hydroxysteroid (17-beta) dehydrogenase 12

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Synonym

17-beta-HSD 12, KAR, hydroxysteroid (17-beta) dehydrogenase 12, 17-beta-hydroxysteroid dehydrogenase 12, 3-ketoacyl-CoA reductase, HSD17B12, Estradiol 17-beta-dehydrogenase 12

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:208.60 cerebellum:100.80 brain stem:- corpus callosum/glia:641.50 pineal gland:148.30 peripheral nerve:30.70 spine:- retina:- eye:76.40 artery/aorta:359.70 vein:66.60 lymphnode:50.60 peripheral blood:218.60 spleen:189.10 thymus:64.40 bone marrow:59 adipose:242 bone:294.30 skin:187.20
GeneChip cerebrum:9.08 cerebellum:8.37 brain stem:9.57 corpus callosum/glia:9.39 pineal gland:- peripheral nerve:9.84 spine:9.58 retina:- eye:- artery/aorta:9.11 vein:8.81 lymphnode:8.54 peripheral blood:- spleen:8.84 thymus:8.25 bone marrow:8.29 adipose:9.18 bone:- skin:8.76
CAGE cerebrum:4.35 cerebellum:- brain stem:4.84 corpus callosum/glia:4.68 pineal gland:4.97 peripheral nerve:- spine:4.66 retina:- eye:- artery/aorta:4.45 vein:4.06 lymphnode:4.12 peripheral blood:- spleen:4.35 thymus:3.80 bone marrow:- adipose:4.52 bone:- skin:-
RNA-seq cerebrum:5.77 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.79 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.84 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:218.70 placenta:47.40 prostate:169 ovary:111.80 testis:125.50 heart:51.10 muscle:- esophagus:342.80 stomach:85 intestine:486 colon:169.60     liver/hepato:84.40        lung:132    bladder:251.20 kidney:332.70 pituitary:232 thyroid/parathyroid:163.70 adrenal gland:253.90 pancreas:71.10 breast:83.60 salivary:-
GeneChip uterus:8.91 placenta:7.01 prostate:9.54 ovary:9.11 testis:8.53 heart:9.20 muscle:8.05 esophagus:9.07 stomach:9.22 intestine:8.70 colon:8.31 liver/hepato:9.33 lung:8.84 bladder:- kidney:9.34 pituitary:9.09 thyroid/parathyroid:9.34 adrenal gland:9.58 pancreas:8.87 breast:8.92 salivary:8.94
CAGE uterus:4.40 placenta:3.62 prostate:4.25 ovary:4.28 testis:4.30 heart:4.65 muscle:3.75 esophagus:4.39 stomach:- intestine:4.60 colon:4.39     liver/hepato:5.09    lung:4.57 bladder:4.19 kidney:4.83 pituitary:4.61 thyroid/parathyroid:4.38 adrenal gland:- pancreas:4.41 breast:4.67 salivary:4.60
RNA-seq uterus:- placenta:- prostate:5.10 ovary:5.15 testis:5.13 heart:4.60 muscle:3.52 esophagus:- stomach:- intestine:- colon:5.29     liver/hepato:6.14        lung:5.45    bladder:- kidney:5.57 pituitary:- thyroid/parathyroid:5.75 adrenal gland:4.88 pancreas:- breast:5.61 salivary:-

Gene Information

IDs

Refseq ID NM_016142
Gene ID 51144
Unigene ID Hs.132513
Probe set ID 217869_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000149084
GTEx ID ENSG00000149084

Orthologous Gene

Mouse[2]  NM_019657
Rat [0]  

Chromosomal Region

11p11.2  [43,577,986  -  43,878,167]

Gene Family (Interpro ID)

IPR002347  Glucose/ribitol dehydrogenase
IPR002198  Short-chain dehydrogenase/reductase SDR

Link to Pubmed  (Pubmed ID)

8125298
8944226
12477932
12482854
14702039
15342556
15489334
16113833
16166196
16196087
16621523
19027726
19190350
19429442
19460435
19533843
20562859
20677014
20937905
21139048
21409596
21890473
21906983
22190034
22678362
22797925
22903146
22941191
23246001
23435447
23464991
23752268
23798571
23956138
24058506
24163370
24457600
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0044255  cellular lipid metabolic process
GO:0006703  estrogen biosynthetic process
GO:0030198  extracellular matrix organization
GO:0006633  fatty acid biosynthetic process
GO:0010811  positive regulation of cell-substrate adhesion
GO:0019432  triglyceride biosynthetic process

Cellular Component

GO:0005789  endoplasmic reticulum membrane
GO:0031012  extracellular matrix
GO:0016021  integral to membrane

Molecular Function

GO:0005518  collagen binding
GO:0004303  estradiol 17-beta-dehydrogenase activity
GO:0001968  fibronectin binding
GO:0008201  heparin binding
GO:0005515  protein binding