ectonucleotide pyrophosphatase/phosphodiesterase 1

Synonym

ENPP1, PCA1, PDNP1, M6S1, Phosphodiesterase I/nucleotide pyrophosphatase 1, ectonucleotide pyrophosphatase/phosphodiesterase 1, E-NPP 1, PC1, Ectonucleotide pyrophosphatase/phosphodiesterase 1, Plasma-cell membrane glycoprotein PC-1, NPPS, NPP1, PC-1

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:8.30

cerebellum:-

brain stem:-

corpus callosum/glia:87.50

pineal gland:-

peripheral nerve:92

spine:-

retina:-

eye:23.50

artery/aorta:-

vein:-

lymphnode:10.10

peripheral blood:18.20

spleen:-

thymus:12.90

bone marrow:-

adipose:40.30

bone:38.40

skin:24

GeneChip

cerebrum:4.47

cerebellum:4.27

brain stem:4.94

corpus callosum/glia:4.65

pineal gland:-

peripheral nerve:5.75

spine:5.07

retina:-

eye:-

artery/aorta:6.02

vein:5.58

lymphnode:5.07

peripheral blood:-

spleen:4.78

thymus:5.80

bone marrow:4.63

adipose:5.96

bone:-

skin:5.21

CAGE

cerebrum:0.40

cerebellum:-

brain stem:0.96

corpus callosum/glia:1.36

pineal gland:1.49

peripheral nerve:-

spine:1.25

retina:-

eye:-

artery/aorta:3.33

vein:1.53

lymphnode:0.82

peripheral blood:-

spleen:1.02

thymus:1.36

bone marrow:-

adipose:3.35

bone:-

skin:-

RNA-seq

cerebrum:0.20

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:1.07

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:3.55

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:100.20

placenta:98.40

prostate:-

ovary:37.30

testis:21.60

heart:25.50

muscle:-

esophagus:-

stomach:63.70

intestine:-

colon:25.40

liver/hepato:42.20

lung:19.60

bladder:-

kidney:83.20

pituitary:116

thyroid/parathyroid:163.70

adrenal gland:50.80

pancreas:8.90

breast:37.20

salivary:-

GeneChip

uterus:6.94

placenta:8.51

prostate:5.93

ovary:6.49

testis:5.19

heart:5.17

muscle:5.38

esophagus:4.82

stomach:5.43

intestine:5.42

colon:5.13

liver/hepato:8.84

lung:5.18

bladder:-

kidney:6.06

pituitary:7.21

thyroid/parathyroid:8.78

adrenal gland:5.63

pancreas:6.87

breast:6.45

salivary:5.85

CAGE

uterus:3.24

placenta:3.72

prostate:1.89

ovary:2.46

testis:1.94

heart:1.35

muscle:1.56

esophagus:1.34

stomach:-

intestine:1.67

colon:1.91

liver/hepato:2.98

lung:1.39

bladder:1.80

kidney:2.83

pituitary:3.87

thyroid/parathyroid:2.99

adrenal gland:-

pancreas:2.41

breast:3.87

salivary:2.22

RNA-seq

uterus:-

placenta:-

prostate:1.79

ovary:2.01

testis:2.80

heart:0.80

muscle:0.86

esophagus:-

stomach:-

intestine:-

colon:0.99

liver/hepato:3.22

lung:0.85

bladder:-

kidney:2.24

pituitary:-

thyroid/parathyroid:3.74

adrenal gland:1.29

pancreas:-

breast:3.44

salivary:-

IDs

Refseq ID	NM_006208
Gene ID	5167
Unigene ID	Hs.527295
Probe set ID	205066_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000197594
GTEx ID	ENSG00000197594

Orthologous Gene

Mouse[2]	NM_008813
Rat [0]

Chromosomal Region

6q23.2 [132,129,156 - 132,216,295]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR001604	DNA/RNA non-specific endonuclease
IPR020821	Extracellular Endonuclease, subunit A
IPR001212	Somatomedin B
IPR020436	Somatomedin B, chordata

Gene Ontology (GO ID)

Biological Process

GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process
GO:0031214	biomineral formation
GO:0046849	bone remodeling
GO:0030643	cellular phosphate ion homeostasis
GO:0032869	cellular response to insulin stimulus
GO:0006091	generation of precursor metabolites and energy
GO:0006955	immune response
GO:0030505	inorganic diphosphate transport
GO:0030308	negative regulation of cell growth
GO:0045599	negative regulation of fat cell differentiation
GO:0046325	negative regulation of glucose import
GO:0045719	negative regulation of glycogen biosynthetic process
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0030279	negative regulation of ossification
GO:0031953	negative regulation of protein amino acid autophosphorylation
GO:0009143	nucleoside triphosphate catabolic process
GO:0006796	phosphate metabolic process
GO:0030500	regulation of bone mineralization
GO:0006771	riboflavin metabolic process
GO:0030730	sequestering of triglyceride
GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process

Cellular Component

GO:0016323	basolateral plasma membrane
GO:0009986	cell surface
GO:0005615	extracellular space
GO:0016021	integral to membrane
GO:0005886	plasma membrane

Molecular Function

GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding
GO:0005524	ATP binding
GO:0005158	insulin receptor binding
GO:0046872	metal ion binding
GO:0003676	nucleic acid binding
GO:0047429	nucleoside-triphosphate diphosphatase activity
GO:0004551	nucleotide diphosphatase activity
GO:0004528	phosphodiesterase I activity
GO:0030247	polysaccharide binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0005044	scavenger receptor activity

ectonucleotide pyrophosphatase/phosphodiesterase 1

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function