nerve growth factor receptor (TNFR superfamily, member 16)

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Synonym

p75(NTR), CD271 antigen, TNFRSF16, p75 ICD, Low affinity neurotrophin receptor p75NTR, Gp80-LNGFR, NGFR, Low-affinity nerve growth factor receptor, CD271, NGF receptor

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:19 cerebellum:50.40 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:449.20 retina:- eye:64.60 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:18.90 thymus:- bone marrow:- adipose:- bone:25.60 skin:-
GeneChip cerebrum:4.96 cerebellum:5.32 brain stem:5.11 corpus callosum/glia:5.04 pineal gland:- peripheral nerve:9.28 spine:5.46 retina:- eye:- artery/aorta:5.55 vein:5.56 lymphnode:5.48 peripheral blood:- spleen:5.97 thymus:4.42 bone marrow:5.10 adipose:5.45 bone:- skin:4.95
CAGE cerebrum:1.71 cerebellum:- brain stem:3.08 corpus callosum/glia:2.97 pineal gland:1.97 peripheral nerve:- spine:3.53 retina:- eye:- artery/aorta:3.30 vein:3.08 lymphnode:2.79 peripheral blood:- spleen:3.47 thymus:0.77 bone marrow:- adipose:2.95 bone:- skin:-
RNA-seq cerebrum:0.80 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.61 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.64 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:29.10 prostate:11.30 ovary:37.30 testis:17.30 heart:51.10 muscle:- esophagus:- stomach:- intestine:- colon:8.50     liver/hepato:-        lung:4.90    bladder:- kidney:- pituitary:- thyroid/parathyroid:163.70 adrenal gland:- pancreas:- breast:18.60 salivary:-
GeneChip uterus:4.75 placenta:5.63 prostate:5.16 ovary:4.68 testis:4.80 heart:5.94 muscle:4.96 esophagus:5.11 stomach:4.95 intestine:5.27 colon:5.39 liver/hepato:6 lung:4.63 bladder:- kidney:4.90 pituitary:4.96 thyroid/parathyroid:5.07 adrenal gland:6.53 pancreas:5.39 breast:5.56 salivary:5.58
CAGE uterus:2.63 placenta:2.77 prostate:3.51 ovary:2.64 testis:2.85 heart:2.90 muscle:1.40 esophagus:3.02 stomach:- intestine:2.10 colon:2.53     liver/hepato:3.78    lung:0.69 bladder:3.14 kidney:2.19 pituitary:2.06 thyroid/parathyroid:3.74 adrenal gland:- pancreas:2.26 breast:2.59 salivary:3.29
RNA-seq uterus:- placenta:- prostate:3.61 ovary:2.09 testis:4.32 heart:1.89 muscle:0.54 esophagus:- stomach:- intestine:- colon:2.82     liver/hepato:2.12        lung:1.54    bladder:- kidney:2.11 pituitary:- thyroid/parathyroid:2.64 adrenal gland:4.83 pancreas:- breast:2.42 salivary:-

IDs

Refseq ID NM_002507
Gene ID 4804
Unigene ID Hs.415768
Probe set ID 205858_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000064300
GTEx ID ENSG00000064300

Orthologous Gene

Mouse[3]  NM_033217
Rat[2]  NM_012610

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

1281863
1316918
1324502
1846035
2850481
2989274
3006050
3008331
3020711
3022937
7541035
7541633
7903404
8407983
8614797
8627329
8889548
9252186
9368064
9575168
9626059
9665396
9867838
9915784
9927421
10022904
10485890
10514511
10544233
10545116
10595511
10764727
10985348
11150334
11201742
11244088
11278287
11279055
11487608
11729324
11756426
11756498
11818506
11830582
11927634
12011108
12034707
12107411
12163480
12371150
12376548
12414813
12422217
12426574
12460612
12477932
12604596
12672029
12676795
12682012
12692556
12716928
12768436
12787561
12789270
12821676
12821936
12843241
12913006
12951563
12963025
14593116
14689592
14960584
14966521
14985763
15015775
15128850
15131306
15165637
15258592
15274039
15310753
15337528
15378608
15489334
15523689
15681836
15694321
15701642
15721744
15784962
15953414
16099913
16113645
16215275
16215672
16344560
16460673
16498402
16555252
16586073
16630834
16704535
16826429
16893414
16951226
16997282
17110619
17196528
17287525
17335080
17349981
17355907
17357149
17492429
17510309
17531524
17582777
17603629
17619016
17696644
17703412
17850422
17947706
17971243
17986144
18029348
18036543
18081157
18196575
18203754
18221326
18305571
18319596
18394312
18428117
18462868
18470533
18477014
18540978
18566344
18780967
19041213
19066726
19072833
19086053
19131967
19169037
19177265
19225519
19240061
19258923
19301169
19386345
19490633
19598235
19615036
19758188
19918800
19945432
20022966
20219210
20237496
20351714
20503287
20530577
20549701
20596026
20659559
20680101
20854189
20943663
21097678
21123453
21142793
21151024
21178583
21307265
21343882
21393506
21397006
21418516
21503896
21807134
21814043
21851375
21900206
21938001
21982860
22040987
22068036
22138126
22161836
22170235
22207443
22236693
22343487
22419851
22454143
22558167
22566094
22610502
22635104
22706116
22710983
22932111
22954667
23017601
23065828
23105112
23105113
23260665
23268325
23300742
23371454
23471969
23489213
23535732
23576602
23598407
23598854
23600400
23616554
23626764
23642664
23820422
23831066
23975178
24026251
24047966
24226422
24519935
24590808
24604282

Gene Ontology  (GO ID)

Biological Process

GO:0007411  axon guidance
GO:0007417  central nervous system development
GO:0016048  detection of temperature stimulus
GO:0042593  glucose homeostasis
GO:0031069  hair follicle morphogenesis
GO:0006917  induction of apoptosis
GO:0006886  intracellular protein transport
GO:0031293  membrane protein intracellular domain proteolysis
GO:0043066  negative regulation of apoptosis
GO:0050771  negative regulation of axonogenesis
GO:0045786  negative regulation of cell cycle
GO:0040037  negative regulation of fibroblast growth factor receptor signaling pathway
GO:0051799  negative regulation of hair follicle development
GO:0021675  nerve development
GO:0048011  nerve growth factor receptor signaling pathway
GO:0043065  positive regulation of apoptosis
GO:0050772  positive regulation of axonogenesis
GO:0048146  positive regulation of fibroblast proliferation
GO:0042488  positive regulation of odontogenesis of dentine-containing tooth
GO:0050770  regulation of axonogenesis
GO:0043281  regulation of caspase activity
GO:0010468  regulation of gene expression

Cellular Component

GO:0009986  cell surface
GO:0005829  cytosol
GO:0005768  endosome
GO:0005576  extracellular region
GO:0005887  integral to plasma membrane
GO:0005654  nucleoplasm
GO:0005886  plasma membrane

Molecular Function

GO:0005035  death receptor activity
GO:0048406  nerve growth factor binding
GO:0005515  protein binding
GO:0017137  Rab GTPase binding
GO:0004872  receptor activity
GO:0004871  signal transducer activity
GO:0004888  transmembrane receptor activity
GO:0031625  ubiquitin protein ligase binding