protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)

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Synonym

PRKAR1A, CNC1, PKR1, MGC17251, PRKAR1, Tissue-specific extinguisher 1, DKFZp779L0468, TSE1

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:683.80

cerebellum:2015

brain stem:-

corpus callosum/glia:204.10

pineal gland:148.30

peripheral nerve:460.10

spine:224.60

retina:-

eye:188.10

artery/aorta:359.70

vein:66.60

lymphnode:212.30

peripheral blood:327.90

spleen:132.30

thymus:682.80

bone marrow:137.80

adipose:121

bone:396.60

skin:235.20

GeneChip

cerebrum:9.30

cerebellum:9.38

brain stem:9.41

corpus callosum/glia:9.14

pineal gland:-

peripheral nerve:9.23

spine:9.56

retina:-

eye:-

artery/aorta:8.09

vein:8.74

lymphnode:8.19

peripheral blood:-

spleen:9.10

thymus:8.94

bone marrow:8.38

adipose:9.13

bone:-

skin:8.16

CAGE

cerebrum:5.46

cerebellum:-

brain stem:5.72

corpus callosum/glia:5.55

pineal gland:5.39

peripheral nerve:-

spine:5.34

retina:-

eye:-

artery/aorta:5.37

vein:5.10

lymphnode:4.85

peripheral blood:-

spleen:5.23

thymus:4.87

bone marrow:-

adipose:5.52

bone:-

skin:-

RNA-seq

cerebrum:0.00

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.00

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:0.54

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:656.20

placenta:262.30

prostate:112.60

ovary:74.50

testis:398

heart:306.50

muscle:80.40

esophagus:-

stomach:212.40

intestine:129.60

colon:118.70

liver/hepato:179.40

lung:1133.90

bladder:125.60

kidney:145.60

pituitary:463.90

thyroid/parathyroid:163.70

adrenal gland:101.60

pancreas:240.10

breast:306.70

salivary:328.40

GeneChip

uterus:9.39

placenta:8.57

prostate:9.32

ovary:9.69

testis:8.16

heart:9.65

muscle:8.60

esophagus:8.37

stomach:8.72

intestine:8.69

colon:8.11

liver/hepato:8.35

lung:8.89

bladder:-

kidney:8.98

pituitary:9.12

thyroid/parathyroid:9.03

adrenal gland:8.89

pancreas:8.01

breast:8.71

salivary:9.67

CAGE

uterus:5.33

placenta:5.03

prostate:5.09

ovary:5.57

testis:5.20

heart:5.71

muscle:5.51

esophagus:5.07

stomach:-

intestine:4.36

colon:4.59

liver/hepato:5.07

lung:5.30

bladder:5.21

kidney:5.16

pituitary:5.51

thyroid/parathyroid:5.17

adrenal gland:-

pancreas:4.58

breast:5.16

salivary:5.46

RNA-seq

uterus:-

placenta:-

prostate:0.17

ovary:0.00

testis:0.00

heart:0.00

muscle:0.00

esophagus:-

stomach:-

intestine:-

colon:0.43

liver/hepato:0.00

lung:0.00

bladder:-

kidney:0.00

pituitary:-

thyroid/parathyroid:0.00

adrenal gland:0.00

pancreas:-

breast:0.00

salivary:-

IDs

Refseq ID	NM_212472
Gene ID	5573
Unigene ID	Hs.280342
Probe set ID	200605_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000108946
GTEx ID	ENSG00000108946

Orthologous Gene

Mouse[2]	NM_021880
Rat[2]	NM_021880

Chromosomal Region

17q24.2 [66,508,110 - 66,528,908]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000595	Cyclic nucleotide-binding
IPR018490	Cyclic nucleotide-binding-like
IPR014710	RmlC-like jelly roll fold

Gene Ontology (GO ID)

Biological Process

GO:0007202	activation of phospholipase C activity
GO:0034199	activation of protein kinase A activity
GO:0007596	blood coagulation
GO:0060038	cardiac muscle cell proliferation
GO:0071377	cellular response to glucagon stimulus
GO:0006112	energy reserve metabolic process
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007143	female meiosis
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0045087	innate immune response
GO:0001707	mesoderm formation
GO:0045835	negative regulation of meiosis
GO:0048011	nerve growth factor receptor signaling pathway
GO:0050796	regulation of insulin secretion
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0045214	sarcomere organization
GO:0007165	signal transduction
GO:0055085	transmembrane transport
GO:0006833	water transport

Cellular Component

GO:0031588	AMP-activated protein kinase complex
GO:0005952	cAMP-dependent protein kinase complex
GO:0005829	cytosol
GO:0031594	neuromuscular junction
GO:0005886	plasma membrane
GO:0043234	protein complex

Molecular Function

GO:0030552	cAMP binding
GO:0004862	cAMP-dependent protein kinase inhibitor activity
GO:0008603	cAMP-dependent protein kinase regulator activity
GO:0005515	protein binding
GO:0034236	protein kinase A catalytic subunit binding
GO:0031625	ubiquitin protein ligase binding

protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function