SIX homeobox 6

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Synonym

sine oculis homeobox homolog 6 (Drosophila), sine oculis homeobox (Drosophila) homolog 6, Sine oculis homeobox homolog 6, Homeodomain protein OPTX2, Six9, Homeobox protein SIX6, MCOPCT2, Optic homeobox 2, OPTX2, SIX9, SIX6

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:3.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:88.20 artery/aorta:- vein:- lymphnode:20.20 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:3.47 cerebellum:3.58 brain stem:3.57 corpus callosum/glia:3.45 pineal gland:- peripheral nerve:3.34 spine:3.31 retina:- eye:- artery/aorta:3.44 vein:3.67 lymphnode:3.28 peripheral blood:- spleen:3.29 thymus:3.34 bone marrow:3.49 adipose:3.52 bone:- skin:3.71
CAGE cerebrum:0.05 cerebellum:- brain stem:0 corpus callosum/glia:0.13 pineal gland:0.36 peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0 vein:0 lymphnode:0 peripheral blood:- spleen:0 thymus:0 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.05 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:3.37 placenta:3.38 prostate:3.28 ovary:3.35 testis:3.30 heart:3.53 muscle:3.79 esophagus:3.41 stomach:3.27 intestine:3.56 colon:3.58 liver/hepato:3.43 lung:3.36 bladder:- kidney:3.42 pituitary:6.78 thyroid/parathyroid:3.30 adrenal gland:3.37 pancreas:3.85 breast:3.38 salivary:3.62
CAGE uterus:0 placenta:0 prostate:0.08 ovary:0 testis:0.40 heart:0 muscle:0.51 esophagus:0 stomach:- intestine:0 colon:0     liver/hepato:0    lung:0 bladder:0 kidney:0 pituitary:3.99 thyroid/parathyroid:0 adrenal gland:- pancreas:0 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0.04 ovary:0 testis:0.09 heart:0 muscle:0.09 esophagus:- stomach:- intestine:- colon:0     liver/hepato:0        lung:0    bladder:- kidney:0 pituitary:- thyroid/parathyroid:0.07 adrenal gland:0 pancreas:- breast:0 salivary:-

Gene Information

IDs

Refseq ID NM_007374
Gene ID 4990
Unigene ID Hs.194756
Probe set ID 207250_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000184302
GTEx ID ENSG00000184302

Orthologous Gene

Mouse[1]  NM_011384
Rat[1]  NM_001108032

Chromosomal Region

14q23.1  [60,975,869  -  60,978,527]

Gene Family (Interpro ID)

IPR001356  Homeobox
IPR009057  Homeodomain-like
IPR012287  Homeodomain-related

Link to Pubmed  (Pubmed ID)

10381575
10512683
11493467
12441302
12477932
15266624
15505031
18029348
18293925
18666230
20057906
20211142
20301477
20301552
20881960
22419738
22505724
22570617
23396134

Gene Ontology  (GO ID)

Biological Process

GO:0009887  organ morphogenesis
GO:0007601  visual perception

Cellular Component

GO:0005634  nucleus

Molecular Function

GO:0043565  sequence-specific DNA binding
GO:0003700  transcription factor activity