phosphoinositide-3-kinase, catalytic, delta polypeptide

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Synonym

PIK3CD, PI3-kinase p110 subunit delta, p110D, p110delta

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:15.40 cerebellum:- brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:- spine:- retina:- eye:47 artery/aorta:30 vein:133.30 lymphnode:141.50 peripheral blood:109.30 spleen:170.20 thymus:77.30 bone marrow:157.40 adipose:- bone:25.60 skin:28.80
GeneChip cerebrum:6.31 cerebellum:6.07 brain stem:6.31 corpus callosum/glia:6.41 pineal gland:- peripheral nerve:6.57 spine:6.25 retina:- eye:- artery/aorta:6.64 vein:6.21 lymphnode:8.75 peripheral blood:- spleen:9.27 thymus:8.44 bone marrow:8.87 adipose:6.74 bone:- skin:6.21
CAGE cerebrum:1.57 cerebellum:- brain stem:2.18 corpus callosum/glia:2.38 pineal gland:0.86 peripheral nerve:- spine:2.09 retina:- eye:- artery/aorta:2.17 vein:3.91 lymphnode:4.15 peripheral blood:- spleen:3.99 thymus:3.53 bone marrow:- adipose:1.76 bone:- skin:-
RNA-seq cerebrum:1.04 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.58 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.26 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:36.50 placenta:- prostate:11.30 ovary:- testis:38.90 heart:12.80 muscle:- esophagus:- stomach:21.20 intestine:- colon:67.80     liver/hepato:10.60        lung:29.30    bladder:- kidney:62.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:8.90 breast:55.80 salivary:-
GeneChip uterus:6.42 placenta:5.98 prostate:6.10 ovary:6.72 testis:6.39 heart:6 muscle:5.43 esophagus:6.29 stomach:6.74 intestine:6.42 colon:6.54 liver/hepato:6.42 lung:7.43 bladder:- kidney:6.62 pituitary:5.93 thyroid/parathyroid:6.64 adrenal gland:6.24 pancreas:6.33 breast:6.72 salivary:6.33
CAGE uterus:1.69 placenta:1.90 prostate:1.86 ovary:1.44 testis:1.83 heart:1.59 muscle:0.52 esophagus:1.86 stomach:- intestine:2.17 colon:2.26     liver/hepato:1.76    lung:2.73 bladder:1.45 kidney:1.38 pituitary:0.86 thyroid/parathyroid:1.17 adrenal gland:- pancreas:0.58 breast:1.36 salivary:2.06
RNA-seq uterus:- placenta:- prostate:1.63 ovary:1.28 testis:1.65 heart:0.68 muscle:0.34 esophagus:- stomach:- intestine:- colon:1.31     liver/hepato:0.53        lung:2.49    bladder:- kidney:1.20 pituitary:- thyroid/parathyroid:0.88 adrenal gland:3.81 pancreas:- breast:1.23 salivary:-

Gene Information

IDs

Refseq ID NM_005026
Gene ID 5293
Unigene ID Hs.518451
Probe set ID 203879_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000171608
GTEx ID ENSG00000171608

Orthologous Gene

Mouse[18]  NM_001029837, NM_001164049, NM_001164050, NM_001164051, NM_001164052, NM_008840
Rat[1]  NM_001108978, NM_001164049, NM_001164050, NM_001164051, NM_001164052, NM_008840

Chromosomal Region

1p36.22  [9,711,790  -  9,789,172]

Gene Family (Interpro ID)

IPR016024  Armadillo-type fold
IPR008973  C2 calcium/lipid-binding domain, CaLB
IPR000403  Phosphatidylinositol 3-/4-kinase, catalytic
IPR001263  Phosphoinositide 3-kinase, accessory (PIK) domain
IPR002420  Phosphoinositide 3-kinase, C2
IPR011009  Protein kinase-like domain

Link to Pubmed  (Pubmed ID)

8636073
8798481
8889549
9113989
9235916
9247029
9341793
9394803
9446795
9455486
9708406
9808187
10064595
10208934
10922060
10949031
10985305
11154208
11156964
11289809
11739523
11994280
12077252
12477932
12526811
12551992
12584329
12594293
12774123
12960231
14602571
15146197
15689238
15840695
15878979
16081599
16169070
16432180
16524887
16984281
17015696
17157319
17290298
17474147
17581634
17632516
17632570
18281552
18348712
18453587
18471882
18854243
18996102
19357769
19380743
19638627
19843950
19913121
20019835
20041213
20056178
20081091
20103642
20189103
20197460
20381852
20534549
20602615
20628086
20702582
20818790
20837746
21029719
21765914
21810603
21890473
21906983
22015454
22020336
22079609
22084313
22210877
22375552
22433439
22689948
22711705
22798525
23077641
23215766
23251686
23301033
23341541
23486085
23660190
24073214
24136356
24165795
24293274
24470496
24517182
24553178

Gene Ontology  (GO ID)

Biological Process

GO:0002250  adaptive immune response
GO:0042113  B cell activation
GO:0001782  B cell homeostasis
GO:0050853  B cell receptor signaling pathway
GO:0001816  cytokine production
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0006954  inflammatory response
GO:0045087  innate immune response
GO:0002551  mast cell chemotaxis
GO:0043303  mast cell degranulation
GO:0060374  mast cell differentiation
GO:0030101  natural killer cell activation
GO:0001779  natural killer cell differentiation
GO:0048011  nerve growth factor receptor signaling pathway
GO:0030593  neutrophil chemotaxis
GO:0006661  phosphatidylinositol biosynthetic process
GO:0014065  phosphoinositide 3-kinase cascade
GO:0048015  phosphoinositide-mediated signaling
GO:0006644  phospholipid metabolic process
GO:0006468  protein amino acid phosphorylation
GO:0002679  respiratory burst during defense response
GO:0007165  signal transduction
GO:0042110  T cell activation
GO:0010818  T cell chemotaxis
GO:0030217  T cell differentiation
GO:0050852  T cell receptor signaling pathway

Cellular Component

GO:0005829  cytosol
GO:0005942  phosphoinositide 3-kinase complex
GO:0005886  plasma membrane

Molecular Function

GO:0016303  1-phosphatidylinositol-3-kinase activity
GO:0005524  ATP binding
GO:0046934  phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0035005  phosphatidylinositol-4-phosphate 3-kinase activity
GO:0035004  phosphoinositide 3-kinase activity
GO:0005515  protein binding