Notch homolog 4 (Drosophila)

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Synonym

Notch 4, NOTCH4, INT3, MGC74442, Notch (Drosophila) homolog 4, Notch homolog 4 (Drosophila), Neurogenic locus notch homolog protein 4 precursor, NOTCH3, hNotch4

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:21.30 cerebellum:12.60 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:61.30 spine:- retina:- eye:5.90 artery/aorta:- vein:- lymphnode:20.20 peripheral blood:18.20 spleen:37.80 thymus:25.80 bone marrow:- adipose:- bone:38.40 skin:9.60
GeneChip cerebrum:5.95 cerebellum:5.78 brain stem:6.21 corpus callosum/glia:5.85 pineal gland:- peripheral nerve:5.87 spine:5.84 retina:- eye:- artery/aorta:6.18 vein:5.97 lymphnode:5.71 peripheral blood:- spleen:5.59 thymus:4.87 bone marrow:5.67 adipose:6.95 bone:- skin:6.04
CAGE cerebrum:2.11 cerebellum:- brain stem:2.66 corpus callosum/glia:2.13 pineal gland:2.01 peripheral nerve:- spine:2.53 retina:- eye:- artery/aorta:2.38 vein:2.78 lymphnode:1.76 peripheral blood:- spleen:2.28 thymus:0.64 bone marrow:- adipose:4.48 bone:- skin:-
RNA-seq cerebrum:1.03 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:2.74 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.26 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:36.50 placenta:43.70 prostate:22.50 ovary:- testis:17.30 heart:25.50 muscle:- esophagus:- stomach:- intestine:32.40 colon:8.50     liver/hepato:-        lung:39.10    bladder:125.60 kidney:20.80 pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:53.30 breast:46.50 salivary:-
GeneChip uterus:5.97 placenta:6.19 prostate:5.73 ovary:5.53 testis:5.66 heart:6.68 muscle:5.87 esophagus:5.61 stomach:5.94 intestine:6.01 colon:5.87 liver/hepato:6.03 lung:7.08 bladder:- kidney:6.29 pituitary:5.80 thyroid/parathyroid:5.89 adrenal gland:6.32 pancreas:5.94 breast:6.09 salivary:5.36
CAGE uterus:2.91 placenta:2.56 prostate:2.76 ovary:2.35 testis:2.12 heart:3.39 muscle:3.07 esophagus:2.44 stomach:- intestine:1.96 colon:2.51     liver/hepato:2.68    lung:3.92 bladder:2.48 kidney:2.70 pituitary:2.10 thyroid/parathyroid:2.71 adrenal gland:- pancreas:1.42 breast:4.07 salivary:1.39
RNA-seq uterus:- placenta:- prostate:1.72 ovary:1.50 testis:1.16 heart:2.32 muscle:0.72 esophagus:- stomach:- intestine:- colon:2.44     liver/hepato:1.24        lung:3.56    bladder:- kidney:2.24 pituitary:- thyroid/parathyroid:1.80 adrenal gland:2.43 pancreas:- breast:2.86 salivary:-

Gene Information

IDs

Refseq ID NM_004557
Gene ID 4855
Unigene ID Hs.436100
Probe set ID 205247_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000204301
GTEx ID ENSG00000204301

Orthologous Gene

Mouse[1]  NM_010929
Rat [0]  

Chromosomal Region

HSCHR6_MHC_APD  [32,173,961  -  32,183,518]
HSCHR6_MHC_COX  [32,111,094  -  32,140,316]
HSCHR6_MHC_QBL  [32,120,241  -  32,149,468]
HSCHR6_MHC_MCF  [32,239,047  -  32,268,294]
6p21.32  [32,162,620  -  32,191,844]
HSCHR6_MHC_MANN  [32,202,044  -  32,231,292]
HSCHR6_MHC_SSTO  [32,169,488  -  32,198,715]

Gene Family (Interpro ID)

IPR001881  EGF-like calcium-binding
IPR000742  EGF-like, type 3

Link to Pubmed  (Pubmed ID)

7671825
7835890
8681805
9168133
9576833
9693032
10079256
10221902
10645000
10932176
11078798
11101851
11112321
11119607
11239712
11381257
11381258
11407996
11518718
11532344
11585921
11803454
11823422
11836628
11901359
11909975
12370315
12477932
12496471
12589427
12605097
12627456
12782960
12814948
12873802
14651518
14701863
14730600
14732589
14961038
14966150
15009827
15091315
15115916
15187023
15211628
15531924
15653273
15684396
16007227
16378929
16538185
16894623
16969274
17054719
17192952
17452726
17496152
17696940
17822320
17920003
18184405
18239137
18583979
18593923
18663143
19116923
19143814
19143821
19156168
19242354
19404845
19503073
19571808
19659809
19851445
20041166
20068161
20069356
20331378
20444726
20467438
20554499
20587610
20596622
20602615
20643108
20673877
20832056
21045140
21085055
21124806
21159651
21203870
21402876
21408207
21602525
21679465
21726900
21779181
21804548
21864059
22001063
22066479
22084425
22488909
22641179
22694956
22732452
23015403
23028341
23212060
23237809
23251661
23266558
23318300
23326239
23444212
23450325
23535732
23566281
23576639
23583980
23587900
23620142
23742774
23749167
23894747
24250222
24373503
24403446

Gene Ontology  (GO ID)

Biological Process

GO:0030154  cell differentiation
GO:0001709  cell fate determination
GO:0009790  embryonic development
GO:0001886  endothelial cell morphogenesis
GO:0010467  gene expression
GO:0030097  hemopoiesis
GO:0030879  mammary gland development
GO:0001763  morphogenesis of a branching structure
GO:0045596  negative regulation of cell differentiation
GO:0045602  negative regulation of endothelial cell differentiation
GO:0007220  Notch receptor processing
GO:0007219  Notch signaling pathway
GO:0001569  patterning of blood vessels
GO:0007221  positive regulation of transcription of Notch receptor target
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0006367  transcription initiation from RNA polymerase II promoter

Cellular Component

GO:0009986  cell surface
GO:0005829  cytosol
GO:0005789  endoplasmic reticulum membrane
GO:0005576  extracellular region
GO:0000139  Golgi membrane
GO:0005887  integral to plasma membrane
GO:0005654  nucleoplasm
GO:0005634  nucleus
GO:0005886  plasma membrane

Molecular Function

GO:0005509  calcium ion binding
GO:0005515  protein binding
GO:0046982  protein heterodimerization activity
GO:0004872  receptor activity