phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)

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Synonym

PDE4D, cAMP-specific 3',5'-cyclic phosphodiesterase 4D, STRK1, PDE4DN2, DPDE3, PDE43, HSPDE4D

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:3.60

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:17.60

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:38.70

bone marrow:177.10

adipose:-

bone:-

skin:14.40

GeneChip

cerebrum:6.76

cerebellum:6.60

brain stem:6.88

corpus callosum/glia:5.75

pineal gland:-

peripheral nerve:6.71

spine:6.53

retina:-

eye:-

artery/aorta:6.53

vein:7.68

lymphnode:5.92

peripheral blood:-

spleen:5.91

thymus:6.58

bone marrow:6.29

adipose:5.95

bone:-

skin:5.80

CAGE

cerebrum:3.43

cerebellum:-

brain stem:3.19

corpus callosum/glia:2.74

pineal gland:4.92

peripheral nerve:-

spine:3.34

retina:-

eye:-

artery/aorta:4.02

vein:3.39

lymphnode:3.58

peripheral blood:-

spleen:2.87

thymus:3.28

bone marrow:-

adipose:3.73

bone:-

skin:-

RNA-seq

cerebrum:1.38

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.00

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.00

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:-

placenta:10.90

prostate:67.60

ovary:-

testis:4.30

heart:-

muscle:-

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:-

lung:68.40

bladder:-

kidney:20.80

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:-

salivary:-

GeneChip

uterus:6.63

placenta:5.98

prostate:7.59

ovary:6.15

testis:5.15

heart:7.37

muscle:8.55

esophagus:6.12

stomach:7

intestine:6.86

colon:6.65

liver/hepato:5.85

lung:6.67

bladder:-

kidney:6.77

pituitary:6.50

thyroid/parathyroid:6.42

adrenal gland:5.76

pancreas:6.12

breast:5.74

salivary:6.17

CAGE

uterus:4.59

placenta:3.18

prostate:4.76

ovary:3.56

testis:2.35

heart:4.37

muscle:5.64

esophagus:3.60

stomach:-

intestine:3.82

colon:4.10

liver/hepato:2.68

lung:4.15

bladder:4.87

kidney:3.42

pituitary:3.67

thyroid/parathyroid:3.03

adrenal gland:-

pancreas:2.41

breast:3.12

salivary:5.05

RNA-seq

uterus:-

placenta:-

prostate:1.00

ovary:0.00

testis:0.00

heart:0.00

muscle:4.67

esophagus:-

stomach:-

intestine:-

colon:0.07

liver/hepato:0.00

lung:1.97

bladder:-

kidney:1.68

pituitary:-

thyroid/parathyroid:2.02

adrenal gland:0.00

pancreas:-

breast:0.26

salivary:-

IDs

Refseq ID	NM_006203
Gene ID	5144
Unigene ID	Hs.526886
Probe set ID	204491_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000113448
GTEx ID	ENSG00000113448

Orthologous Gene

Mouse[1]	NM_011056
Rat[1]	NM_011056

Chromosomal Region

5q12.1 [58,264,865 - 59,817,947]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

Gene Ontology (GO ID)

Biological Process

GO:0007568	aging
GO:0006198	cAMP catabolic process
GO:0019933	cAMP-mediated signaling
GO:0071320	cellular response to cAMP
GO:0071222	cellular response to lipopolysaccharide
GO:0035264	multicellular organism growth
GO:0045822	negative regulation of heart contraction
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0030593	neutrophil chemotaxis
GO:0032729	positive regulation of interferon-gamma production
GO:0032743	positive regulation of interleukin-2 production
GO:0032754	positive regulation of interleukin-5 production
GO:0002027	regulation of heart rate
GO:0010469	regulation of receptor activity
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0060314	regulation of ryanodine-sensitive calcium-release channel activity
GO:0006939	smooth muscle contraction
GO:0050852	T cell receptor signaling pathway

Cellular Component

GO:0034704	calcium channel complex
GO:0005829	cytosol
GO:0016020	membrane
GO:0005815	microtubule organizing center
GO:0005891	voltage-gated calcium channel complex

Molecular Function

GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0051117	ATPase binding
GO:0031698	beta-2 adrenergic receptor binding
GO:0030552	cAMP binding
GO:0008144	drug binding
GO:0019899	enzyme binding
GO:0046872	metal ion binding
GO:0031625	ubiquitin protein ligase binding

phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function