platelet-derived growth factor alpha polypeptide

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Synonym

PDGF-A, platelet-derived growth factor alpha polypeptide, PDGFA, Platelet-derived growth factor alpha polypeptide, Platelet-derived growth factor A chain precursor, PDGF1, PDGF-1, PDGF A-chain

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:1.20 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:224.60 retina:118.60 eye:17.60 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:9.60
GeneChip cerebrum:5.60 cerebellum:4.81 brain stem:5.73 corpus callosum/glia:5.98 pineal gland:- peripheral nerve:5.39 spine:5.81 retina:- eye:- artery/aorta:6.48 vein:5.96 lymphnode:5.10 peripheral blood:- spleen:5.39 thymus:4.70 bone marrow:4.61 adipose:5.07 bone:- skin:5.15
CAGE cerebrum:3.77 cerebellum:- brain stem:4.31 corpus callosum/glia:4.66 pineal gland:3.11 peripheral nerve:- spine:4.46 retina:- eye:- artery/aorta:5.19 vein:3.32 lymphnode:2.86 peripheral blood:- spleen:3.59 thymus:1.93 bone marrow:- adipose:2.93 bone:- skin:-
RNA-seq cerebrum:0.07 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.53 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0.00 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:3.60 prostate:11.30 ovary:- testis:8.70 heart:25.50 muscle:- esophagus:- stomach:- intestine:- colon:17     liver/hepato:10.60        lung:9.80    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:8.90 breast:9.30 salivary:-
GeneChip uterus:5.04 placenta:4.87 prostate:6.16 ovary:4.89 testis:4.77 heart:5.39 muscle:5.39 esophagus:5.14 stomach:6.03 intestine:5.34 colon:5.08 liver/hepato:4.82 lung:5.57 bladder:- kidney:5.80 pituitary:5.24 thyroid/parathyroid:5.17 adrenal gland:5.33 pancreas:6.02 breast:5.52 salivary:6.19
CAGE uterus:3.61 placenta:3.20 prostate:3.52 ovary:3.14 testis:2.56 heart:3.69 muscle:2.46 esophagus:3.37 stomach:- intestine:3.84 colon:3.84     liver/hepato:2.82    lung:3.91 bladder:3.56 kidney:3.18 pituitary:2.30 thyroid/parathyroid:2.64 adrenal gland:- pancreas:4.13 breast:4.04 salivary:3.80
RNA-seq uterus:- placenta:- prostate:1.72 ovary:0.60 testis:0.08 heart:0.07 muscle:0.44 esophagus:- stomach:- intestine:- colon:0.41     liver/hepato:0.10        lung:1.34    bladder:- kidney:1.82 pituitary:- thyroid/parathyroid:0.06 adrenal gland:1.04 pancreas:- breast:0.39 salivary:-

Gene Information

IDs

Refseq ID NM_002607
Gene ID 5154
Unigene ID Hs.535898
Probe set ID 216867_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000197461
GTEx ID ENSG00000197461

Orthologous Gene

Mouse[2]  NM_008808
Rat [0]  

Chromosomal Region

7p22.3  [536,895  -  559,933]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

287022
291037
612586
1281549
1311092
1317862
1360804
1505216
1512241
1612586
1848007
1997274
2315311
2439522
2536956
2538439
2544881
2832727
2836953
2842868
3422746
3614363
3614364
3666150
3754619
7073684
7679113
8443409
8486521
8647855
8780057
8900172
9409235
9692901
9739761
9837894
10358027
10508235
10598812
10681572
10806482
11678848
11788434
11994382
12070119
12411321
12477932
12576295
12615918
12645527
12670444
12670890
12850832
12972619
14573617
14633628
14705808
14708943
14997209
15631865
15829977
15890262
16344560
16462734
16760468
16850112
17087110
17470632
17578349
17852407
17933214
17944929
17958740
17984069
18084257
18174235
18284546
18326546
18332228
18592007
18808740
18814141
18992915
19019919
19141566
19493486
19559929
19707201
19956642
20036812
20036815
20083221
20202860
20220555
20224347
20485444
20534510
20730440
20822908
21187969
21559523
21645144
21769672
21771201
21906875
21919032
21931722
21993555
22174424
22266848
22393407
22588000
22617683
22704695
22733151
22949635
22964636
23025904
23536282
23620752
24454980

Gene Ontology  (GO ID)

Biological Process

GO:0030036  actin cytoskeleton organization
GO:0001525  angiogenesis
GO:0007596  blood coagulation
GO:0001775  cell activation
GO:0030031  cell projection assembly
GO:0007267  cell-cell signaling
GO:0009790  embryonic development
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0030198  extracellular matrix organization
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0001942  hair follicle development
GO:0045087  innate immune response
GO:0048839  inner ear development
GO:0048286  lung alveolus development
GO:0050919  negative chemotaxis
GO:0010512  negative regulation of phosphatidylinositol biosynthetic process
GO:0010544  negative regulation of platelet activation
GO:0048011  nerve growth factor receptor signaling pathway
GO:0009887  organ morphogenesis
GO:0048015  phosphoinositide-mediated signaling
GO:0030168  platelet activation
GO:0002576  platelet degranulation
GO:0048008  platelet-derived growth factor receptor signaling pathway
GO:0051781  positive regulation of cell division
GO:0030335  positive regulation of cell migration
GO:0008284  positive regulation of cell proliferation
GO:0045740  positive regulation of DNA replication
GO:0070374  positive regulation of ERK1 and ERK2 cascade
GO:0048146  positive regulation of fibroblast proliferation
GO:0043406  positive regulation of MAP kinase activity
GO:0043410  positive regulation of MAPKKK cascade
GO:0002053  positive regulation of mesenchymal cell proliferation
GO:0014068  positive regulation of phosphoinositide 3-kinase cascade
GO:0031954  positive regulation of protein amino acid autophosphorylation
GO:0051897  positive regulation of protein kinase B signaling cascade
GO:0032956  regulation of actin cytoskeleton organization
GO:0060683  regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling
GO:0050730  regulation of peptidyl-tyrosine phosphorylation
GO:0014910  regulation of smooth muscle cell migration
GO:0042493  response to drug
GO:0032355  response to estradiol stimulus
GO:0001666  response to hypoxia
GO:0010035  response to inorganic substance
GO:0032526  response to retinoic acid
GO:0009611  response to wounding
GO:0043588  skin development
GO:0007179  transforming growth factor beta receptor signaling pathway
GO:0042060  wound healing

Cellular Component

GO:0009986  cell surface
GO:0005788  endoplasmic reticulum lumen
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0000139  Golgi membrane
GO:0005902  microvillus
GO:0031093  platelet alpha granule lumen

Molecular Function

GO:0005518  collagen binding
GO:0008083  growth factor activity
GO:0048407  platelet-derived growth factor binding
GO:0005161  platelet-derived growth factor receptor binding
GO:0046982  protein heterodimerization activity
GO:0042803  protein homodimerization activity