mitogen-activated protein kinase kinase 1

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Synonym

MAP kinase kinase 1, mitogen-activated protein kinase kinase 1, MAPK/ERK kinase 1, ERK activator kinase 1, MAPKK1, MEK1, PRKMK1, MAPKK 1, MKK1, MAP2K1

Choropleth map on BodyParts3D

Choropleth maps on 3D human body images were generated by the relative gene expression values measured by GeneChip.

Classification in 40 Organs

brain blood connective
EST cerebrum:39.10 cerebellum:12.60 brain stem:- corpus callosum/glia:58.30 pineal gland:148.30 peripheral nerve:61.30 spine:112.30 retina:- eye:35.30 artery/aorta:89.90 vein:66.60 lymphnode:151.70 peripheral blood:72.90 spleen:37.80 thymus:51.50 bone marrow:137.80 adipose:- bone:38.40 skin:72
GeneChip cerebrum:8.93 cerebellum:8.94 brain stem:8.25 corpus callosum/glia:7.72 pineal gland:- peripheral nerve:8.58 spine:8.40 retina:- eye:- artery/aorta:7.59 vein:8.20 lymphnode:8.19 peripheral blood:- spleen:8.02 thymus:7.96 bone marrow:8.23 adipose:8.49 bone:- skin:7.66
CAGE cerebrum:4.64 cerebellum:- brain stem:3.69 corpus callosum/glia:3.45 pineal gland:3.85 peripheral nerve:- spine:4.27 retina:- eye:- artery/aorta:4.24 vein:3.76 lymphnode:3.91 peripheral blood:- spleen:3.87 thymus:3.64 bone marrow:- adipose:4.18 bone:- skin:-
RNA-seq cerebrum:5.53 cerebellum:- brain stem:- corpus callosum/glia:- pineal gland:- peripheral nerve:- spine:- retina:- eye:- artery/aorta:- vein:- lymphnode:4.79 peripheral blood:- spleen:- thymus:- bone marrow:- adipose:4.16 bone:- skin:-
reproductive muscular alimentary liver lung urinary endo/exo-crine
EST uterus:109.40 placenta:10.90 prostate:67.60 ovary:- testis:26 heart:76.60 muscle:- esophagus:- stomach:42.50 intestine:32.40 colon:76.30     liver/hepato:52.80        lung:73.30    bladder:- kidney:31.20 pituitary:116 thyroid/parathyroid:- adrenal gland:101.60 pancreas:44.50 breast:55.80 salivary:-
GeneChip uterus:7.72 placenta:7.18 prostate:8.13 ovary:7.72 testis:7.19 heart:7.96 muscle:9 esophagus:8.73 stomach:7.73 intestine:7.96 colon:7.77 liver/hepato:8.53 lung:8.23 bladder:- kidney:8.02 pituitary:7.83 thyroid/parathyroid:7.67 adrenal gland:7.73 pancreas:7.46 breast:7.81 salivary:7.78
CAGE uterus:3.44 placenta:3.28 prostate:3.55 ovary:3.59 testis:2.96 heart:4.14 muscle:4.54 esophagus:3.77 stomach:- intestine:3.48 colon:3.65     liver/hepato:4.12    lung:4.10 bladder:3.88 kidney:3.72 pituitary:3.82 thyroid/parathyroid:3.44 adrenal gland:- pancreas:3.67 breast:4.46 salivary:3.27
RNA-seq uterus:- placenta:- prostate:4.31 ovary:4.02 testis:4.00 heart:3.89 muscle:4.11 esophagus:- stomach:- intestine:- colon:4.07     liver/hepato:4.03        lung:4.83    bladder:- kidney:4.41 pituitary:- thyroid/parathyroid:4.05 adrenal gland:4.03 pancreas:- breast:5.05 salivary:-

IDs

Refseq ID NM_002755
Gene ID 5604
Unigene ID Hs.145442
Probe set ID 202670_at  [HG-U133_Plus_2]
Ensembl ID ENSG00000169032
GTEx ID ENSG00000169032

Orthologous Gene

Mouse[1]  NM_008927
Rat [0]  

Chromosomal Region

Gene Family (Interpro ID)

Link to Pubmed  (Pubmed ID)

