
GO:0001649  osteoblast differentiation
GO:0003148  outflow tract septum morphogenesis
GO:0043065  positive regulation of apoptosis
GO:0030513  positive regulation of BMP signaling pathway
GO:0051795  positive regulation of catagen
GO:0045669  positive regulation of osteoblast differentiation
GO:0035313  wound healing, spreading of epidermal cells

Cellular Component

GO:0005737  cytoplasm
GO:0005634  nucleus
GO:0005667  transcription factor complex

Molecular Function

GO:0044212  DNA regulatory region binding
GO:0005515  protein binding
GO:0043565  sequence-specific DNA binding
GO:0003712  transcription cofactor activity
GO:0008134  transcription factor binding