protein kinase, AMP-activated, alpha 2 catalytic subunit

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Synonym

AMPK alpha-2 chain, PRKAA2, PRKAA, AMPK2

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:17.80

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:30.70

spine:-

retina:237.30

eye:94

artery/aorta:-

vein:-

lymphnode:-

peripheral blood:-

spleen:-

thymus:12.90

bone marrow:-

adipose:-

bone:-

skin:-

GeneChip

cerebrum:4.45

cerebellum:4.41

brain stem:4.47

corpus callosum/glia:4.38

pineal gland:-

peripheral nerve:4.73

spine:4.22

retina:-

eye:-

artery/aorta:4.36

vein:5.15

lymphnode:4.12

peripheral blood:-

spleen:4.14

thymus:3.97

bone marrow:4.28

adipose:4.15

bone:-

skin:4.15

CAGE

cerebrum:2.92

cerebellum:-

brain stem:2.36

corpus callosum/glia:2.18

pineal gland:3.38

peripheral nerve:-

spine:2.49

retina:-

eye:-

artery/aorta:2.72

vein:2.09

lymphnode:1.33

peripheral blood:-

spleen:1.85

thymus:0.91

bone marrow:-

adipose:2.61

bone:-

skin:-

RNA-seq

cerebrum:1.85

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:1.20

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.75

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:27.30

placenta:-

prostate:-

ovary:-

testis:4.30

heart:114.90

muscle:160.70

esophagus:-

stomach:-

intestine:-

colon:-

liver/hepato:10.60

lung:14.70

bladder:-

kidney:104

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:26.70

breast:-

salivary:-

GeneChip

uterus:4.24

placenta:4.18

prostate:4.29

ovary:4.35

testis:4.11

heart:5.93

muscle:6.15

esophagus:4.58

stomach:4.45

intestine:4.58

colon:4.45

liver/hepato:4.24

lung:4.21

bladder:-

kidney:5.32

pituitary:4.26

thyroid/parathyroid:4.51

adrenal gland:4.16

pancreas:4.75

breast:4.32

salivary:4.86

CAGE

uterus:2.56

placenta:0.85

prostate:2.74

ovary:2.57

testis:2.19

heart:4.38

muscle:4.95

esophagus:3.25

stomach:-

intestine:1.93

colon:2.57

liver/hepato:1.21

lung:1.95

bladder:3.00

kidney:3.70

pituitary:2.36

thyroid/parathyroid:2.41

adrenal gland:-

pancreas:2.34

breast:2.02

salivary:2.95

RNA-seq

uterus:-

placenta:-

prostate:2.28

ovary:1.51

testis:2.12

heart:5.40

muscle:5.53

esophagus:-

stomach:-

intestine:-

colon:2.50

liver/hepato:0.32

lung:1.17

bladder:-

kidney:3.21

pituitary:-

thyroid/parathyroid:2.85

adrenal gland:1.59

pancreas:-

breast:1.42

salivary:-

IDs

Refseq ID	NM_006252
Gene ID	5563
Unigene ID	Hs.437039
Probe set ID	207709_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000162409
GTEx ID	ENSG00000162409

Orthologous Gene

Mouse[1]	NM_178143
Rat [0]

Chromosomal Region

1p32.2 [57,110,995 - 57,181,008]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0006914	autophagy
GO:0006853	carnitine shuttle
GO:0007050	cell cycle arrest
GO:0044255	cellular lipid metabolic process
GO:0042149	cellular response to glucose starvation
GO:0031669	cellular response to nutrient levels
GO:0006695	cholesterol biosynthetic process
GO:0006112	energy reserve metabolic process
GO:0006633	fatty acid biosynthetic process
GO:0055089	fatty acid homeostasis
GO:0042593	glucose homeostasis
GO:0008286	insulin receptor signaling pathway
GO:0008610	lipid biosynthetic process
GO:0016044	membrane organization
GO:0043066	negative regulation of apoptosis
GO:0032007	negative regulation of TOR signaling pathway
GO:0010508	positive regulation of autophagy
GO:0045821	positive regulation of glycolysis
GO:0006468	protein amino acid phosphorylation
GO:0042752	regulation of circadian rhythm
GO:0042304	regulation of fatty acid biosynthetic process
GO:0006355	regulation of transcription, DNA-dependent
GO:0006950	response to stress
GO:0048511	rhythmic process
GO:0007165	signal transduction
GO:0006351	transcription, DNA-dependent
GO:0016055	Wnt receptor signaling pathway

Cellular Component

GO:0005829	cytosol
GO:0005654	nucleoplasm

Molecular Function

GO:0004679	AMP-activated protein kinase activity
GO:0005524	ATP binding
GO:0003682	chromatin binding
GO:0035174	histone serine kinase activity
GO:0046872	metal ion binding
GO:0005515	protein binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0050405	[acetyl-CoA carboxylase] kinase activity
GO:0047322	[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity

protein kinase, AMP-activated, alpha 2 catalytic subunit

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function