paired-like homeodomain 2

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Synonym

RIEG bicoid-related homeobox transcription factor, PITX2, paired-like homeodomain transcription factor 2, ALL1-responsive protein ARP1, Pituitary homeobox 2, MGC111022, IGDS, IDG2, RIEG, IGDS2, PTX2, Brx1, IHG2, RIEG1, IRID2, RGS, Otlx2, Solurshin, MGC20144

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:3.60 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:129.30 artery/aorta:- vein:66.60 lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:43.20
GeneChip cerebrum:2.75 cerebellum:2.71 brain stem:2.66 corpus callosum/glia:2.55 pineal gland:- peripheral nerve:2.58 spine:2.54 retina:- eye:- artery/aorta:2.67 vein:2.76 lymphnode:2.55 peripheral blood:- spleen:2.45 thymus:2.42 bone marrow:2.68 adipose:3.08 bone:- skin:2.86
CAGE cerebrum:0.01 cerebellum:- brain stem:0.13 corpus callosum/glia:0 pineal gland:0 peripheral nerve:- spine:0 retina:- eye:- artery/aorta:0 vein:0.47 lymphnode:0.35 peripheral blood:- spleen:0 thymus:0.06 bone marrow:- adipose:0.90 bone:- skin:-
RNA-seq cerebrum:0 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.03 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:0 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:156.70 prostate:- ovary:- testis:4.30 heart:12.80 muscle:20.10 esophagus:- stomach:- intestine:32.40 colon:17     liver/hepato:10.60        lung:-    bladder:- kidney:10.40 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:- salivary:-
GeneChip uterus:2.61 placenta:6.57 prostate:2.68 ovary:2.61 testis:2.64 heart:3.08 muscle:6.53 esophagus:5.10 stomach:2.63 intestine:3.90 colon:4.04 liver/hepato:2.51 lung:2.50 bladder:- kidney:2.67 pituitary:5.36 thyroid/parathyroid:2.52 adrenal gland:2.57 pancreas:3.02 breast:2.70 salivary:2.59
CAGE uterus:0.51 placenta:2.99 prostate:2.86 ovary:0.14 testis:0.32 heart:0.80 muscle:2.74 esophagus:1.85 stomach:- intestine:1.96 colon:1.93     liver/hepato:0    lung:0.17 bladder:3.26 kidney:0.49 pituitary:2.86 thyroid/parathyroid:0.28 adrenal gland:- pancreas:0 breast:0.55 salivary:0
RNA-seq uterus:- placenta:- prostate:2.49 ovary:0 testis:0.43 heart:0.02 muscle:2.69 esophagus:- stomach:- intestine:- colon:0     liver/hepato:0        lung:0    bladder:- kidney:0.15 pituitary:- thyroid/parathyroid:0.94 adrenal gland:0 pancreas:- breast:0.43 salivary:-

Gene Information

IDs

Refseq ID NM_000325
Gene ID 5308
Unigene ID Hs.643588
Probe set ID 207558_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000164093
GTEx ID ENSG00000164093

Orthologous Gene

Mouse[5]  NM_001042502, NM_001042504, NM_011098
Rat [0]  

Chromosomal Region

4q25  [111,538,579  -  111,563,279]

Gene Family (Interpro ID)

IPR001356  Homeobox
IPR009057  Homeodomain-like
IPR012287  Homeodomain-related

Link to Pubmed  (Pubmed ID)

1303248
7581385
8942889
8944018
9437321
9539779
9618168
9685346
9708732
10051017
10372733
11157981
11487566
11763998
11774072
11821690
11948188
12130547
12223489
12381896
12464179
12477932
12612071
12732450
14630904
14975719
14985297
15255117
15342556
15385555
15466416
15489334
15591271
15728254
15895993
16274491
16449236
16498627
16638984
16834779
16876867
16884686
16936096
17065505
17167399
17197537
17486624
17558846
17603472
17850355
17965955
18312615
18331556
18339718
18616618
18711169
18775326
18946986
19052653
19174163
19218601
19233404
19251162
19513095
19597492
19801652
19913121
19954729
20022124
20170812
20173747
20211142
20301552
20332099
20372070
20478579
20628086
20634891
20875405
20881290
20881294
20978111
21221769
21278591
21282332
21414601
21427120
21479692
21498098
21511879
21531708
21574119
21617755
21803613
21810944
21837767
22224469
22495974
22544366
22555092
22569110
22615897
22735262
23041239
23042660
23088713
23132660
23229549
23354914
23505501
23913021
23983605
24003428
24083357
24162257
24250222
24262325
24486544

Gene Ontology  (GO ID)

Biological Process

GO:0055009  atrial cardiac muscle tissue morphogenesis
GO:0003171  atrioventricular valve development
GO:0043010  camera-type eye development
GO:0003253  cardiac neural crest cell migration involved in outflow tract morphogenesis
GO:0007368  determination of left/right symmetry
GO:0031076  embryonic camera-type eye development
GO:0048557  embryonic digestive tract morphogenesis
GO:0035116  embryonic hindlimb morphogenesis
GO:0002074  extraocular skeletal muscle development
GO:0008585  female gonad development
GO:0035315  hair cell differentiation
GO:0021855  hypothalamus cell migration
GO:0001701  in utero embryonic development
GO:0060460  left lung morphogenesis
GO:0070986  left/right axis specification
GO:0008584  male gonad development
GO:0007520  myoblast fusion
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0001764  neuron migration
GO:0042476  odontogenesis
GO:0042475  odontogenesis of dentine-containing tooth
GO:0001569  patterning of blood vessels
GO:0043388  positive regulation of DNA binding
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0060127  prolactin secreting cell differentiation
GO:0003350  pulmonary myocardium development
GO:0060577  pulmonary vein morphogenesis
GO:0030334  regulation of cell migration
GO:0006355  regulation of transcription, DNA-dependent
GO:0009725  response to hormone stimulus
GO:0033189  response to vitamin A
GO:0060126  somatotropin secreting cell differentiation
GO:0048536  spleen development
GO:0021763  subthalamic nucleus development
GO:0060578  superior vena cava morphogenesis
GO:0001570  vasculogenesis
GO:0055015  ventricular cardiac muscle cell development
GO:0060412  ventricular septum morphogenesis
GO:0016055  Wnt receptor signaling pathway

Cellular Component

GO:0005737  cytoplasm
GO:0005634  nucleus
GO:0005667  transcription factor complex

Molecular Function

GO:0031490  chromatin DNA binding
GO:0051219  phosphoprotein binding
GO:0005515  protein binding
GO:0042803  protein homodimerization activity
GO:0043021  ribonucleoprotein binding
GO:0003700  transcription factor activity
GO:0008134  transcription factor binding