palmitoyl-protein thioesterase 1

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Synonym

Palmitoyl-protein hydrolase 1, Palmitoyl-protein thioesterase 1 precursor, PPT-1, INCL, CLN1, PPT1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:29.60 cerebellum:327.40 brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:30.70 spine:112.30 retina:118.60 eye:5.90 artery/aorta:- vein:- lymphnode:- peripheral blood:- spleen:- thymus:- bone marrow:- adipose:- bone:- skin:4.80
GeneChip cerebrum:9.30 cerebellum:9.01 brain stem:9.52 corpus callosum/glia:9.11 pineal gland:- peripheral nerve:9.10 spine:9.46 retina:- eye:- artery/aorta:8.64 vein:8.65 lymphnode:8.69 peripheral blood:- spleen:9.04 thymus:8.75 bone marrow:8.88 adipose:8.49 bone:- skin:8.40
CAGE cerebrum:4.63 cerebellum:- brain stem:4.70 corpus callosum/glia:4.64 pineal gland:4.99 peripheral nerve:- spine:4.67 retina:- eye:- artery/aorta:4.50 vein:4.36 lymphnode:4.44 peripheral blood:- spleen:5.26 thymus:4.01 bone marrow:- adipose:4.70 bone:- skin:-
RNA-seq cerebrum:5.76 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:5.12 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.91 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:9.10 placenta:18.20 prostate:- ovary:- testis:- heart:12.80 muscle:- esophagus:- stomach:- intestine:- colon:-     liver/hepato:-        lung:9.80    bladder:- kidney:- pituitary:- thyroid/parathyroid:- adrenal gland:50.80 pancreas:- breast:- salivary:-
GeneChip uterus:9.01 placenta:8.49 prostate:9.67 ovary:8.80 testis:8.36 heart:8.08 muscle:7.27 esophagus:7.93 stomach:8.43 intestine:8.43 colon:8.29 liver/hepato:7.40 lung:9.52 bladder:- kidney:8.65 pituitary:8.80 thyroid/parathyroid:8.69 adrenal gland:8.57 pancreas:8.54 breast:9 salivary:8.71
CAGE uterus:4.08 placenta:4.22 prostate:4.27 ovary:4.26 testis:3.97 heart:3.91 muscle:3.20 esophagus:3.92 stomach:- intestine:3.63 colon:3.54     liver/hepato:3.78    lung:4.90 bladder:3.91 kidney:4.36 pituitary:4.15 thyroid/parathyroid:4.05 adrenal gland:- pancreas:4.01 breast:4.27 salivary:4.19
RNA-seq uterus:- placenta:- prostate:5.80 ovary:5.61 testis:5.02 heart:3.78 muscle:2.88 esophagus:- stomach:- intestine:- colon:5.03     liver/hepato:3.56        lung:5.67    bladder:- kidney:5.24 pituitary:- thyroid/parathyroid:5.44 adrenal gland:5.31 pancreas:- breast:4.91 salivary:-

Gene Information

IDs

Refseq ID NM_000310
Gene ID 5538
Unigene ID Hs.387300
Probe set ID 200975_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000131238
GTEx ID ENSG00000131238

Orthologous Gene

Mouse[2]  NM_008917
Rat[1]  NM_022502

Chromosomal Region

1p34.2  [40,538,379  -  40,563,375]

Gene Family (Interpro ID)

-

Link to Pubmed  (Pubmed ID)

7637805
7916016
8325646
8633062
8786130
8816748
8895569
9425237
9571187
9664077
10416973
10658183
10737604
10740217
10992246
11020216
11136716
11440996
11506414
11588997
11722572
12025857
12125808
12477932
12483688
12754519
12855696
15489334
15929065
16303743
16344560
16518810
16542649
16571600
17207965
17261688
17314511
18704195
19054571
19165527
19201763
19302939
19793631
19946888
20301334
20301601
21139048
21704547
21890473
21906983
21963094
21988832
22268729
22520356
22939629
24083319
24583282
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0008344  adult locomotory behavior
GO:0008306  associative learning
GO:0007420  brain development
GO:0044257  cellular protein catabolic process
GO:0051186  cofactor metabolic process
GO:0051181  cofactor transport
GO:0006309  DNA fragmentation involved in apoptosis
GO:0007625  grooming behavior
GO:0016042  lipid catabolic process
GO:0007042  lysosomal lumen acidification
GO:0031579  membrane raft organization
GO:0043066  negative regulation of apoptosis
GO:0030308  negative regulation of cell growth
GO:0043524  negative regulation of neuron apoptosis
GO:0007399  nervous system development
GO:0048666  neuron development
GO:0007269  neurotransmitter secretion
GO:0006907  pinocytosis
GO:0048549  positive regulation of pinocytosis
GO:0048260  positive regulation of receptor-mediated endocytosis
GO:0030163  protein catabolic process
GO:0002084  protein depalmitoylation
GO:0015031  protein transport
GO:0006898  receptor-mediated endocytosis
GO:0032429  regulation of phospholipase A2 activity
GO:0050803  regulation of synapse structure and activity
GO:0030149  sphingolipid catabolic process
GO:0007601  visual perception

Cellular Component

GO:0030424  axon
GO:0043025  cell soma
GO:0005829  cytosol
GO:0030425  dendrite
GO:0005576  extracellular region
GO:0005615  extracellular space
GO:0005794  Golgi apparatus
GO:0005764  lysosome
GO:0045121  membrane raft
GO:0005634  nucleus
GO:0008021  synaptic vesicle

Molecular Function

GO:0008474  palmitoyl-(protein) hydrolase activity
GO:0016290  palmitoyl-CoA hydrolase activity