neurogenic differentiation 1

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Synonym

neurogenic differentiation 1, NeuroD1, NeuroD, NEUROD1, BETA2, Neurogenic differentiation factor 1, BHF-1, NEUROD

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:3.91 cerebellum:9.77 brain stem:4.18 corpus callosum/glia:3.54 pineal gland:- peripheral nerve:3.49 spine:3.56 retina:- eye:- artery/aorta:3.57 vein:3.77 lymphnode:3.41 peripheral blood:- spleen:3.40 thymus:3.37 bone marrow:3.59 adipose:3.52 bone:- skin:3.49
CAGE cerebrum:1.83 cerebellum:- brain stem:0.98 corpus callosum/glia:0.29 pineal gland:5.38 peripheral nerve:- spine:0.22 retina:- eye:- artery/aorta:0.79 vein:0 lymphnode:0 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:1.43 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:3.44 placenta:3.55 prostate:3.42 ovary:3.46 testis:3.52 heart:3.60 muscle:3.65 esophagus:3.38 stomach:4.02 intestine:4.14 colon:3.76 liver/hepato:3.50 lung:3.38 bladder:- kidney:3.50 pituitary:3.75 thyroid/parathyroid:3.47 adrenal gland:3.52 pancreas:4.81 breast:3.44 salivary:3.63
CAGE uterus:0.06 placenta:0 prostate:0 ovary:0 testis:0.75 heart:0 muscle:0 esophagus:0 stomach:- intestine:2.33 colon:1.24     liver/hepato:0    lung:0 bladder:0 kidney:0 pituitary:0.98 thyroid/parathyroid:0 adrenal gland:- pancreas:1.87 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0 ovary:0 testis:0.11 heart:0 muscle:0 esophagus:- stomach:- intestine:- colon:0.29     liver/hepato:0        lung:0    bladder:- kidney:0.05 pituitary:- thyroid/parathyroid:0 adrenal gland:0 pancreas:- breast:0.00 salivary:-

Gene Information

IDs

Refseq ID NM_002500
Gene ID 4760
Unigene ID Hs.574626
Probe set ID 206282_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000162992
GTEx ID ENSG00000162992

Orthologous Gene

Mouse[2]  NM_010894
Rat[3]  NM_019218

Chromosomal Region

2q31.3  [182,537,815  -  182,545,603]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

8786144
8915591
9039501
9144558
9308961
9343431
9703340
9714454
10366743
10507539
10545951
10636926
10757985
11575290
11591653
11755474
11788592
11900979
12200761
12476420
12477932
12482979
12639765
12861411
12881483
12890672
12951629
14752053
14759067
15047635
15247487
15277395
15489334
15592940
15650322
15665000
15708351
15815621
15993959
16024661
16026366
16055439
16321269
16321656
16344560
16357810
16569215
16773428
16870135
16873704
16909454
16936201
17126478
17192490
17217914
17327436
17440689
17941991
17985422
18029348
18331410
18339630
18519782
18587321
18811724
19086053
19228875
19307926
19353266
19619559
19913121
20120526
20416077
20573748
20628086
20682687
20692411
21084850
21278380
21349947
21697133
21800309
21988832
22455846
22558175
22761608
23203005
23553831
23739064
24250222

Gene Ontology  (GO ID)

Biological Process

GO:0009952  anterior/posterior pattern formation
GO:0071333  cellular response to glucose stimulus
GO:0021549  cerebellum development
GO:0021542  dentate gyrus development
GO:0048562  embryonic organ morphogenesis
GO:0031018  endocrine pancreas development
GO:0042593  glucose homeostasis
GO:0048839  inner ear development
GO:0030073  insulin secretion
GO:0046426  negative regulation of JAK-STAT cascade
GO:0022008  neurogenesis
GO:0007263  nitric oxide mediated signal transduction
GO:0006913  nucleocytoplasmic transport
GO:0003326  pancreatic A cell fate commitment
GO:0003329  pancreatic PP cell fate commitment
GO:0043065  positive regulation of apoptosis
GO:0045597  positive regulation of cell differentiation
GO:0045666  positive regulation of neuron differentiation
GO:0051091  positive regulation of transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0071156  regulation of cell cycle arrest
GO:0050796  regulation of insulin secretion
GO:0060730  regulation of intestinal epithelial structure maintenance
GO:0042493  response to drug
GO:0009749  response to glucose stimulus

Cellular Component

GO:0005737  cytoplasm
GO:0005654  nucleoplasm
GO:0005634  nucleus

Molecular Function

GO:0003682  chromatin binding
GO:0003690  double-stranded DNA binding
GO:0070888  E-box binding
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0043565  sequence-specific DNA binding
GO:0003713  transcription coactivator activity
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding