mitogen-activated protein kinase 7

Synonym

MAPK7, ERK4, mitogen-activated protein kinase 7, ERK5, PRKM7, BMK1, BMK1 kinase, ERK-5, Extracellular signal-regulated kinase 5, Mitogen-activated protein kinase 7

normal 40 tissues
cell lines, primary cells, adult tissues and fetal tissues (FANTOM5 CAGE)

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain

blood

connective

EST

cerebrum:32

cerebellum:-

brain stem:-

corpus callosum/glia:87.50

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:58.80

artery/aorta:-

vein:-

lymphnode:10.10

peripheral blood:18.20

spleen:18.90

thymus:193.30

bone marrow:19.70

adipose:40.30

bone:51.20

skin:19.20

GeneChip

cerebrum:5.60

cerebellum:5.79

brain stem:5.52

corpus callosum/glia:5.69

pineal gland:-

peripheral nerve:5.96

spine:5.70

retina:-

eye:-

artery/aorta:6.12

vein:5.95

lymphnode:5.92

peripheral blood:-

spleen:5.89

thymus:5.44

bone marrow:5.88

adipose:6.15

bone:-

skin:6

CAGE

cerebrum:2.03

cerebellum:-

brain stem:2.23

corpus callosum/glia:2.40

pineal gland:2.60

peripheral nerve:-

spine:2.31

retina:-

eye:-

artery/aorta:3.06

vein:2.66

lymphnode:2.62

peripheral blood:-

spleen:2.88

thymus:1.81

bone marrow:-

adipose:2.79

bone:-

skin:-

RNA-seq

cerebrum:0.31

cerebellum:-

brain stem:-

corpus callosum/glia:-

pineal gland:-

peripheral nerve:-

spine:-

retina:-

eye:-

artery/aorta:-

vein:-

lymphnode:0.63

peripheral blood:-

spleen:-

thymus:-

bone marrow:-

adipose:2.08

bone:-

skin:-

reproductive

muscular

alimentary

liver

lung

urinary

endo/exo-crine

EST

uterus:82

placenta:10.90

prostate:11.30

ovary:74.50

testis:34.60

heart:-

muscle:-

esophagus:-

stomach:21.20

intestine:-

colon:-

liver/hepato:-

lung:19.60

bladder:-

kidney:20.80

pituitary:-

thyroid/parathyroid:-

adrenal gland:-

pancreas:-

breast:9.30

salivary:-

GeneChip

uterus:5.86

placenta:6.06

prostate:5.50

ovary:5.62

testis:6.44

heart:5.86

muscle:5.78

esophagus:6.20

stomach:5.83

intestine:6.06

colon:6.10

liver/hepato:5.79

lung:6.02

bladder:-

kidney:5.88

pituitary:6

thyroid/parathyroid:5.89

adrenal gland:6.12

pancreas:5.53

breast:5.93

salivary:5.64

CAGE

uterus:2.92

placenta:2.76

prostate:2.98

ovary:3.48

testis:3.00

heart:2.51

muscle:2.21

esophagus:3.02

stomach:-

intestine:2.71

colon:2.80

liver/hepato:1.90

lung:2.63

bladder:2.85

kidney:2.67

pituitary:2.37

thyroid/parathyroid:2.14

adrenal gland:-

pancreas:2.08

breast:2.79

salivary:2.06

RNA-seq

uterus:-

placenta:-

prostate:1.14

ovary:2.93

testis:2.13

heart:0.10

muscle:0.57

esophagus:-

stomach:-

intestine:-

colon:1.24

liver/hepato:0.11

lung:1.64

bladder:-

kidney:0.74

pituitary:-

thyroid/parathyroid:1.42

adrenal gland:1.34

pancreas:-

breast:1.00

salivary:-

IDs

Refseq ID	NM_002749
Gene ID	5598
Unigene ID	Hs.150136
Probe set ID	207292_s_at [HG-U133_Plus_2]
Ensembl ID	ENSG00000166484
GTEx ID	ENSG00000166484

Orthologous Gene

Mouse[1]	NM_011841
Rat [0]

Chromosomal Region

17p11.2 [19,281,034 - 19,286,857]

Search genes near this gene
- Between -5kb and +5kb
- Between -10kb and +10kb

Gene Family (Interpro ID)

IPR000719	Protein kinase, catalytic domain
IPR011009	Protein kinase-like domain
IPR002290	Serine/threonine-protein kinase domain
IPR017442	Serine/threonine-protein kinase-like domain
IPR001245	Tyrosine-protein kinase, catalytic domain
IPR020635	Tyrosine-protein kinase, subgroup, catalytic domain

Gene Ontology (GO ID)

Biological Process

GO:0006915	apoptosis
GO:0019933	cAMP-mediated signaling
GO:0007049	cell cycle
GO:0030154	cell differentiation
GO:0071363	cellular response to growth factor stimulus
GO:0070301	cellular response to hydrogen peroxide
GO:0071499	cellular response to laminar fluid shear stress
GO:0045087	innate immune response
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0030821	negative regulation of cAMP catabolic process
GO:0051344	negative regulation of cyclic-nucleotide phosphodiesterase activity
GO:0034115	negative regulation of heterotypic cell-cell adhesion
GO:0050728	negative regulation of inflammatory response
GO:0051534	negative regulation of NFAT protein import into nucleus
GO:0060761	negative regulation of response to cytokine stimulus
GO:0048011	nerve growth factor receptor signaling pathway
GO:0018105	peptidyl-serine phosphorylation
GO:0051247	positive regulation of protein metabolic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045765	regulation of angiogenesis
GO:0007165	signal transduction
GO:0051403	stress-activated MAPK cascade
GO:0034166	toll-like receptor 10 signaling pathway
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0002224	toll-like receptor signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005654	nucleoplasm
GO:0005634	nucleus
GO:0016605	PML body

Molecular Function

GO:0005524	ATP binding
GO:0004707	MAP kinase activity
GO:0051019	mitogen-activated protein kinase binding
GO:0005515	protein binding

mitogen-activated protein kinase 7

Synonym

Expression Pattern

Choropleth map on BodyParts3D

Classification in 40 Organs

Gene Information

IDs

Orthologous Gene

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed (Pubmed ID)

Gene Ontology (GO ID)

Biological Process

Cellular Component

Molecular Function