1281467
7601337
7624324
7731720
7957875
7969158
8131746
8157000
8226933
8388392
8394352
8529659
8621729
8626767
8631303
8900182
8939914
9006895
9069267
9223324
9311917
9325171
9351825
9465908
9553107
9558095
9563949
9564043
9621077
9733512
9765203
9841871
10395327
10402467
10409742
10489373
10509564
10523642
10570282
10712923
10716983
10748187
10757792
10780709
10799874
10806207
10828601
10848576
10912793
10958680
10969079
10982368
10997882
11044099
11044439
11104681
11134045
11226259
11260070
11266467
11278389
11279118
11352917
11409852
11520933
11535599
11579140
11604401
11684694
11726657
11741534
11741894
11823456
11891225
11940661
11948406
12032872
12063167
12089333
12167619
12370306
12456688
12477932
12482669
12522135
12522145
12531514
12556561
12594221
12609978
12612059
12663662
12682854
12689928
12697810
12775419
12788955
12792650
12807433
12839928
12917419
12975377
14500727
14581471
14656894
14672918
14724641
15020233
15021912
15069060
15090600
15118098
15155804
15231747
15258589
15276183
15284233
15292274
15297310
15299019
15302887
15353548
15485920
15520859
15538402
15543157
15557124
15572374
15615716
15638726
15657353
15657590
15665520
15757891
15866172
15888452
15979847
16086581
16093354
16239230
16291755
16313339
16344560
16439621
16454711
16533805
16728640
16737746
16810323
16820947
16861903
16888650
16957420
17038630
17054908
17101779
17182854
17192257
17197157
17260965
17366577
17419998
17461449
17490600
17603482
17623298
17667937
17704260
17951252
17979178
17981815
18029348
18042262
18060073
18192500
18329369
18332145
18390968
18413255
18424438
18434598
18533112
18556463
18569454
18593598
18617556
18632602
18660489
19001375
19014680
19056740
19133693
19153083
19156172
19164283
19206169
19261809
19322201
19342664
19411838
19447520
19453261
19500021
19565474
19567590
19625741
19681119
19802003
19816936
19835659
19858308
19953087
20007706
20019835
20056645
20172001
20179161
20212043
20299489
20301303
20301365
20302979
20354455
20404718
20433920
20512084
20610816
20676060
20885957
20926789
20936779
20956560
21131601
21139048
21179471
21336309
21383288
21447798
21458501
21567396
21621846
21675959
21705440
21707777
21713404
21835307
21890473
21906983
21965271
22037177
22052387
22053931
22180573
22188669
22197931
22241220
22298595
22327936
22357202
22495818
22546605
22588879
22707717
22752157
22773810
22791812
22805291
22805292
22833572
22902540
22935974
22946047
22946697
23000965
23001481
23157514
23225884
23237773
23241949
23360980
23383273
23423222
23524336
23555914
23684925
23698055
23727904
23746211
23852369
23923067
24011934
24091658
24211253
24241536
24255178
24501087
24639526
24704364
24816145

Gene Ontology  (GO ID)

Biological Process

GO:0000187  activation of MAPK activity
GO:0000186  activation of MAPKK activity
GO:0007411  axon guidance
GO:0007050  cell cycle arrest
GO:0048870  cell motility
GO:0008283  cell proliferation
GO:0006928  cellular component movement
GO:0006935  chemotaxis
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0008543  fibroblast growth factor receptor signaling pathway
GO:0048313  Golgi inheritance
GO:0045087  innate immune response
GO:0008286  insulin receptor signaling pathway
GO:0030216  keratinocyte differentiation
GO:0060711  labyrinthine layer development
GO:0000165  MAPKKK cascade
GO:0032402  melanosome transport
GO:0007067  mitosis
GO:0002755  MyD88-dependent toll-like receptor signaling pathway
GO:0002756  MyD88-independent toll-like receptor signaling pathway
GO:0008285  negative regulation of cell proliferation
GO:0034111  negative regulation of homotypic cell-cell adhesion
GO:0048011  nerve growth factor receptor signaling pathway
GO:0060674  placenta blood vessel development
GO:0045597  positive regulation of cell differentiation
GO:0030335  positive regulation of cell migration
GO:0032320  positive regulation of Ras GTPase activity
GO:0046579  positive regulation of Ras protein signal transduction
GO:0032968  positive regulation of RNA elongation from RNA polymerase II promoter
GO:0051291  protein heterooligomerization
GO:0007265  Ras protein signal transduction
GO:0090170  regulation of Golgi inheritance
GO:0032872  regulation of stress-activated MAPK cascade
GO:0003056  regulation of vascular smooth muscle contraction
GO:0048678  response to axon injury
GO:0051384  response to glucocorticoid stimulus
GO:0006979  response to oxidative stress
GO:0007165  signal transduction
GO:0007264  small GTPase mediated signal transduction
GO:0051403  stress-activated MAPK cascade
GO:0034166  toll-like receptor 10 signaling pathway
GO:0034134  toll-like receptor 2 signaling pathway
GO:0034138  toll-like receptor 3 signaling pathway
GO:0034142  toll-like receptor 4 signaling pathway
GO:0034146  toll-like receptor 5 signaling pathway
GO:0034162  toll-like receptor 9 signaling pathway
GO:0002224  toll-like receptor signaling pathway
GO:0047496  vesicle transport along microtubule

Cellular Component

GO:0005938  cell cortex
GO:0005737  cytoplasm
GO:0005829  cytosol
GO:0032839  dendrite cytoplasm
GO:0005769  early endosome
GO:0005925  focal adhesion
GO:0005794  Golgi apparatus
GO:0005770  late endosome
GO:0005739  mitochondrion
GO:0005634  nucleus
GO:0043204  perikaryon
GO:0048471  perinuclear region of cytoplasm
GO:0005886  plasma membrane
GO:0005816  spindle pole body

Molecular Function

GO:0005524  ATP binding
GO:0004708  MAP kinase kinase activity
GO:0031435  mitogen-activated protein kinase kinase kinase binding
GO:0005515  protein binding
GO:0004672  protein kinase activity
GO:0043539  protein serine/threonine kinase activator activity
GO:0004674  protein serine/threonine kinase activity
GO:0004712  protein serine/threonine/tyrosine kinase activity
GO:0004713  protein tyrosine kinase activity
GO:0017016  Ras GTPase binding
GO:0004728  receptor signaling protein tyrosine phosphatase activity