DDB1 and CUL4 associated factor 6

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Synonym

ARCAP, MSTP055, 1200006M05Rik, IQ motif and WD repeats 1, NRIP, PC326, IQWD1

Expression Pattern

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:160 cerebellum:125.90 brain stem:- corpus callosum/glia:145.80 pineal gland:- peripheral nerve:30.70 spine:- retina:- eye:64.60 artery/aorta:269.80 vein:- lymphnode:60.70 peripheral blood:109.30 spleen:94.50 thymus:219 bone marrow:39.40 adipose:322.70 bone:179.10 skin:153.60
GeneChip cerebrum:6.37 cerebellum:6.50 brain stem:5.68 corpus callosum/glia:5.37 pineal gland:- peripheral nerve:6.97 spine:5.45 retina:- eye:- artery/aorta:6.49 vein:7.31 lymphnode:6.14 peripheral blood:- spleen:6.03 thymus:6.97 bone marrow:6.78 adipose:6.71 bone:- skin:6.76
CAGE cerebrum:4.04 cerebellum:- brain stem:3.60 corpus callosum/glia:3.43 pineal gland:3.63 peripheral nerve:- spine:3.51 retina:- eye:- artery/aorta:3.88 vein:3.91 lymphnode:3.64 peripheral blood:- spleen:3.72 thymus:3.80 bone marrow:- adipose:4.29 bone:- skin:-
RNA-seq cerebrum:1.59 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:1.54 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:1.86 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:91.10 placenta:76.50 prostate:169 ovary:37.30 testis:597 heart:153.30 muscle:221 esophagus:- stomach:42.50 intestine:97.20 colon:67.80     liver/hepato:73.90        lung:141.70    bladder:251.20 kidney:187.10 pituitary:116 thyroid/parathyroid:- adrenal gland:253.90 pancreas:44.50 breast:102.20 salivary:-
GeneChip uterus:7.01 placenta:6.20 prostate:7.46 ovary:7.17 testis:8.49 heart:7.81 muscle:9.81 esophagus:7.23 stomach:6.46 intestine:7.16 colon:6.03 liver/hepato:7.43 lung:6.49 bladder:- kidney:6.13 pituitary:6.15 thyroid/parathyroid:6.35 adrenal gland:7.05 pancreas:5.95 breast:6.79 salivary:6.30
CAGE uterus:4.20 placenta:3.58 prostate:4.06 ovary:3.84 testis:4.47 heart:5.02 muscle:6.01 esophagus:4.13 stomach:- intestine:3.94 colon:3.99     liver/hepato:4.78    lung:3.99 bladder:4.05 kidney:4.11 pituitary:4.16 thyroid/parathyroid:3.95 adrenal gland:- pancreas:3.34 breast:4.08 salivary:3.64
RNA-seq uterus:- placenta:- prostate:2.73 ovary:1.49 testis:4.33 heart:4.98 muscle:1.68 esophagus:- stomach:- intestine:- colon:2.54     liver/hepato:2.60        lung:1.00    bladder:- kidney:2.07 pituitary:- thyroid/parathyroid:2.73 adrenal gland:1.64 pancreas:- breast:2.01 salivary:-

Gene Information

IDs

Refseq ID NM_018442
Gene ID 55827
Unigene ID Hs.435741
Probe set ID 217908_s_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000143164
GTEx ID ENSG00000143164

Orthologous Gene

Mouse[1]  NM_028759
Rat[1]  NM_028759

Chromosomal Region

1q24.2  [167,905,021  -  168,045,081]

Gene Family (Interpro ID)

IPR001680  WD40 repeat
IPR011046  WD40 repeat-like-containing domain
IPR017986  WD40-repeat-containing domain
IPR015943  WD40/YVTN repeat-like-containing domain

Link to Pubmed  (Pubmed ID)

12477932
14702039
15761153
15784617
16169070
16341674
16344560
16949367
16964240
17984071
18673574
19064610
19295130
19536175
20360068
21139048
21145461
21282530
21890473
21906983
21963094
22037555
22053931
22177699
22863883
24222117
24250222

Gene Ontology  (GO ID)

Biological Process

GO:0045944  positive regulation of transcription from RNA polymerase II promoter
GO:0016567  protein ubiquitination

Cellular Component

GO:0080008  CUL4 RING ubiquitin ligase complex
GO:0005634  nucleus

Molecular Function

GO:0030374  ligand-dependent nuclear receptor transcription coactivator activity