trimethyllysine hydroxylase, epsilon

 jump to detail

Synonym

FLJ10727, BBOX2, XAP130, Epsilon-trimethyllysine 2-oxoglutarate dioxygenase, TMLD, TMLH, trimethyllysine hydroxylase, epsilon, TML dioxygenase, TML-alpha-ketoglutarate dioxygenase, TMLHE, TML hydroxylase

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:23.70 cerebellum:25.20 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:11.80 artery/aorta:- vein:- lymphnode:30.30 peripheral blood:- spleen:- thymus:38.70 bone marrow:98.40 adipose:- bone:- skin:14.40
GeneChip cerebrum:4.40 cerebellum:4.45 brain stem:4.36 corpus callosum/glia:4.46 pineal gland:- peripheral nerve:4.33 spine:4.64 retina:- eye:- artery/aorta:4.30 vein:4.35 lymphnode:4.04 peripheral blood:- spleen:4.05 thymus:3.95 bone marrow:4.36 adipose:4.31 bone:- skin:4.17
CAGE cerebrum:2.29 cerebellum:- brain stem:2.33 corpus callosum/glia:2.21 pineal gland:2.57 peripheral nerve:- spine:2.30 retina:- eye:- artery/aorta:2.28 vein:2.01 lymphnode:2.33 peripheral blood:- spleen:2.06 thymus:2.22 bone marrow:- adipose:1.84 bone:- skin:-
RNA-seq cerebrum:2.23 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:0.89 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.49 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:36.50 placenta:14.60 prostate:11.30 ovary:74.50 testis:8.70 heart:- muscle:40.20 esophagus:- stomach:42.50 intestine:- colon:17     liver/hepato:10.60        lung:9.80    bladder:- kidney:31.20 pituitary:- thyroid/parathyroid:- adrenal gland:- pancreas:- breast:9.30 salivary:-
GeneChip uterus:4.18 placenta:4.12 prostate:4.04 ovary:4.16 testis:3.91 heart:4.60 muscle:4.84 esophagus:4.27 stomach:4.23 intestine:4.49 colon:4.26 liver/hepato:4.42 lung:4.03 bladder:- kidney:4.44 pituitary:4.32 thyroid/parathyroid:4.10 adrenal gland:4.32 pancreas:4.35 breast:3.97 salivary:4.43
CAGE uterus:2.22 placenta:1.91 prostate:2.10 ovary:2.44 testis:1.37 heart:2.49 muscle:1.63 esophagus:2.12 stomach:- intestine:2.16 colon:2.48     liver/hepato:2.15    lung:1.64 bladder:1.95 kidney:2.06 pituitary:2.41 thyroid/parathyroid:2.25 adrenal gland:- pancreas:2.18 breast:2.27 salivary:2.69
RNA-seq uterus:- placenta:- prostate:2.05 ovary:2.15 testis:1.11 heart:2.28 muscle:2.67 esophagus:- stomach:- intestine:- colon:1.88     liver/hepato:1.61        lung:0.82    bladder:- kidney:1.62 pituitary:- thyroid/parathyroid:1.38 adrenal gland:0.82 pancreas:- breast:1.76 salivary:-

Gene Information

IDs

Refseq ID NM_018196
Gene ID 55217
Unigene ID Hs.133321
Probe set ID 218790_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000185973
GTEx ID ENSG00000185973

Orthologous Gene

Mouse[3]  NM_138758
Rat[1]  NM_133387

Chromosomal Region

Xq28  [154,719,776  -  154,899,605]

Gene Family (Interpro ID)

IPR003819  Taurine catabolism dioxygenase TauD/TfdA
IPR012776  Trimethyllysine dioxygenase

Link to Pubmed  (Pubmed ID)

8908511
11076863
11256614
11431483
12477932
14702039
15489334
15489336
15754339
15772651
16344560
16381901
17408883
21865298
21890473
22566635
23092983
24654937

Gene Ontology  (GO ID)

Biological Process

GO:0045329  carnitine biosynthetic process
GO:0034641  cellular nitrogen compound metabolic process
GO:0051354  negative regulation of oxidoreductase activity

Cellular Component

GO:0005759  mitochondrial matrix
GO:0005739  mitochondrion

Molecular Function

GO:0005506  iron ion binding
GO:0031418  L-ascorbic acid binding
GO:0016702  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0050353  trimethyllysine dioxygenase activity