peroxisome proliferator-activated receptor gamma

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Synonym

NR1C3, peroxisome proliferator-activated receptor gamma, PPARG2, PPAR-gamma, PPARG1, Peroxisome proliferator-activated receptor gamma, PPARG

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:10.70 cerebellum:- brain stem:- corpus callosum/glia:29.20 pineal gland:- peripheral nerve:61.30 spine:336.90 retina:- eye:- artery/aorta:- vein:- lymphnode:- peripheral blood:18.20 spleen:37.80 thymus:- bone marrow:19.70 adipose:80.70 bone:38.40 skin:24
GeneChip cerebrum:4.34 cerebellum:4.44 brain stem:4.26 corpus callosum/glia:4.31 pineal gland:- peripheral nerve:4.47 spine:4.26 retina:- eye:- artery/aorta:5.60 vein:4.80 lymphnode:4.63 peripheral blood:- spleen:4.67 thymus:4.10 bone marrow:4.72 adipose:8.32 bone:- skin:5.91
CAGE cerebrum:0.83 cerebellum:- brain stem:0.95 corpus callosum/glia:1.08 pineal gland:0.43 peripheral nerve:- spine:1.34 retina:- eye:- artery/aorta:2.78 vein:4.08 lymphnode:2.55 peripheral blood:- spleen:2.90 thymus:1.03 bone marrow:- adipose:5.58 bone:- skin:-
RNA-seq cerebrum:0 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.00 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:2.99 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:- placenta:98.40 prostate:33.80 ovary:298.10 testis:13 heart:12.80 muscle:- esophagus:- stomach:21.20 intestine:32.40 colon:161.10     liver/hepato:-        lung:48.90    bladder:- kidney:52 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:46.50 salivary:-
GeneChip uterus:4.70 placenta:6.73 prostate:4.89 ovary:5.28 testis:4.76 heart:5.48 muscle:4.92 esophagus:4.94 stomach:5.45 intestine:4.77 colon:6.29 liver/hepato:4.63 lung:6.87 bladder:- kidney:5.07 pituitary:4.03 thyroid/parathyroid:5.09 adrenal gland:4.56 pancreas:4.92 breast:6.15 salivary:4.42
CAGE uterus:2.26 placenta:4.17 prostate:3.38 ovary:2.55 testis:2.36 heart:3.39 muscle:2.39 esophagus:2.11 stomach:- intestine:3.17 colon:4.29     liver/hepato:2.31    lung:4.16 bladder:4.40 kidney:2.81 pituitary:0.34 thyroid/parathyroid:2.23 adrenal gland:- pancreas:1.21 breast:5.58 salivary:1.75
RNA-seq uterus:- placenta:- prostate:2.45 ovary:0.82 testis:1.22 heart:1.74 muscle:0 esophagus:- stomach:- intestine:- colon:0.09     liver/hepato:0.00        lung:1.84    bladder:- kidney:0.99 pituitary:- thyroid/parathyroid:1.81 adrenal gland:1.08 pancreas:- breast:3.51 salivary:-

IDs

Refseq ID NM_138711
Gene ID 5468
Unigene ID Hs.162646
Probe set ID 208510_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000132170
GTEx ID ENSG00000132170

Orthologous Gene

Mouse[2]  NM_001127330, NM_011146
Rat[3]  NM_001145366, NM_001145367, NM_013124

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

1504714
7787419
7838715
8001151
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8702406
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9041124
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24126791
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24308220
24319114
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24333565
24359430
24371122
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24379269
24431460
24440556
24447396
24510380
24569375
24623782
24642257
24779289
24839816

Gene Ontology  (GO ID)

Biological Process

GO:0006919  activation of caspase activity
GO:0050873  brown fat cell differentiation
GO:0045165  cell fate commitment
GO:0048469  cell maturation
GO:0032869  cellular response to insulin stimulus
GO:0071285  cellular response to lithium ion
GO:0030855  epithelial cell differentiation
GO:0019395  fatty acid oxidation
GO:0010467  gene expression
GO:0042593  glucose homeostasis
GO:0007507  heart development
GO:0045087  innate immune response
GO:0055088  lipid homeostasis
GO:0006629  lipid metabolic process
GO:0042953  lipoprotein transport
GO:0015909  long-chain fatty acid transport
GO:0045713  low-density lipoprotein receptor biosynthetic process
GO:0030224  monocyte differentiation
GO:0002674  negative regulation of acute inflammatory response
GO:0030308  negative regulation of cell growth
GO:0010887  negative regulation of cholesterol storage
GO:0060336  negative regulation of interferon-gamma-mediated signaling pathway
GO:0010745  negative regulation of macrophage derived foam cell differentiation
GO:0010871  negative regulation of receptor biosynthetic process
GO:0010891  negative regulation of sequestering of triglyceride
GO:0048662  negative regulation of smooth muscle cell proliferation
GO:0051974  negative regulation of telomerase activity
GO:0000122  negative regulation of transcription from RNA polymerase II promoter
GO:0045892  negative regulation of transcription, DNA-dependent
GO:0031100  organ regeneration
GO:0001890  placenta development
GO:0045600  positive regulation of fat cell differentiation
GO:0046321  positive regulation of fatty acid oxidation
GO:0048714  positive regulation of oligodendrocyte differentiation
GO:0051091  positive regulation of transcription factor activity
GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0045893  positive regulation of transcription, DNA-dependent
GO:0008217  regulation of blood pressure
GO:0060694  regulation of cholesterol transporter activity
GO:0031000  response to caffeine
GO:0009409  response to cold
GO:0042493  response to drug
GO:0043627  response to estrogen stimulus
GO:0033993  response to lipid
GO:0055098  response to low-density lipoprotein stimulus
GO:0007584  response to nutrient
GO:0032526  response to retinoic acid
GO:0033189  response to vitamin A
GO:0007165  signal transduction
GO:0006367  transcription initiation from RNA polymerase II promoter
GO:0050872  white fat cell differentiation

Cellular Component

GO:0005829  cytosol
GO:0005654  nucleoplasm
GO:0005634  nucleus

Molecular Function

GO:0050544  arachidonic acid binding
GO:0003682  chromatin binding
GO:0003677  DNA binding
GO:0044212  DNA regulatory region binding
GO:0008144  drug binding
GO:0019899  enzyme binding
GO:0004879  ligand-dependent nuclear receptor activity
GO:0030374  ligand-dependent nuclear receptor transcription coactivator activity
GO:0004955  prostaglandin receptor activity
GO:0005515  protein binding
GO:0046965  retinoid X receptor binding
GO:0043565  sequence-specific DNA binding
GO:0003707  steroid hormone receptor activity
GO:0033613  transcription activator binding
GO:0003700  transcription factor activity
GO:0008270  zinc ion binding