paired box 6

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Synonym

MGDA, Aniridia type II protein, Paired box protein Pax-6, WAGR, MGC17209, Oculorhombin, D11S812E, AN2, paired box gene 6 (aniridia, keratitis), PAX6

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:- cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:-
GeneChip cerebrum:7.30 cerebellum:10.28 brain stem:7.20 corpus callosum/glia:7.98 pineal gland:- peripheral nerve:5.09 spine:7.90 retina:- eye:- artery/aorta:5.38 vein:5.67 lymphnode:4.98 peripheral blood:- spleen:4.78 thymus:4.97 bone marrow:5.06 adipose:5.27 bone:- skin:5.71
CAGE cerebrum:4.09 cerebellum:- brain stem:3.03 corpus callosum/glia:3.87 pineal gland:4.26 peripheral nerve:- spine:4.52 retina:- eye:- artery/aorta:1.16 vein:0.34 lymphnode:0.30 peripheral blood:- spleen:0 thymus:0.28 bone marrow:- adipose:0 bone:- skin:-
RNA-seq cerebrum:0.81 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.30 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.00 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:- prostate:- ovary:- testis:- heart:- muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:-    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:4.94 placenta:5.28 prostate:4.82 ovary:4.93 testis:5.91 heart:5.47 muscle:5.50 esophagus:5.36 stomach:5.81 intestine:5.82 colon:5.20 liver/hepato:5.45 lung:5.12 bladder:- kidney:5.25 pituitary:6.80 thyroid/parathyroid:4.84 adrenal gland:5.34 pancreas:6.57 breast:4.99 salivary:5.47
CAGE uterus:0.06 placenta:0 prostate:0 ovary:0.07 testis:0.43 heart:0.12 muscle:0.25 esophagus:0 stomach:- intestine:1.13 colon:0.84     liver/hepato:0    lung:0 bladder:0 kidney:0 pituitary:2.78 thyroid/parathyroid:0 adrenal gland:- pancreas:2.48 breast:0 salivary:0
RNA-seq uterus:- placenta:- prostate:0.42 ovary:0.76 testis:0.13 heart:0.28 muscle:0.11 esophagus:- stomach:- intestine:- colon:0.36     liver/hepato:0.17        lung:0.22    bladder:- kidney:0.53 pituitary:- thyroid/parathyroid:0.24 adrenal gland:0.55 pancreas:- breast:0.30 salivary:-

IDs

Refseq ID NM_001127612
Gene ID 5080
Unigene ID Hs.611376
Probe set ID 205646_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000007372
GTEx ID ENSG00000007372

Orthologous Gene

Mouse[6]  NM_013627
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

1302030
1345175
1684738
7065945
7550230
7666404
7668281
7698003
7757816
7909985
7951315
7958875
8111379
8162071
8364574
8640214
8889548
9056723
9138149
9147640
9281415
9482572
9538891
9792406
9856761
9931324
10234503
10346815
10359315
10441571
10506141
10610023
10747901
10955655
11036080
11069920
11309364
11350962
11358870
11756345
11850181
12043047
12107410
12107413
12324464
12325030
12477932
12552561
12710953
12721955
12731001
12789139
12868034
12923055
12953159
14702039
14872040
15066147
15079031
15086958
15143176
15389894
15489334
15629294
15659382
15677484
15735909
15757974
15889018
15918896
16098226
16115881
16303743
16344560
16407227
16511221
16543198
16582099
16604056
16637659
16675956
16712695
16785853
16803629
16873704
17031679
17148041
17202185
17251190
17291498
17318412
17415970
17417613
17485622
17568989
17595013
17653045
17679951
17893655
17896318
17898260
17901057
17908181
17947347
17948041
17982423
18029348
18070176
18241071
18243151
18273794
18332330
18334930
18393239
18421978
18440259
18467663
18593849
18595732
18616618
18754095
18766996
18776953
18973570
19034419
19124844
19142206
19218613
19414065
19607881
19650334
19651775
19686589
19790232
19793656
19806578
19806579
19862335
19898691
19907666
19917615
19948975
20054790
20074565
20301534
20301552
20308539
20360993
20379614
20396773
20413449
20467438
20523026
20577777
20592023
20621053
20664694
20713004
20801516
20806047
21084637
21092858
21169528
21271670
21321669
21348901
21353197
21397818
21421876
21524647
21589860
21617155
21633710
21655361
21691140
21697133
21710692
21816254
21850189
21904390
21922321
21935435
21944253
21948554
21985185
21988832
21997878
22025896
22103961
22146551
22171157
22171686
22344219
22361317
22392277
22393272
22393275
22447870
22509105
22550392
22561546
22583899
22621390
22809227
22815628
22860217
22893676
23044950
23146210
23211052
23213273
23660406
23734086
23931477
23970099
23990468
24078574
24143217
24185687
24290376
24637479

Gene Ontology  (GO ID)

Biological Process

GO:0048708  astrocyte differentiation
GO:0007411  axon guidance
GO:0001568  blood vessel development
GO:0001709  cell fate determination
GO:0007417  central nervous system development
GO:0021796  cerebral cortex regionalization
GO:0021902  commitment of a neuronal cell to a specific type of neuron in the forebrain
GO:0009950  dorsal/ventral axis specification
GO:0048596  embryonic camera-type eye morphogenesis
GO:0001654  eye development
GO:0042462  eye photoreceptor cell development
GO:0021797  forebrain anterior/posterior pattern formation
GO:0021798  forebrain dorsal/ventral pattern formation
GO:0021905  forebrain-midbrain boundary formation
GO:0042593  glucose homeostasis
GO:0030902  hindbrain development
GO:0030216  keratinocyte differentiation
GO:0032808  lacrimal gland development
GO:0002088  lens development in camera-type eye
GO:0050680  negative regulation of epithelial cell proliferation
GO:0050768  negative regulation of neurogenesis
GO:0045665  negative regulation of neuron differentiation
GO:0048663  neuron fate commitment
GO:0001764  neuron migration
GO:0021778  oligodendrocyte cell fate specification
GO:0009887  organ morphogenesis
GO:0003322  pancreatic A cell development
GO:0021983  pituitary gland development
GO:0042660  positive regulation of cell fate specification
GO:0030858  positive regulation of epithelial cell differentiation
GO:0010628  positive regulation of gene expression
GO:0002052  positive regulation of neuroblast proliferation
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0033365  protein localization in organelle
GO:0016567  protein ubiquitination
GO:0030334  regulation of cell migration
GO:0048505  regulation of timing of cell differentiation
GO:0021918  regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment
GO:0021912  regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification
GO:0021913  regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification
GO:0009611  response to wounding
GO:0007435  salivary gland morphogenesis
GO:0007224  smoothened signaling pathway
GO:0006366  transcription from RNA polymerase II promoter
GO:0007601  visual perception

Cellular Component

GO:0005737  cytoplasm
GO:0000790  nuclear chromatin
GO:0005730  nucleolus
GO:0005634  nucleus

Molecular Function

GO:0003680  AT DNA binding
GO:0070410  co-SMAD binding
GO:0003677  DNA binding
GO:0003690  double-stranded DNA binding
GO:0035035  histone acetyltransferase binding
GO:0005515  protein binding
GO:0019901  protein kinase binding
GO:0070412  R-SMAD binding
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding
GO:0031625  ubiquitin protein ligase binding
GO:0004842  ubiquitin-protein ligase activity